Pulmonary Arterial Hypertension - A small market gets big attention
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- About the cardiovascular pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- CHAPTER 2 PULMONARY ARTERIAL HYPERTENSION OVERVIEW - page 11
- Pulmonary arterial hypertension background - page 11
- Pulmonary arterial hypertension is a deadly disease - page 12
- Epidemiology - page 12
- Idiopathic pulmonary arterial hypertension rates support market estimates - page 12
- An estimated 146,000 patients in US, Europe, and Japan - page 13
- Pulmonary arterial hypertension severity is segmented into four classes - page 14
- Presentation and diagnosis of pulmonary arterial hypertension - page 15
- Breakdown by class - page 16
- Current treatment of pulmonary arterial hypertension - page 17
- Three approved drug classes have improved outlook for patients. - page 17
- Unmet need in pulmonary arterial hypertension management - page 18
- Efficacy, improved delivery, and reduced costs linked needs in treatment - page 18
- Combination therapy unproven, but growing in popularity - page 19
- Increased awareness needed, particularly for oral therapy success - page 19
- Greater understanding of patient population required - page 20
- CHAPTER 3 CURRENT PULMONARY ARTERIAL HYPERTENSION THERAPIES - page 21
- Tracleer (bosentan) - page 21
- BREATHE-1 trial data forms basis for approval - page 22
- Bosentan has also been supported by several other BREATHE studies - page 23
- Datamonitor comment - page 23
- Flolan (epoprostenol sodium) - page 24
- Pivotal study, follow-up studies, show survival benefit - page 24
- Datamonitor comment - page 25
- Remodulin (treprostinil) - page 27
- Bioequivalence data used for intravenous extension - page 28
- Phase IV clinical study data looks promising - page 28
- Datamonitor comment - page 29
- Ventavis (iloprost) - page 31
- Clinical trial data - page 32
- Datamonitor comment - page 33
- Revatio (sildenafil) - page 33
- Clinical trial data - page 34
- Cost of Revatio - page 34
- Datamonitor comment - page 35
- Benchmarking therapies - page 36
- Tracleer (bosentan) - page 21
- CHAPTER 4 PULMONARY ARTERIAL HYPERTENSION THERAPIES IN DEVELOPMENT - page 38
- Thelin (sitaxsentan) - page 38
- Clinical data supports benefit - page 39
- STRIDE-1 - page 39
- STRIDE-2 - page 39
- Additional trials - page 40
- Datamonitor comment - page 40
- Clinical data supports benefit - page 39
- Ambrisentan - page 41
- Clinical data points to potential class winner - page 42
- ARIES-1 - page 42
- ARIES-2 - page 43
- Datamonitor comment - page 43
- Clinical data points to potential class winner - page 42
- Tadalafil - page 44
- Datamonitor comment - page 44
- Inhaled treprostinil - page 45
- Oral treprostinil also holds considerable promise - page 46
- Datamonitor comment - page 47
- Aviptadil - page 48
- Datamonitor comment - page 48
- Other early stage therapies - page 49
- UK-369003 - page 49
- ABT-306552 - page 49
- PRX-08066 - page 49
- PulmoLAR - page 50
- Gleevec (imatinib) - page 50
- Thelin (sitaxsentan) - page 38
- CHAPTER 5 PULMONARY ARTERIAL HYPERTENSION MARKET FORECAST - page 51
- Oral therapies forecast assumptions - page 51
- Prostacyclin forecast assumptions - page 53
- Timings of pulmonary arterial hypertension launches - page 54
- PAH market forecasts, 2005-2014 - page 55
- APPENDIX - page 57
- About Datamonitor - page 57
- About Datamonitor Healthcare - page 57
- Disclaimer - page 59
- About Datamonitor - page 57
- List of Tables
- Table 1: Estimated PAH prevalence, US, Europe, and Japan, 2005 - page 14
- Table 2: Current breakdown of presenting PAH patients, by severity - page 16
- Table 3: Currently available PAH therapies and 2004 sales - page 21
- Table 4: Timeline of product launches and other key regulatory events - page 54
- Table 5: US PAH market forecast, $m, 2005-2014 - page 55
- Table 6: Global PAH market forecast, $m, 2005-2014 - page 56
- List of Figures
- Figure 1: ProDose (top) and I-neb AAD systems (bottom) - page 31
- Figure 2: Position of currently available therapies, by disease severity - page 36
- Figure 3: Comparative strengths and weaknesses of PAH therapies, including late-stage therapies - page 37
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