DailyUpdates for Breaking Research
DailyUpdates features breaking research judged by LeadDiscovery's editorial team to be of key importance to drug development. Papers are selected from over 10,000 published each week from most pear reviewed journals.
A list of headline articles featured over the past week are listed below.
To submit you paper to be listed on DailyUpdates contact LeadDiscovery.
Research featured over the past 5 days
- The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.
- Efficacy and safety of colesevelam in patients with type 2 diabetes mellitus and inadequate glycemic control receiving insulin-based therapy.
- Novel Role for RGS1 in Melanoma Progression.
- Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis.
- Long-term Treatment With Ranirestat (AS-3201), a Potent Aldose Reductase Inhibitor, Suppresses Diabetic Neuropathy and Cataract Formation in Rats.
- Recent advances in the preclinical evaluation of the topical antibacterial agent REP8839.
- Daclizumab in combination with Mycophenolate Mofetil and a late introduction of Tacrolimus at low doses, as a therapeutic approach in the elderly renal transplant donor-recipients.
- Prostaglandin E(2)-loaded microspheres as strategy to inhibit phagocytosis and modulate inflammatory mediators release.
- Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.
- Optimization and validation of a reporter gene assay for screening of phosphodiesterase inhibitors in a high throughput system.
- Neurotoxic effect of oligomeric and fibrillar species of amyloid-beta peptide 1-42 peptide: Involvement of endoplasmic reticulum calcium release in oligomer-induced cell death.
- The Efficacy of Quinoxaline-2-carboxylate 1,4-di-N-oxide Derivatives in Experimental Tuberculosis.
- Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: Optimizing the fit to the active site.
- DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles.
- Epitope characterization of the protective monoclonal antibody VN04-2 shows broadly neutralizing activity against highly pathogenic H5N1.
- A Phase I Study of Bolus 5-fluorouracil and Leucovorin Combined with Weekly Paclitaxel (FLTAX) as First-line Therapy for Advanced Gastric Cancer.
- Single-Day, Patient-Initiated Famciclovir Therapy versus Three-Day Valacyclovir Regimen for Recurrent Genital Herpes: A Randomized, Double-Blind, Comparative Trial.
- Oral immunization with recombinant Lactobacillus plantarum induces a protective immune response in the Lyme disease mouse model.
- Cyclocondensation reaction of heterocyclic carbonyl compounds, Part XIII: Synthesis and cytotoxic activity of some 3,7-diaryl-5-(3,4,5-trimethoxyphenyl)pyrazolo[4,3-e][1,2,4]triazines.
- Kinetic Studies of Cdk5/p25 Kinase: Phosphorylation of Tau and Complex Inhibition by Two Prototype Inhibitors.