Cancer Vaccines Measuring Market Potential
Overview
This report provides an overview of the emerging market for cancer vaccines and measures their potential impact on a number of cancer markets. Vaccine product candidates are discussed within the context of the disease areas they are attempting to penetrate and include: melanoma, prostate cancer, colorectal cancer, lung cancer, breast cancer, and pancreatic cancer.
There are currently over twenty Phase III trials ongoing for various indications and new approvals may come as early as 2005. The value of the market for cancer vaccines has the potential to reach $6 billion by 2010.
This report is designed to provide the information, insight and analysis key to an understanding of how cancer vaccines will impact the biotech and pharmaceutical marketplace. Those in the field of cancer therapy and cancer vaccines will want to read this report in order to better understand where and how vaccines will make a difference in future cancer therapy.
This 232-page report:
- Gauges the potential of key vaccine products nearing commercialization.
- Analyzes the results of key clinical trials as a means of determining future success in the market.
- Forecasts financial growth of the cancer vaccine market through 2010.
- Assesses the competition from cytotoxics and other biologics in six key cancer markets.
- Provides valuable data concerning patient populations, survival rates, and global epidemiology
- Identifies and discusses trends and issues that will have a significant impact on the cancer vaccine market.
- Profiles the leading companies in the field and provides valuable information and analysis concerning their lead vaccine candidates.
Table of Contents
- Table of Contents
- 1 Methodology and Executive Summary
- 1.1 Report Objectives
- 1.2 Research Methodology
- 1.3 Executive Summary
- Table 1.1 Value of the Cancer Vaccine Market, by Type, 2010
- 2 The Global Impact of Cancer
- 2.1 United States
- 2 The Global Impact of Cancer
- Table 2.1 Estimated New Cancer Cases and Deaths, US 2004
- Graph 2.1 Deadliest Cancers in the US 2004
- Graph 2.2 Leading Sites of New Cancer Cases, Male 2004
- Graph 2.3 Leading Sites of New Cancer Cases, Female 2004
- 2.2 The World
- Table 2.2 Total Incidence of Cancer, by Region 2000
- Graph 2.4 Regions Most-Effected by Cancer, 2000
- Table 2.3 Rates of Incidence and Deaths for Select Cancers Worldwide, 2000
- 2.3 Survival Rates
- Table 2.4 Five-Year Survival Rates for Select Cancers by Stage at Diagnosis, US 2000
- 2.4 Economic Impact
- Table 2.5 The Economic Impact of Cancer in the US
- 2.5 Epidemiology of Select Cancers
- 2.5.1 Colorectal Cancer
- 2.5.2 Lung Cancer
- 2.5 Epidemiology of Select Cancers
- Table 2.6 Global Lung Cancer Incidence in Select Regions, 2000
- 2.5.3 Prostate Cancer
- Graph 2.5 Global Prostate Cancer Incidence, Select Regions, 2000
- 2.5.4 Breast Cancer
- Table 2.7 Breast Cancer Survival Rates, by Stage
- Table 2.8 Breast Cancer Overall Survival Rate
- 2.5.5 Pancreatic Cancer
- Graph 2.6 Pancreatic Cancer Incidence, Select Regions, 2000
- 2.5.6 Melanoma
- Graph 2.7 Incidence of Melanoma, US vs. Rest of World, 2000
- 3 Introduction to Cancer Vaccines
- 3.1 The Immune System and Cancer
- 3.2 The Basics
- 3.3 Unmet Need in Cancer Therapy
- 3.4 Why Vaccines?
- 3.5 Early Efforts at Cancer Vaccines
- 3.6 Types of Vaccines
- 3.6.1 Viral Vectors and DNA Vaccines
- 3.6.2 Antigen/adjuvant Vaccines
- 3.6.3 Whole-cell Tumor Vaccines
- 3.6.4 Anti-Idiotype Vaccines
- 3.6.5 Dendritic Cell Vaccines
- 3 Introduction to Cancer Vaccines
- Table 3.1 Key Vaccines Nearing FDA Approval
- 4 Vaccines and the Future of the Colorectal Cancer Therapy Market
- 4.1 Current Treatment of Colorectal Cancer
- 4 Vaccines and the Future of the Colorectal Cancer Therapy Market
- Table 4.1 The Stages of Colorectal Cancer
- 4.1.1 Surgery
- 4.1.2 Radiation Therapy
- 4.1.3 Cytotoxics
- 4.1.4 Biologics
- 4.2 An Overview of the Market for Colorectal Cancer Therapies
- Table 4.2 Leading Drugs for Treatment of Colorectal Cancer
- Table 4.3 Sales of New Biologic Therapies for Colorectal Cancer 2004
- Graph 4.1 Growth of the Colorectal Cancer Therapy Market, 2000-2004
- Graph 4.2 The Colorectal Cancer Therapy Market, Cytotoxics vs. Biologics 2004
- 4.2.1 Cytotoxics
- 4.2.1.1 Eloxatin
- 4.2.1.1.1 Market Impact
- 4.2.1.2 Camptosar
- 4.2.1.2.1 Market Impact
- 4.2.1.1 Eloxatin
- 4.2.2 Emerging Biologics with Strong Market Potential
- 4.2.2.1 Avastin
- 4.2.2.1.1 Market Impact
- 4.2.2.2 Erbitux
- 4.2.2.2.1 Market Impact
- 4.2.2.1 Avastin
- 4.3 Unmet Need in Colorectal Cancer Therapy
- 4.4 The Promise of Vaccines for Colorectal Cancer
- 4.2.1 Cytotoxics
- Table 4.4 Therapeutic Vaccine Pipeline for Colorectal Cancer
- Graph 4.3 Therapeutic Vaccines for Colorectal Cancer, by Clinical Trial Phase
- 4.4.1 Clinical Trial Strategies
- 4.4.2 Oncovax
- 4.4.2.1 Clinical Trials
- 4.4.3 IGN101
- 4.4.3.1 Clinical Trials
- 4.4.4 Oncophage
- 4.4.4.1 Clinical Trials
- 4.4.5 Avicine
- 4.4.5.1 Clinical Trials
- 4.4.6 Theratope
- 4.4.6.1 Clinical Trials
- 4.5 Market Analysis: Colorectal Cancer Therapy Market and the Prospects for Vaccines
- 4.6 Financial Forecast for Colorectal Cancer Vaccines
- Table 4.5 Oncovax Sales Forecast 2005-2010 ($ mn)
- 5 Vaccines and the Future of Prostate Cancer Therapy
- 5.1 Current Treatment of Prostate Cancer
- 5 Vaccines and the Future of Prostate Cancer Therapy
- Table 5.1 The Stages of Prostate Cancer
- 5.1.1 Surgery
- 5.1.2 Radiation Therapy
- 5.1.3 Hormone Therapy
- 5.1.4 Cytotoxics
- Table 5.2 Best-Selling Hormone Therapies for Prostate Cancer
- 5.2 An Overview of the Market for Prostate Cancer Therapies
- Table 5.3 Leading Drugs for Treatment of Prostate Cancer
- Graph 5.1 Value of the Prostate Therapy Market 2000-2003
- 5.3 New Biologic Competitors in Prostate Cancer Therapy
- 5.4 Unmet Need in Prostate Cancer Therapy
- 5.5 The Promise of Vaccines for Prostate Cancer
- Table 5.4 Therapeutic Vaccine Pipeline for Prostate Cancer
- Graph 5.2 Therapeutic Vaccines for Prostate Cancer, by Clinical Trial Phase
- 5.5.1 Clinical Trial Strategies
- 5.5.2 Provenge
- 5.5.2.1 Clinical Trials
- 5.5.3 GVAX
- 5.5.3.1 Clinical Trials
- 5.5.4 MVA-Muc1- IL2
- 5.5.4.1 Clinical Trials
- 5.5.5 Prostvac-VF
- 5.5.5.1 Clinical Trials
- 5.6 Market Analysis: Prostate Cancer Therapy Market and the Prospects for Vaccines
- 5.7 Financial Forecast for Prostate Cancer Vaccines
- Table 5.5 Prostate Cancer Vaccines Sales Forecast 2006-2010
- Graph 5.3 Prostate Cancer Vaccine Market Share 2007
- Graph 5.4 Prostate Cancer Vaccine Market Share 2010
- 6 Vaccines and the Future of the Lung Cancer Therapy Market
- 6.1 Current Treatment of Lung Cancer
- 6 Vaccines and the Future of the Lung Cancer Therapy Market
- Table 6.1 Stages of Lung Cancer
- 6.1.1 Surgery
- 6.1.2 Cytotoxics
- 6.1.3 Radiation Therapy
- 6.2 An Overview of the Market for Lung Cancer Therapies
- Table 6.2 Leading Drugs for Treatment of Lung Cancer
- Graph 6.1 Value of the Lung Cancer Therapy Market 2000-2003
- Table 6.3 Major Uses for Popular Anti-Cancer Agents
- Table 6.4 Sales of New Targeted Therapies for Lung Cancer 2004
- Table 6.5 Therapeutic Vaccine Pipeline for Lung Cancer
- Graph 6.2 Therapeutic Vaccines for Lung Cancer, by Clinical Trial Phase
- 6.2.1 Cytotoxics
- 6.2.2 New Targeted Therapies Increase Competition
- 6.2.2.1 Iressa
- 6.2.2.2 Tarceva
- 6.3 Unmet Need in Lung Cancer Therapy
- 6.4 Emerging Vaccines for Lung Cancer
- 6.4.1 Clinical Trial Strategies
- 6.4.2 IGN101
- 6.4.2.1 Clinical Trials
- 6.4.3 IMC-BEC2
- 6.4.3.1 Clinical Trials
- 6.4.4 BLP25
- 6.4.4.1 Clinical Trials
- 6.4.5 GVAX
- 6.4.5.1 Clinical Trials
- 6.5 Market Analysis: Lung Cancer Therapy Market and the Prospects for Vaccines
- 6.6 Financial Forecast for Lung Cancer Vaccines
- Table 6.6 Lung Cancer Vaccines Sales Forecast 2006-2010
- Graph 6.3 Lung Cancer Vaccine Market Share 2007
- Graph 6.4 Lung Cancer Vaccine Market Share 2010
- 7 Vaccines and the Future of Breast Cancer Therapy
- 7.1 Current Treatment of Breast Cancer
- 7 Vaccines and the Future of Breast Cancer Therapy
- Table 7.1 Stages of Breast Cancer
- 7.1.1 Surgery
- 7.1.2 Radiation Therapy
- 7.1.3 Hormone Therapy
- 7.1.4 Cytotoxics
- 7.1.5 Targeted Therapies
- 7.2 An Overview of the Market for Breast Cancer Therapies
- Table 7.2 Leading Drugs for Treatment of Breast Cancer
- Graph 7.1 Breast Cancer Therapies Market Share 2003
- 7.3 Unmet Need in Breast Cancer Therapy
- 7.4 Emerging Vaccines for Breast Cancer
- Table 7.3 Therapeutic Vaccine Pipeline for Lung Cancer
- Graph 7.2 Therapeutic Vaccines for Breast Cancer, by Clinical Trial Phase
- 7.4.1 Theratope
- 7.4.1.1 Clinical Trials
- 7.4.2 IGN101
- 7.4.2.1 Clinical Trials
- 7.5 Market Analysis: Breast Cancer Therapy Market and the Prospects for Breast Cancer Vaccines
- 7.4.1 Theratope
- Table 7.4 Breast Cancer Vaccines Sales Forecast 2007-2011
- 8 Vaccines and the Future of Pancreatic Cancer Therapy
- 8.1 Current Treatment of Pancreatic Cancer
- 8 Vaccines and the Future of Pancreatic Cancer Therapy
- Table 8.1 Stages of Pancreatic Cancer
- 8.1.1 Surgery
- 8.1.2 Radiation Therapy
- 8.1.3 Cytotoxics
- 8.2 Biologics in Development
- Table 8.2 Biologics in Clinical Development for Pancreatic Cancer
- 8.3 An Overview of the Market for Pancreatic Cancer Therapy
- Table 8.3 Leading Drugs for Treatment of Pancreatic Cancer
- 8.4 Unmet Need in Pancreatic Cancer Therapy
- 8.5 Emerging Vaccines for Pancreatic Cancer
- Table 8.4 Therapeutic Vaccine Pipeline for Pancreatic Cancer
- Graph 8.1 Therapeutic Vaccines for Pancreatic Cancer, by Clinical Trial Phase
- 8.5.1 Clinical Trial Strategies
- 8.5.2 INSEGIA (G17DT)
- 8.5.2.1 Clinical Trials
- 8.5.3 Virulizin
- 8.5.3.1 Clinical Trials
- 8.5.4 PANVAC-VF
- 8.5.4.1 Clinical Trials
- 8.5.5 Avicine
- 8.5.5.1 Clinical Trials
- 8.6 Market Analysis: Pancreatic Cancer Therapy Market and the Prospects for Vaccines
- 8.7 Financial Forecast for Pancreatic Cancer Vaccines
- Table 8.5 Pancreatic Vaccine Approvals and Their Initial Indications
- Table 8.6 Pancreatic Cancer Vaccines Sales Forecast 2006-2010
- 9 Vaccines and the Future of Melanoma Therapy
- 9.1 Current Treatment of Melanoma
- 9 Vaccines and the Future of Melanoma Therapy
- Table 9.1 Stages of Melanoma
- 9.1.1 Surgery
- 9.1.2 Chemotherapy
- 9.1.3 Radiation Therapy
- 9.1.4 Biologics
- Table 9.2 Currently Available Biological Therapies for Melanoma
- 9.2 An Overview of the Market for Melanoma Therapy
- Table 9.3 Single-Agent Cytotoxics for Melanoma
- Table 9.4 Leading Drugs for Treatment of Melanoma
- 9.3 Unmet Need
- 9.4 Emerging Vaccines for Melanoma
- Table 9.5 Therapeutic Vaccine Pipeline for Melanoma
- 9.4.1 Canvaxin
- 9.4.1.1 Clinical Trials
- 9.4.2 Oncophage
- 9.4.2.1 Clinical Trials
- 9.4.3 Allovectin-7
- 9.4.3.1 Clinical Trials
- 9.5 Disappointments and Challenges in Melanoma Vaccine Development
- 9.5.1 GMK
- 9.5.2 Melacine
- 9.6 Market Analysis: Melanoma and the Prospects for Vaccines
- 9.4.1 Canvaxin
- Table 9.6 Competition in the Melanoma Therapy Market
- 9.7 Financial Forecast for Melanoma Vaccines
- Table 9.7 Melanoma Vaccines Sales Forecast 2006-2010
- 10 Company Briefs
- Aastrom Biosciences
- Advaxis
- Table 10.1 Advaxis� Cancer Vaccine Pipeline
- AlphaVax
- Antigenics
- Table 10.2 Clinical Development Status of Oncophage
- Aphton Corporation
- Aventis Pasteur
- AVI Biopharma
- Biomira
- Table 10.3 Biomira�s Vaccine Pipeline
- Biovex
- CancerVax Corporation
- Cell Genesys
- Table 10.4 Clinical Development of GVAX
- Corixa
- Cytogen Corporation
- Dendreon
- Table 10.5 Dendreon�s Vaccine Pipeline
- Epimmune
- Favrille Inc.
- GeneMax
- Genitope Corporation
- Genzyme (Oncology)
- Table 10.6 Genzyme�s Vaccine Pipeline
- Geron Corporation
- GlaxoSmithKline Biologicals
- IDM, Inc.
- Table 10.7 IDM�s Vaccine Pipeline
- Igeneon
- Table 10.8 Igeneon�s Vaccine Pipeline
- ImClone Systems Incorporated
- Intracel Holdings Corporation
- Large Scale Biology Corporation
- Lorus Therapeutics
- Maxygen
- MedImmune
- Merck & Co.
- Northwest Biotherapeutics
- Oxford BioMedica plc
- Pharmexa A/S
- Table 10.9 Pharmexa�s Cancer Vaccine Pipeline
- Progenics Pharmaceuticals
- Table 10.10 Progenics� Cancer Vaccine Pipeline
- Therion Biologics Corporation
- Table 10.11 Therion�s Cancer Vaccine Pipeline
- Transgene S.A.
- United Biomedical
- Vical Incorporated
- Xcyte Therapies Inc.
- Table 10.12 Xcyte Therapies Vaccine Pipeline
- YM Biosciences Inc.
- Zycos
- Appendix
- Table I Cancer Vaccines in Clinical Development
- Table II Anticipated Launches of Emerging Cancer Vaccines
- Graph I Vaccines in Preclinical to Phase III Development Stages, by Indication
- Graph II Leading Companies in Field of Cancer Vaccines
- Graph III Number of Vaccine Indications in Clinical Trials, by Phase
- Graph IV Leading Cancer Indications for Vaccines
- Graph V Vaccines with Greatest Number of Potential Indications
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