Antibacterials - Growth in resistance rates drives niche indications
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Respiratory and Infectious Diseases pharmaceutical analysis team - page 2
- CHAPTER 1: EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the antibacterials market - page 3
- CHAPTER 2: MARKET DEFINITION AND OVERVIEW - page 14
- Market definition for this report - page 14
- ATC classes covered - page 14
- Classification of pathogens and sites of infection - page 16
- Gram staining - page 16
- Bacterial growth conditions - page 17
- Site of infection - page 17
- Hospital and community market - page 18
- Current market situation - page 19
- Although highly mature, the antibacterial market is still growing - page 19
- Four classes dominate the antibacterial market - page 20
- Penicillins - page 20
- Cephalosporins - page 21
- Fluoroquinolones - page 23
- Macrolides and ketolides - page 23
- The antibacterial market is highly segmented - page 24
- Several blockbusters share the market lead - page 25
- Cephalosporins are ahead in terms of sales - page 27
- Penicillins remain the most widely used class - page 29
- Most large pharma companies are active in the antibacterial market - page 31
- The antibacterial market is highly genericized - page 32
- Although the community market is still dominant, the hospital market is gaining in importance - page 35
- The US continues to be the biggest market for antibacterials - page 38
- Key unmet needs lie in the treatment of infections caused by MRSA and gram-negative pathogens - page 39
- Strategic scoping and focus - page 41
- Market definition for this report - page 14
- CHAPTER 3: COUNTRY MARKET ASSESSMENTS - page 42
- Global opportunities and threats - page 42
- Opportunities - page 42
- Increasing age of the population and higher likelihood of bacterial infections among the elderly will expand the antibacterial market - page 42
- The increasing number of immunocompromised patients constitutes a large future patient pool - page 45
- New market opportunities arise because of increasing resistances against available drugs - page 46
- Acceleration and harmonization of approval procedures - page 48
- Threats - page 49
- Patent expiry and cost containment drive generic incursion - page 49
- Governments impose pricing pressure on drug manufacturers as a consequence of cost containment needs - page 52
- Parallel trade - illegal in the US, encouraged in Europe - page 53
- New vaccination strategies reduce the need for antibacterial treatment - page 55
- Increasing drug resistance promotes new treatment guidelines and restrics antibacterial use - page 56
- Opportunities - page 42
- US: opportunities and threats - page 58
- Antibacterial market overview - page 58
- Opportunities - page 62
- Direct-to-consumer advertising - page 62
- Branded products achieve high prices as a result of the free pricing system - page 63
- Threats - page 63
- Initiatives by public and private health providers aim to encourage cost containment - page 63
- Further genericization is encouraged by legislation and public programs - page 64
- Although still illegal, parallel trade is likely to be legalized in the medium term - page 67
- Japan: opportunities and threats - page 67
- Antibacterial market overview - page 67
- Opportunities - page 70
- Acceleration of the drug approval process maximizes profit opportunities - page 70
- Separation of manufacturing and marketing entities will benefit both local companies and foreign investors - page 71
- Enhanced R&D activity as a result of new legislation allowing outsourcing - page 71
- Threats - page 72
- Genericization is slowly taking off - page 72
- More restrictive cost containment measurements are under discussion - page 73
- France: opportunities and threats - page 73
- Antibacterial market overview - page 73
- Opportunities - page 76
- Critical attitude towards MRP slows down generic penetration - page 76
- High prescription volume boosts drug revenues - page 77
- The creation of HAS facilitates P&R approval - page 77
- Reimbursement system favors use of innovative drugs - page 78
- Threats - page 79
- Cost containment policies aim at reducing the expenditure for prescription drugs - page 79
- Genericization has increased recently and is further supported - page 80
- Germany: opportunities and threats - page 82
- Antibacterial market overview - page 82
- Opportunities - page 85
- Legalization of mail order provides new distribution channels - page 85
- Free pricing system and culture of innovation encourages novel drug development - page 85
- Fewer cost containment restrictions make the hospital sector a valuable opportunity - page 86
- Threats - page 86
- Jumbo Reference Pricing is threatening drug revenue growth - page 86
- Increasing genericization is strongly supported by the government - page 87
- Italy: opportunities and threats - page 89
- Antibacterial market overview - page 89
- Opportunities - page 91
- The ageing population and the increasing incidence of severe infections fuel a growth in the hospital market - page 91
- Low levels of generic penetration as a result of lack of confidence - page 92
- Reimbursement levels are determined by negotiations rather than regulations - page 92
- Threats - page 93
- Unpredictability of regulations hampers reliable strategic planning - page 93
- Reference pricing might result in downward price spirals and support genericization - page 94
- Spain: opportunities and threats - page 96
- Antibacterial market overview - page 96
- Opportunities - page 97
- Legislation and reimbursement schemes support innovation - page 97
- Decentralization of the healthcare system provides localized opportunities - page 98
- Threats - page 99
- Cost containment measurements restrict manufacturer's profit margins - page 99
- Government encourages generic use - page 100
- UK: opportunities and threats - page 100
- Antibacterial market overview - page 100
- Opportunities - page 102
- Decreasing incentives for pharmacists to prescribe generics as a result of new DoH initiative - page 102
- Promising niche markets as a result of MRSA and other superbugs - page 103
- OTC is a possible long-term opportunity - page 104
- Threats - page 105
- Price reduction for branded products after PPRS change in 2004 - page 105
- Complex structures for P&R negotiations elongate time to market - page 106
- High generic penetration is a large challenge for brand manufacturers - page 107
- Summary of environmental issues affecting the antibacterial country markets - page 108
- Global opportunities and threats - page 42
- CHAPTER 4: FORECAST ANALYSIS - page 110
- Assumptions and events - page 110
- Events excluded from the forecast - page 110
- Product- and class-specific events - page 110
- Patent expiries and genericization - page 110
- Additional indications and major clinical trials - page 111
- Cephalosporins - page 111
- Fluoroquinolones - page 114
- Macrolides - page 118
- Penicillins - page 120
- Carbapenems - page 121
- Aminoglycosides - page 122
- All others - page 123
- New product launches - page 126
- Regional launch date for new products - page 127
- Data definitions, limitations and assumptions - page 127
- Standard units - page 127
- Japanese market data - page 127
- Derivation of sales forecasts and pricing trends - page 128
- Forecasts - page 128
- Forecast methodology - page 128
- Assumptions and events - page 110
- CHAPTER 5: COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 129
- Avoiding the crash - lifecycle management strategies of big pharma facing blockbuster patent expiries - page 129
- Pfizer, Abbott, Roche: Key 2005 lifecycle management strategies in the US antibacterial market - page 130
- Pfizer: bouncing back from Zmax failure with generic azithromycin - page 131
- Abbott: successful switch to Biaxin XL - page 136
- Roche - exiting the antibacterial market after Rocephin's fall - page 140
- Line extensions - top or flop? - page 143
- Statistical data are overall supportive of line extensions - page 144
- Examples show that careful planning of line extensions is neccessary - page 144
- Pfizer, Abbott, Roche: Key 2005 lifecycle management strategies in the US antibacterial market - page 130
- Avoiding the crash - lifecycle management strategies of big pharma facing blockbuster patent expiries - page 129
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 146
- Summary antibacterials market data - page 146
- CEPHALOSPORINS (J1D1, J1D2) market data - page 149
- FLUOROQUINOLONES (J1G1, J1G2) market data - page 164
- MACROLIDES (J1F0) market data - page 169
- PENICILLINS (J1C1, J1C2, J1H1) market data - page 173
- CARBAPENEMS (J1P2) market data - page 176
- GLYCOPEPTIDES (J1X1) market data - page 179
- AMINOGLYCOSIDES (J1K0) market data - page 181
- TETRACYCLINES (J1A0) market data - page 182
- All others (J1X) market data - page 184
- APPENDIX B - BIBLIOGRAPHY - page 188
- Journal articles - page 188
- Publications by governmental or regulatory authorities - page 189
- Company Press Releases - page 193
- News articles - page 195
- Analyst reports - page 197
- Report methodology - page 197
- About Datamonitor - page 198
- About Datamonitor Healthcare - page 198
- About the Antibacterials analysis team - page 199
- Key therapy team members - page 199
- Holger Rovini, Head of Respiratory and Infectious Diseases - page 199
- Hedwig Kresse, Associate Analyst, Infectious Diseases - page 200
- Disclaimer - page 201
- List of Tables
- Table 1: Definition of combined antibacterial classes used throughout the report - page 15
- Table 2: Key players in the antibacterial market - page 26
- Table 3: Global antibacterial sales by class, 2001-2005 - page 29
- Table 4: CAGRs across the US, EU5 and Pacific Rim, 2001-2005 - page 39
- Table 5: Loss of sales of blockbuster antibacterials in the first year after patent expiry - page 50
- Table 6: Antibacterial vaccines in advanced clinical development, 2006 - page 56
- Table 7: Antibacterial sales in the US by class, 2001-2005 - page 59
- Table 8: Antibacterial sales in Japan by class, 2001-2005 - page 68
- Table 9: Leading brands in the Japanese market developed by Japanese companies - page 69
- Table 10: Antibacterial sales in France by class, 2001-2005 - page 74
- Table 11: Antibacterial sales in Germany by class, 2001-2005 - page 83
- Table 12: Antibacterial market in Italy by class, 2001-2005 - page 90
- Table 13: Antibacterial market in Spain by class, 2001- 2005 - page 96
- Table 14: Antibacterial market in the UK by class, 2001-2005 - page 101
- Table 15: Developmental antibacterials in Phase III - page 126
- Table 16: Impact of generic incursion in the US following loss of patent protection on brand sales for brands with and without follow-up products - page 144
- Table 17: Definition of the Pacific Rim in terms of countries and channels included - page 146
- Table 18: Summary market data US - page 146
- Table 19: Summary market data key countries Pacific Rim - page 147
- Table 20: Summary market data EU5 - page 148
- Table 21: Rocephin: key facts - page 149
- Table 22: Omnicef: key facts - page 151
- Table 23: Flomox: key facts - page 152
- Table 24: Fortaz: key facts - page 153
- Table 25: Maxipime: key facts - page 154
- Table 26: Vantin/Orelox: key facts - page 155
- Table 27: Cefzil: key facts - page 156
- Table 28: Meiact/Spectracef: key facts - page 157
- Table 29: Flumarin: key facts - page 158
- Table 30: Suprax: key facts - page 159
- Table 31: Ceftin/Zinnat: key facts - page 160
- Table 32: Sulperazon: key facts - page 161
- Table 33: Pansporin: key factss - page 162
- Table 34: Ceclor: key facts - page 163
- Table 35: Levaquin: key facts - page 164
- Table 36: Cipro: key facts - page 165
- Table 37: Avelox: key facts - page 166
- Table 38: Tequin: key facts key facts - page 167
- Table 39: Floxin: key facts - page 168
- Table 40: Zithromax: key facts - page 169
- Table 41: Biaxin: key facts - page 170
- Table 42: Ketek: key facts - page 171
- Table 43: Cleocin: key facts - page 172
- Table 44: Zosyn: key facts - page 173
- Table 45: Augmentin: key facts - page 174
- Table 46: Unasyn: key facts - page 175
- Table 47: Primaxin: key facts - page 176
- Table 48: Merrem: key facts - page 177
- Table 49: Invanz: key facts - page 178
- Table 50: Vancomycin: key facts - page 179
- Table 51: Targocid: key facts - page 180
- Table 52: Tobi: key facts - page 181
- Table 53: Doxycycline hyclate (molecule): key facts - page 182
- Table 54: Zyvox: key facts - page 184
- Table 55: Cubicin: key facts - page 185
- Table 56: Pyostacine: key facts - page 187
- List of Figures
- Figure 1: Antibacterial sales across the seven major markets by sales and volume, 2001-2005 - page 19
- Figure 2: Market shares (sales) of the leading antibacterial drug classes - page 20
- Figure 3: Global antibacterial sales by class, 2001-2005 - page 28
- Figure 4: Global antibacterial volume use by class, 2001-2005 - page 30
- Figure 5: Generic incursion in penicillin subclasses, 2005 - page 31
- Figure 6: Leading companies in the antibacterial market, 2005 - page 32
- Figure 7: Generic sales and volume use in antibacterials by geographic area, 2005 - page 33
- Figure 8: Global generic sales and volume use by class, 2005 - page 34
- Figure 9: Sales and volume use in the hospital vs the community market, excluding Japan, 2001-2005 - page 35
- Figure 10: Sales and volume use of parenteral vs oral subclasses in the hospital vs the community market excluding Japan, 2001-2005 - page 36
- Figure 11: Share of antibacterial sales and volumes across the US, EU5 and Pacific Rim by geographical area, 2001-2005 - page 38
- Figure 12: Ageing populations in the seven major markets, 1996-2016 - page 42
- Figure 13: US market shares of leading antibacterial brands by value, 2005 - page 60
- Figure 14: Japan market share of leading antibacterial brands by value, 2005 - page 69
- Figure 15: France market shares of leading antibacterial brands by value, 2005 - page 75
- Figure 16: Germany market shares of leading antibacterial brands by value, 2005 - page 84
- Figure 17: Italy market shares of leading antibacterial brands by value, 2005 - page 91
- Figure 18: Spain market shares of leading antibacterial brands by value, 2005 - page 97
- Figure 19: UK market shares of leading antibacterial brands by value, 2005 - page 102
- Figure 20: A range of bodies having an impact on drug prescription in - page 106
- the UK - page 106
- Figure 21: Summary of global and country-specific opportunities and threats - page 109
- Figure 22: Appropriate LCM strategy depends on time and financial investment - page 130
- Figure 23: Zithromax sales in the US, Q1/2005-Q2/2006 - page 131
- Figure 24: Pfizer's US marketing spend for azithromycin (Q3/2004-Q4/2005) is shifting from Zithromax to Zmax - page 132
- Figure 25: Generic azithromycin: US market share (first half of 2006) - page 134
- Figure 26: Pfizer still dominates the US azithromycin market (Q1/2005-Q2/2006) - page 135
- Figure 27: Regional amount of generic incursion for clarithromycin, 2005 - page 137
- Figure 28: US clarithromycin sales, 1H2003-1H2006 - page 139
- Figure 29: Regional amount of generic incursion for ceftriaxone, 2005 - page 141
- Figure 30: US sales of ceftriaxone, Q1/2005-Q2/2006 - page 142
- Figure 31: Roche: global antibacterial sales Q1/2005-Q2/2006 - page 143
Other users found this report page using the following search terms: bacterial antibiotic antibacterial resistance mrsa pyostacine resistance market antibacterials indications targocid zithromax meiact patent price
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.