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Stem Cell Markets

The purpose of this report is to analyse the landscape and market around therapeutic stem cells. 

A stem cell is an extraordinary type of cell that has the ability to self-renew for long periods of time and to differentiate into specialized cells under appropriate physiological or experimental conditions. Traditionally, stem cells have been classified as either embryonic or adult (tissue-specific or cord blood) stem cells. Recent understanding of stem cell biology may provide new approaches for the treatment of a number of diseases as well as tissue/organ injuries, including cardiovascular disease, neurological disease, musculoskeletal disease, diabetes and hematopoietic disorders.

Stem cell fate is determined by both intrinsic regulators and the extra-cellular environment (niche), and their expansion and differentiation ex vivo are generally controlled by growing them in a specific configuration (monolayer or three-dimensional culture). Differentiation is a process involving unspecialized cells progressing to become specialized cells with restricted developmental potential.

This report reviews all of the generally accepted analytical methods that are currently in use today for preparing and using stem cells. It also examines the use of stem cells in developing new therapies for disease.

Table of Contents

• 1.Overview3
  • 1.1Statement of Report3
  • 1.2Scope of the Report4
  • 1.3Methodology4
  • 1.4Executive Summary5
  
  
• 2.Biology of Stem Cells7
  • 2.1Scope of this Chapter7
  • 2.2Basic Properties of Stem Cells and Their Classification7
  • 2.3Differentiation of Stem Cells10
    • 2.3.1Neural and Neuronal Differentiation10
    • 2.3.2Cardiomyogenic Differentiation of ESCs10
    • 2.3.3Differentiation of Mesenchymal Stem/Progenitor Cells11
  • 2.4Self Renewal of Stem Cells11
  • 2.5Dedifferentiation and Nuclear Reprogramming12
  • 2.6Functional Proliferation of Adult Mature Cells13
  • 2.7Nanog Promotes Transfer of Pluripotency After Cell Fusion13
  • 2.8MicroRNAs in Stem Cell Development14
  • 2.9Stem Cell Therapy14
  
  
• 3.Market Analysis of the Stem Cell Space15
  • 3.1Scope of this Chapter15
  • 3.2The Overall Market Opportunity and Segmentation of the Total Stem Cell Marketplace15
  • 3.3Potential Stem Cell Commercial Applications18
    • 3.3.1Cord Blood Stem Cells and Cord Blood Stem Cell Banking: Current Market Environment and Opportunity18
  • 3.4Results of Primary Market Survey to Characterize Qualitative and Quantitative Trends in the Stem Cells Space21
    • 3.4.1Characteristics of the Respondent Pool22
    • 3.4.2Utilization of the Different Classes of Stem Cells24
    • 3.4.3Quantitative Metrics of the Stem Cell Research Marketplace: Number of Experiments Performed in Research25
    • 3.4.4Evolution of Research Activities with the Different Types of Stem Cells: Current Usage Trends and Usage in 12 to 18 Months29
    • 3.4.5Types of Research Activities the End-User Community Performs with the Different Types of Stem Cells31
    • 3.4.6Challenges Facing Stem Cell Researchers34
    • 3.4.7Market Drivers and Research Questions Being Addressed in the Stem Cell Space38
    • 3.4.8Summary of Challenges and Opportunities in the Stem Cell Space Based on TriMark\'s Analysis39
    • 3.4.9Unmet Product Needs in the Stem Cell Research Space and Licensing/IP Constraints40
  • 3.5Competitive Landscape of the Stem Cell Marketplace42
    • 3.5.1SWOT Analysis of the Major Stem Cell Market Segments49
  • 3.6Market Size and Forecasts52
  
  
• 4.Worldwide Landscape of Stem Cell Research56
  • 4.1Scope of this Chapter56
  • 4.2Global Embryonic Stem Cell Research56
    • 4.2.1Top Research Institutions Worldwide in the Stem Cells Space and Global "Hot Spots" for Research and Therapeutics57
  • 4.3Stem Cell Research in the U.S.59
    • 4.3.1Proposition 71 in the State of California61
  • 4.4Intellectual Property (IP) Landscape Surrounding Stem Cells62
  • 4.5Who Will Finance Stem Cell Research?64
    • 4.5.1U.S. Government Policy on Stem Cell Research64
    • 4.5.2Current Federal Policy67
      • 4.5.2.1Moral Issues Affecting the Policy68
      • 4.5.2.2Significance and Requirement of Federal Funding70
      • 4.5.2.3Implementing the Current Policy72
    • 4.5.3International Law74
      • 4.5.3.1Australia74
      • 4.5.3.2U.K.74
      • 4.5.3.3Canada74
      • 4.5.3.4China75
      • 4.5.3.5Germany76
      • 4.5.3.6Switzerland76
      • 4.5.3.7Japan76
      • 4.5.3.8Israel76
      • 4.5.3.9Singapore77
    • 4.5.4Technological and Economical Disadvantage for U.S.77
    
    
• 5.Therapeutic Areas and Research Programs in the Stem Cell Space79
  • 5.1Scope of this Chapter79
  • 5.2Therapeutic and Other Markets Addressed by Stem Cells79
    • 5.2.1Hematopoietic Stem Cells (HSCs)80
    • 5.2.2Stem Cell Therapeutics for Cardiac and Ischemic Diseases83
    • 5.2.3Stem Cell Therapeutics for Type I Diabetes85
    • 5.2.4Stem Cell Therapeutics for Orthopedic Diseases86
    • 5.2.5Stem Cell Therapeutics for Neurological Disease86
  • 5.3Off-the-Shelf Stem Cells Being Developed87
• 6.Company Profiles90

 

Appendix 1.Glossary of Terms in Stem Cell Biology104

INDEX OF FIGURES

Figure 2.1: Derivation of Embryonic Stem Cells (ESCs) from the Inner Cell Mass of Blastocysts8

Figure 2.2: Classification of Stem Cells: Embryonic Stem Cells Versus Adult Stem Cells9

Figure 2.3: Somatic Cell Nuclear Transfer (SCNT)12

Figure 3.1: Segmentation of the Stem Cell Marketplace Based Upon Commercial Offerings-Products and Services17

Figure 3.2: Geographical Breakout of Stem Cell End-User Survey Respondents22

Figure 3.3: Affiliation (Pharma, Biotech, Academic/University) of Stem Cell End-User Survey Respondents22

Figure 3.4: Survey Respondents Are Studying Stem Cells or Using Stem Cells in Their Research23

Figure 3.5: Length of Time Survey Respondent Pool Has Been Studying Stem Cells or Using Stem Cells in Its Research Activities23

Figure 3.6: Utilization/Research with Different Stem Cell Types24

Figure 3.7: Range of Number of Experiments Involving Stem Cells Conducted Per Week25

Figure 3.8: Differences with Respect to Usage of Stem Cell Types26

Figure 3.9: Research Dollars Spent Monthly on Research/Studies with Different Stem Cell Types27

Figure 3.10: Growth of Research Spending in Various Segments of the Stem Cells Space (Defined by Stem Cell Type)28

Figure 3.11: Growth in End-User Utilization of the Various Different Stem Cell Types28

Figure 3.12: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells30

Figure 3.13: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months30

Figure 3.14: Broad Classification of Research Activities Being Performed with Stem Cells by Researchers31

Figure 3.15: Current End-User Utilization Category of Adult Stem Cells (ASCs)32

Figure 3.16: Current End-User Utilization Category of Human Embryonic Stem Cells (hESCs)32

Figure 3.17: Current End-User Utilization Category of Human Cord Blood Stem Cells32

Figure 3.18: Current End-User Utilization Category of Animal Stem Cells33

Figure 3.19: Current End-User Utilization Category of Cancer Stem Cells33

Figure 3.20: Challenges in the Study or Utilization of Adult Stem Cells (ASCs)35

Figure 3.21: Challenges in the Study or Utilization of Human Embryonic Stem Cells (hESCs)35

Figure 3.22: Challenges in the Study or Utilization of Human Cord Blood Stem Cells36

Figure 3.23: Challenges in the Study or Utilization of Animal Stem Cells36

Figure 3.24: Challenges in the Study or Utilization of Cancer Stem Cells37

Figure 3.25: Top Unmet Needs in Commercial Products in the Stem Cell Research Space41

Figure 3.26: The U.S. Stem Cell Therapy Market Sales, 2005-201654

Figure 4.1: Stem Cell Research Worldwide58

INDEX OF TABLES

Table 2.1: The Different Types of Stem Cells and Their Properties9

Table 2.2: Adult Stem Cell (ASC) Differentiation Properties10

Table 3.1: Characteristics of Different Stem Cell Types and Associated Market Opportunity16

Table 3.2: Segmentation of the Stem Cell Market by Type/Lineage of Stem Cells17

Table 3.3: Selected Cord Blood Banks in the U.S.20

Table 3.4: Selected Companies in the Cord Blood Stem Cell Technology and Therapeutics Development Space21

Table 3.5: Breakout of the Stem Cell Research Market: Current Research Efforts with Different Types of Stem Cells29

Table 3.6: Breakout of the Stem Cell Research Market: Research Efforts with Different Types of Stem Cells in 12 to 18 Months29

Table 3.7: Market Share of Companies/Institutions Offering Different Stem Cells to Researchers44

Table 3.8: Market Share of Companies/Institutions Offering Reagents for Stem Cell Research45

Table 3.9: The U.S. Stem Cell Therapy Market Forecast, 2005-201653

Table 3.10: The World Market for Stem Cell Products and Services, 2005-201255

Table 4.1: Major Milestones in Stem Cell Research and Associated Timeline, 1981-200857

Table 4.2: Selected Stem Cell Hot Spots Worldwide Administering Non-FDA Approved Stem Cell Therapeutic Regimens59

Table 4.3: NIH Funding of Stem Cell Research in the U.S., 2004-200960

Table 4.4: Snapshot of the Current Key Stem Cell Patents63

Table 4.5: Stem Cell Derivations72

Table 5.1: Estimate of Potential Market Opportunity for Stem Cell-based Therapeutics79

Table 5.2: Autologous Versus Allogeneic Cell Therapy80

Table 5.3: Diseases Treated with HSC Transplantation Today81

Table 5.4: HSC Sources and Their Properties82

Table 5.5: Stem Cell Therapeutics for Hematological Diseases in Development83

Table 5.6: Stem Cell-based Therapeutics for Cardiac and Ischemic Diseases in Development84

Table 5.7: Stem Cell-based Therapeutics for Vascular Diseases in Development85

Table 5.8: Stem Cell Therapeutics for Type I Diabetes in Development85

Table 5.9: Stem Cell Therapeutics for Orthopedic Disease in Development86

Table 5.10: Stem Cell Therapeutics for Neurological Disease in Development87

Table 5.11: Segmentation of the Allogeneic Cell Therapy Market89

 

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