Antidiabetics - Patent expiries and cost containment initiatives balanced by pipeline products
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Cardiovascular pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the antidiabetics market - page 4
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 14
- Market definition for this report - page 14
- Current market situation - page 15
- National markets - page 17
- The insulin market - page 19
- Lantus - page 20
- Humalog - page 21
- NovoRapid/NovoLog - page 21
- NovoLin - page 22
- Humulin - page 23
- Levemir - page 23
- Apidra - page 24
- Outlook - page 25
- The oral antidiabetics (OADs) market - page 27
- Thiazolidinediones - page 27
- Actos - page 27
- Avandia - page 31
- Sulfonylureas - page 31
- Biguanides - page 32
- Prandial glucose regulators (PGRs) - page 33
- Alpha-glucosidase inhibitors (AGIs) - page 35
- Outlook - page 37
- Thiazolidinediones - page 27
- Incretin mimetics - page 43
- Exenatide - page 43
- Outlook - page 44
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 45
- Current and future opportunities and threats in the antidiabetics market - page 45
- Global opportunities and threats - page 45
- Opportunities - page 45
- Threats - page 52
- US: current market assessment - page 56
- Overview - page 56
- US opportunities - page 58
- US threats - page 59
- Japan: current market assessment - page 64
- Overview - page 64
- Japan opportunities - page 65
- Japan threats - page 68
- EU5: current market assessment - page 73
- Overview - page 73
- EU5: opportunities and threats - page 74
- EU5 Opportunities - page 74
- EU5 Threats - page 75
- France: current market assessment - page 79
- Overview - page 79
- France: opportunities and threats - page 80
- France opportunities - page 80
- France threats - page 82
- Germany: current market assessment - page 85
- Overview - page 85
- Germany: opportunities and threats - page 86
- Germany opportunities - page 86
- Germany threats - page 87
- Italy: current market assessment - page 96
- Overview - page 96
- Italy: opportunities and threats - page 97
- Italy opportunities - page 97
- Italy threats - page 99
- Spain: current market assessment - page 102
- Overview - page 102
- Spain: opportunities and threats - page 103
- Spain opportunities - page 103
- Spain threats - page 105
- UK: current market assessment - page 108
- Overview - page 108
- UK: opportunities and threats - page 109
- UK opportunities - page 109
- UK threats - page 112
- Global opportunities and threats - page 45
- Summary of environmental issues affecting the antidiabetic market size - page 114
- Current and future opportunities and threats in the antidiabetics market - page 45
- CHAPTER 4 FORECAST ANALYSIS - page 118
- Assumptions and events - page 118
- Ongoing trends - page 118
- Increasing market size - page 118
- Trial results - page 118
- CHICAGO and PERISCOPE - page 118
- DREAM - page 119
- ACCORD - page 120
- ADOPT - page 120
- ORIGIN - page 120
- NAVIGATOR - page 120
- New product launches - page 121
- Byetta LAR - page 121
- Liraglutide (NN-2211) - page 122
- Januvia (sitagliptin, MK-0431) - page 122
- Galvus (vildagliptin, LAF-237) - page 122
- Metaglidasen (MBX-102) - page 123
- Exubera - page 123
- AIR inhalable insulin - page 123
- AERx-iDMS inhalable insulin - page 124
- Technosphere inhalable insulin - page 124
- Oral-lyn (Generex) - page 124
- Patent expiries - page 125
- Ongoing trends - page 118
- Limitations of data - page 126
- Forecasts - page 126
- Assumptions and events - page 118
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 127
- Introduction - page 127
- Case study 1 - Will changes in diabetes therapy outweigh the issues currently surrounding it? - page 127
- Issues with the current treatment of diabetes - page 127
- Current treatment is suboptimal - page 127
- Inappropriate definitions/monitoring - page 128
- Failing to address/prevent cardiovascular complications - page 128
- Unclear how best to treat Type 2 diabetes - page 129
- Compliance/polypharmacy/secondary drug failure - page 133
- Weight gain - page 134
- Changes in diabetes therapy - page 135
- Understanding of the pathophysiology of diabetes - page 135
- Awareness of insulin resistance and metabolic syndrome - page 136
- Insulin sensitizers versus insulin secretagogues - page 136
- Increased treatment with combination therapy - page 136
- Holistic approach - page 137
- Overlap between cardiology and endocrinology - page 138
- Proposed paradigm shift towards prevention - page 139
- Conclusions - page 140
- Diabetes could drive the primary care market - page 141
- New intervention points could create big new markets - page 141
- New understanding leads to new drug markets - page 141
- Biotechnology is potentially a big winner - page 141
- Issues with the current treatment of diabetes - page 127
- Case study 2 - A rich and diverse diabetes pipeline is expected to drive growth - page 143
- GLP-1 Agonists - page 143
- Mechanism of action - page 143
- Advantages - page 144
- Disadvantages - page 145
- Market potential - page 146
- DPP-4 inhibitors - page 147
- Mechanism of action - page 147
- Advantages - page 148
- Disadvantages - page 148
- Market potential - page 149
- Inhaled insulin - page 150
- Advantages - page 150
- Disadvantages - page 151
- Market potential - page 153
- Conclusion - page 155
- GLP-1 Agonists - page 143
- APPENDIX A - MAJOR BRAND KEY FACTS - page 156
- Insulin market data - page 156
- Humulin - page 156
- Humalog - page 157
- NovoLin - page 158
- NovoRapid/NovoLog - page 159
- Lantus - page 160
- TZDs market data - page 161
- Actos - page 161
- Avandia - page 162
- Sulfonylureas market data - page 163
- Amaryl - page 163
- Glucotrol XL - page 164
- Biguanide market data - page 165
- Glucophage and Glucophage XR - page 165
- Insulin market data - page 156
- APPENDIX B - page 166
- Bibliography - page 166
- Epidemiology - page 166
- Clinical trial data - page 167
- Report methodology - page 172
- Standard units - page 172
- Japanese market data - page 173
- Bibliography - page 166
- APPENDIX C - MARKET FORECAST DATA - page 174
- US forecasts - page 174
- Japan forecasts - page 179
- France forecasts - page 182
- Germany forecasts - page 186
- Italy forecasts - page 190
- Spain forecasts - page 194
- UK forecasts - page 198
- M5EU forecasts - page 201
- Global forecasts - page 206
- About Datamonitor - page 214
- About Datamonitor Healthcare - page 214
- About the Cardiovascular Disease analysis team - page 215
- Disclaimer - page 216
- List of Tables
- Table 1: Global sales in the antidiabetic market by drug class, 2005 - page 15
- Table 2: Global sales of the leading branded insulin families, 2004-05 - page 19
- Table 3: Global sales of the leading branded TZDs, 2004-05 - page 27
- Table 4: Global sales of the leading branded sulfonylureas, 2004-05 - page 32
- Table 5: Global sales of the leading branded biguanide, 2004-05 - page 33
- Table 6: Global sales of the leading branded PGRs, 2004-05 - page 35
- Table 7: Global sales of the leading branded AGIs, 2004-05 - page 37
- Table 8: Prevalence of obesity in the seven major markets by age (000s), 2005 - page 49
- Table 9: US sales and growth of drug classes - page 57
- Table 10: Japan sales and growth of drug classes - page 64
- Table 11: EU5 sales and growth of drug classes - page 73
- Table 12: French sales and growth of drug classes - page 79
- Table 13: German sales and growth of drug classes - page 85
- Table 14: Italian sales and growth of drug classes - page 96
- Table 15: Spanish sales and growth of drug classes - page 102
- Table 16: UK sales and growth of drug classes - page 108
- Table 17: The ten clinical areas of the Quality Outcome Framework, as outlined in the GMS contract, 2005 - page 111
- Table 18: Patent expiry dates used in forecasting antidiabetics market - page 126
- Table 19: Humulin: key facts - page 156
- Table 20: Humalog: key facts - page 157
- Table 21: NovoLin: key facts - page 158
- Table 22: NovoLog: key facts - page 159
- Table 23: Lantus: key facts - page 160
- Table 24: Actos: key facts - page 161
- Table 25: Avandia: key facts - page 162
- Table 26: Amaryl: key facts - page 163
- Table 27: Glucotrol XL: key facts - page 164
- Table 28: Glucophage and Glucophage XR: key facts - page 165
- Table 29: US antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 174
- Table 30: Japanese antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 179
- Table 31: French antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 182
- Table 32: German antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 186
- Table 33: Italian antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 190
- Table 34: Spanish antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 194
- Table 35: UK antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 198
- Table 36: M5EU antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 201
- Table 37: Global antidiabetic sales forecasts ($m; 2005 figures are actuals) - page 206
- List of Figures
- Figure 1: Sales and growth for antidiabetic drug classes in the seven major markets, 2004-05 - page 16
- Figure 2: Share of antidiabetics market represented by each of the seven major markets in 2005 - page 17
- Figure 3: Pioglitazone's effects on triglyceride and HDL cholesterol levels - page 29
- Figure 4: Proportion of population 20-39 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 46
- Figure 5: Proportion of population 40-59 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 47
- Figure 6: Proportion of population 60-79 years of age, 2003 and 2015 and prevalence of diabetes in this age group, 2003 - page 48
- Figure 7: Annual US sales of the antidiabetic drug classes, 2002-05 - page 57
- Figure 8: Annual Japan sales of the antidiabetic drug classes, 2002-05 - page 65
- Figure 9: Annual EU5 sales of the antidiabetic drug classes, 2002-05 - page 74
- Figure 10: Annual French sales of the antidiabetic drug classes, 2002-05 - page 80
- Figure 11: Annual German sales of the antidiabetic drug classes, 2002-05 - page 86
- Figure 12: A fall in reference prices is likely to lead to greater use of generics - page 91
- Figure 13: Annual Italian sales of the antidiabetic drug classes, 2002-05 - page 97
- Figure 14: Annual Spanish sales of the antidiabetic drug classes, 2002-05 - page 103
- Figure 15: Although generic sales and volume use have increased over the last ten years, the generics market only accounts for a small proportion of the Spanish pharmaceutical market - page 104
- Figure 16: Annual UK sales of the antidiabetic drug classes, 2002-05 - page 109
- Figure 17: Summary of global and EU specific opportunities and threats affecting the diabetes market, 2006 - page 115
- Figure 18: Summary of US and Japan-specific opportunities and threats affecting the diabetes market, 2006 - page 116
- Figure 19: Summary of country-specific opportunities and threats affecting the diabetes market, 2006 - page 117
Other users found this report page using the following search terms: diabetes patent expiry glucophage sales cost pioglitazone novorapid uk novolin containment
If you can't find a report that meets your needs contact LeadDiscovery. We are one of the few report providers with extensive drug development experience and we frequently use this knowledge to help clients source the most appropriate reports or produce reports for them from scratch.