Antihypertensives - Two Years to Shape the Market?
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the hypertension market - page 4
- CHAPTER 2 MARKET DEFINITION AND OVERVIEW - page 11
- Market definition and overview for this report - page 11
- Hypertension - page 12
- Disease overview - page 12
- Epidemiology - page 13
- Treatment options; the antihypertensive drug classes - page 15
- Drugs that inhibit the renin-angiotensin system (RAS) - page 16
- Drugs that do not inhibit the renin-angiotensin system (RAS) - page 31
- Other classes of antihypertensive drugs - page 33
- CHAPTER 3 COUNTRY MARKET ASSESSMENTS - page 35
- Current and future opportunities and threats in the antihypertensives market - page 35
- The global market: overview, opportunities and threats - page 35
- Overview - page 35
- National markets - page 41
- The global movers and shakers - page 43
- Global opportunities - page 44
- Global threats - page 54
- US market: overview, opportunities and threats - page 54
- Overview - page 54
- US market issues - page 56
- Japan: overview, opportunities and threats - page 67
- Overview - page 67
- Japanese market issues - page 69
- European Union: overview, opportunities and threats - page 79
- Overview - page 79
- EU market issues - page 82
- The global market: overview, opportunities and threats - page 35
- Current and future opportunities and threats in the antihypertensives market - page 35
- CHAPTER 4 FORECAST ANALYSIS - page 88
- Assumptions and events - page 88
- Ongoing trends - page 88
- Increasing market size - page 88
- Increasing use of fixed-dose combinations - page 88
- Trial results - page 88
- New product launches - page 91
- S-amlodipine - page 91
- SPP100 (aliskiren) - page 92
- Caduet - page 92
- Patent issues - page 93
- ARB patent expiries - page 94
- CCB patent expiries - page 95
- Beta-blocker patent expiries - page 96
- ACE inhibitor patent expiries - page 96
- Other patent expiries - page 96
- Additional indications - page 97
- Irbesartan gains congestive heart failure indication - page 98
- Valsartan gains additional diabetes indication - page 99
- Ongoing trends - page 88
- Methodology - page 99
- Forecasts - page 99
- Assumptions and events - page 88
- CHAPTER 5 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDIES - page 100
- Introduction - page 100
- Case study 1 - page 100
- Novartis and the "renin revolution" - page 100
- Case study 2 - page 113
- Clinical trial data and the potential to change prescribing habits - page 113
- Case study 3 - page 122
- EU healthcare reforms: a tale of two countries - page 122
- Case study 1 - page 100
- Introduction - page 100
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 134
- Global hypertension market data - page 134
- Major brand facts - page 134
- C7 BBs - page 134
- C8 CCBs - page 136
- C9 ACEIs - page 138
- C9 ARBs - page 140
- Anatomical Therapeutic Chemical (ATC) classification - page 143
- Major brand facts - page 134
- Global hypertension market data - page 134
- APPENDIX B - page 145
- Bibliography - page 145
- Hypertension management guidelines - page 145
- JNC 7 - page 145
- ESH/ESC - page 145
- WHO/ISH - page 145
- BHS-IV - page 145
- References - page 146
- Hypertension management guidelines - page 145
- Report methodology - page 148
- General - page 148
- Japan sales data - page 148
- Key opinion leaders - page 148
- About Datamonitor - page 149
- About Datamonitor Healthcare - page 149
- About the Cardiovascular Disease analysis team - page 150
- Disclaimer - page 151
- Glossary - page 152
- Bibliography - page 145
- APPENDIX C - MARKET FORECAST DATA - page 153
- US forecasts - page 153
- Japan forecasts - page 158
- France forecasts - page 162
- Germany forecasts - page 167
- Italy forecasts - page 172
- Spain forecasts - page 177
- UK forecasts - page 182
- M5EU forecasts - page 187
- Global forecasts - page 194
- List of Tables
- Table 1: A comparison of the various forms of hypertension recognized by three of the key hypertension guidelines - page 13
- Table 2: Sales, sales growth and market share of the ARBs in the seven major markets, 2005 - page 19
- Table 3: Sales, growth and market share for antihypertensive drug classes in the seven major markets, 2003-04 - page 37
- Table 4: ARB sales in the seven major markets, 2004 - page 44
- Table 5: Prevalence of obesity in the seven major markets by age (000s), 2003 - page 48
- Table 6: US sales and growth of antihypertensive drug classes - page 55
- Table 7: Japan sales and growth of antihypertensive drug classes - page 68
- Table 8: M5EU sales and growth of antihypertensive drug classes - page 80
- Table 9: Country-specific sales for antihypertensive drugs in the five major European countries - page 82
- Table 10: Patent expiry dates used in forecasting the antihypertensive market across the seven major markets - page 94
- Table 11: Comparison of hypertension levels from the BHSIV guidelines and the GMS contract QOF - page 128
- Table 12: Coreg: key facts - page 134
- Table 13: Toprol-XL: key facts - page 135
- Table 14: Tenormin; key facts - page 135
- Table 15: Inderal: key facts - page 136
- Table 16: Norvasc: key facts - page 136
- Table 17: Plendil: key facts - page 137
- Table 18: Cardizem LA: key facts - page 137
- Table 19: Adalat: key facts - page 138
- Table 20: Altace: key facts - page 138
- Table 21: Aceon: key facts - page 139
- Table 22: Accupro: key facts - page 139
- Table 23: Atacand; key facts - page 140
- Table 24: Teveten: key facts - page 140
- Table 25: Avapro: key facts - page 141
- Table 26: Cozaar: key facts - page 141
- Table 27: Benicar: key facts - page 142
- Table 28: Micardis: key facts - page 142
- Table 29: Diovan: key facts - page 143
- Table 30: Antihypertensive classifications - page 144
- Table 31: US: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 153
- Table 32: Japan: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 158
- Table 33: France: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 162
- Table 34: Germany: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 167
- Table 35: Italy: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 172
- Table 36: Spain: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 177
- Table 37: UK: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 182
- Table 38: M5EU: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 187
- Table 39: Global: antihypertensive sales forecasts ($m), 2006-14, with CAGR between 2004-14 (%) - page 194
- List of Figures
- Figure 1: Prevalence of hypertension broken down by age, 2004-15 - page 14
- Figure 2: The renin-angiotensin system - page 16
- Figure 3: Angiotensin II is a cardiovascular risk factor with direct tissue effects - page 17
- Figure 4: Recommendations for the combining of blood pressure lowering drugs (AB/CD rule) (adapted from Williams et al., 2004) - page 27
- Figure 5: Pharmaceutical sales in the seven major markets, 2004 - page 36
- Figure 6: Market share by antihypertensive class, 2001 and 2004 in the seven major markets - page 38
- Figure 7: Sales, growth and market share for antihypertensive drug classes in the seven major markets, 2003-04 - page 39
- Figure 8: Global sales values for the antihypertensive classes, 2001-04 - page 40
- Figure 9: Average ex-manufacturer prices of the leading brands of each antihypertensive class across all country markets, 2001-04 - page 41
- Figure 10: Share of antihypertensives market represented by each of the seven major markets, 2004 - page 42
- Figure 11: Proportion of population aged 20-39 years, 2004 and 2015, and prevalence of hypertension in this age group in the seven major markets, 2004 - page 45
- Figure 12: Proportion of population aged 40-59 years, 2004 and 2015, and prevalence of hypertension in this age group in the seven major markets, 2004 - page 46
- Figure 13: Proportion of population aged 60-79 years, 2004 and 2015, and prevalence of hypertension in this age group in the seven major markets, 2004 - page 47
- Figure 14: Annual US sales of antihypertensive drug classes, 2001-04 - page 56
- Figure 15: JNC6 and JNC7 compared; classification of blood pressure levels - page 58
- Figure 16: Compelling indications for individual drug classes - page 60
- Figure 17: Annual Japanese sales of antihypertensive drug classes, 2001-04 - page 69
- Figure 18: Annual M5EU sales of antihypertensive drug classes, 2001-04 - page 81
- Figure 19: Unlike the ARBs, SPP100 produces significant Reductions in plasma renin activity (PRA) - page 102
- Figure 20: Clinical development activity with SPP100 (aliskiren), 2005 - page 103
- Figure 21: Speedel's Phase II study on SPP100 - page 104
- Figure 22: Novartis's Phase IIb study on SPP100 (Study 2201) - page 105
- Figure 23: Systolic blood pressure (SBP) reductions during Novartis's SPP100 plus Diovan study (Study 2203) - page 106
- Figure 24: Diastolic blood pressure (DBP) reductions during Novartis's SPP100 plus Diovan study (Study 2203) - page 107
- Figure 25: SPP100; building the brand & differentiating it in the market - page 111
- Figure 26: ASCOT study design - page 114
- Figure 27: ASCOT trial profile - page 115
- Figure 28: Domestic and Foreign Sales of German Pharmaceutical Companies - page 125
- Figure 29: QOF eleven clinical areas (points) - page 127
- Figure 30: The impact of healthcare reforms in Germany on sales growth within the antihypertensive drug market - page 129
- Figure 31: The impact of healthcare reforms in the UK on sales growth within the antihypertensive drug market - page 130
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