Pipeline Insight: Antithrombotics - Anticoagulants and Antiplatelets Have Blockbuster Potential
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the cardiovascular pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Scope of the analysis - page 3
- Datamonitor insight into the antithrombotics market - page 3
- The R&D pipeline for antithrombotics is a Phase II-heavy cornucopia of novel agents - page 4
- Of the three antithrombotic classes only the anticoagulant class and the antiplatelet class comprise drugs with blockbuster potential - page 4
- There is little commercial potential for novel parenteral anticoagulants and for thrombolytics - page 5
- Lifecycle management of established brands erects market entry barriers for novel agents - page 6
- CHAPTER 2 PIPELINE DYNAMICS - page 25
- Pipeline overview - page 25
- Antithrombotics segmented by class - page 33
- Anticoagulants by drug class - page 33
- Antiplatelets by drug class - page 35
- Thrombolytics by drug class - page 38
- Antithrombotics segmented by company - page 39
- Key companies involved in the antithrombotics pipeline - page 43
- Overview - page 43
- Antithrombotics segmented by class - page 33
- Pipeline overview - page 25
- CHAPTER 3 PATIENT POTENTIAL - page 45
- Definition of antithrombotic market - page 46
- Antithrombotic launch indications - page 50
- Venous thrombosis - page 50
- VTE prophylaxis in patients undergoing major orthopedic surgery - page 50
- Treatment and secondary prevention of acute venous thromboembolism - page 52
- Arterial thrombosis - page 56
- Coronary thrombosis - page 56
- Cerebrovascular thrombosis - page 60
- Stroke treatment - page 60
- Stroke prevention in atrial fibrillation patients (SPAF) - page 62
- Peripheral thrombosis - page 65
- Peripheral arterial disease (PAD) - page 65
- Venous thrombosis - page 50
- Marketability considerations: unmet needs, barriers to market entry and uptake - page 70
- Anticoagulants - page 70
- Unmet needs: parenteral anticoagulants - page 70
- Unmet needs: oral anticoagulants - page 71
- Unmet need: increased physician awareness of VTE - page 73
- Points of consideration: factors influencing market entry and uptake - page 74
- Unmet needs summary - page 78
- Antiplatelets - page 80
- Unmet needs - page 80
- Unmet need for rapid onset of action in interventional cardiology - page 84
- Unmet need: increased physician awareness for the need of therapy for PAD - page 85
- Points of consideration: factors influencing market entry and uptake - page 86
- Unmet needs summary - page 88
- Thrombolytics - page 89
- Unmet needs - page 90
- Points of consideration: thrombolytic Indications - page 95
- Anticoagulants - page 70
- CHAPTER 4 R&D APPROACH - page 103
- Classification of pipeline products - page 104
- Anticoagulants - page 104
- Hemostasis and the coagulation cascade - page 104
- Indirect thrombin inhibitors - page 107
- Unfractionated heparin (UFH) - page 107
- Low molecular weight heparin (LMWH) - page 108
- Direct thrombin inhibitors (DTIs) - page 109
- Factor IXa inhibitors - page 111
- Factor Xa inhibitors - page 112
- Factor VIIa inhibitors/tissue factor pathway inhibitors - page 118
- Enhancing natural anticoagulant activity - page 119
- The current comparator therapy - page 119
- Antiplatelets - page 126
- Cyclo-oxygenase (COX) inhibitors: aspirin - page 127
- ADP antagonists - page 130
- GPIIb/IIIa inhibitors - page 135
- PGE-1 antagonists - page 136
- PI3-kinase antagonists - page 138
- PGH2/TXA2 (TP) receptor antagonists - page 138
- The current comparator therapy: Plavix (clopidogrel) - page 138
- Thrombolytics - page 154
- Plasminogen activators - page 155
- Inhibitors of plasminogen activator inhibitor-1 - page 159
- Direct clot lytics - page 159
- The current comparator therapies: alteplase and tenecteplase - page 160
- Comparison of marketed tPA-based thrombolytics - page 162
- Anticoagulants - page 104
- Clinical trial design for antithrombotics - page 163
- Phase III sample size - page 164
- Choice of control drug - page 165
- Patient exclusion - page 166
- Patient exclusion from efficacy analysis - page 167
- Duration of drug intervention - page 167
- Pre-operative or post-operative initiation of prophylaxis? - page 168
- Dosing interval - page 168
- Dose timing - page 169
- Clinical trial endpoints for antithrombotics - page 169
- Efficacy endpoints - page 169
- VTE incidence - page 170
- Diagnosis of VTE events - page 171
- Angiographic endpoints (TIMI flow grades) - page 171
- Central versus local adjudication - page 172
- Safety endpoints - page 172
- Bleeding - page 173
- Efficacy endpoints - page 169
- Classification of pipeline products - page 104
- CHAPTER 5 ANTICOAGULANTS LATE-STAGE DRUG ANALYSIS AND FORECASTS - page 175
- Overview of the key anticoagulants to be launched in long-term indications - page 176
- Pipeline summary - page 176
- Datamonitor drug assessment summary - page 177
- BAY-597939 - page 180
- Drug overview - page 180
- Preclinical data - page 180
- Clinical data - page 180
- Patient potential - page 181
- Marketing factors - page 181
- BAY-597939: performance against benchmark criteria - page 182
- SWOT analysis: BAY-597939 - page 184
- Forecast to 2015 - page 185
- Datamonitor comments - page 185
- BIBR-1048 (dabigatran etexilate) - page 186
- Drug overview - page 186
- Clinical data - page 187
- Pharmacokinetics of BIBR-1048 - page 187
- Pharmacokinetics of BIBR-953, the active form of the oral direct thrombin inhibitor BIBR-1048, in patients undergoing total hip replacement - page 187
- The effect of BIBR 953, the active form of the oral direct thrombin inhibitor BIBR-1048, on the prolongation of aPTT and ECT in orthopedic patients - page 188
- Phase II clinical trial of BIBR-1048 in MOS versus enoxaparin: BISTRO II - page 188
- Patient potential - page 189
- SPAF - greatest potential for BIBR-1048 - page 189
- Potential device competitor for SPAF indication for high-risk patients? - page 190
- Marketing factors - page 192
- BIBR-1048: performance against benchmark criteria - page 193
- SWOT analysis: BIBR-1048 - page 195
- Forecast to 2015 - page 195
- Datamonitor comments - page 196
- Idraparinux - page 197
- Drug overview - page 197
- Clinical data - page 199
- PERSIST trial - page 199
- No significant effect on liver enzymes - page 200
- Phase III VAN GOGH trial in PE patients - page 201
- Phase III AMADEUS trial - page 202
- Patient potential - page 203
- Marketing factors - page 204
- Strong presence and experience in the AF market - page 204
- High price may pose a barrier to uptake - page 205
- Lack of antidote raises concerns - page 205
- Idraparinux: performance against benchmark criteria - page 208
- SWOT analysis: Idraparinux - page 210
- Forecast to 2015 - page 210
- Datamonitor comments - page 211
- Overview of the key parenteral anticoagulants to be launched in acute indications - page 212
- Pipeline summary - page 212
- Datamonitor drug assessment summary - page 213
- ART-123 - page 215
- Drug overview - page 215
- Clinical data - page 216
- Phase I trials - page 216
- Prevention of VTE after total hip replacement - page 217
- Patient potential - page 218
- Marketing factors - page 219
- ART-123: performance against benchmark criteria - page 219
- SWOT analysis: ART-123 - page 221
- Forecast to 2015 - page 221
- Datamonitor comments - page 222
- DX-9065a - page 223
- Drug overview - page 223
- Clinical data - page 223
- XaNADU-1B trial - page 223
- XaNADU-1B results - page 224
- XaNADU-ACS trial - ongoing - page 225
- DX-9065a versus Lovenox (enoxaparin) - page 225
- Patient potential - page 226
- Marketing factors - page 228
- Low predicted cost of manufacturing - page 228
- Out-licensing opportunities in US and Europe - page 228
- DX-9065a: performance against benchmark criteria - page 228
- SWOT analysis: DX-9065a - page 230
- Forecast to 2015 - page 230
- Datamonitor comments - page 231
- Overview of the key anticoagulants to be launched in long-term indications - page 176
- CHAPTER 6 OTHER ANTICOAGULANTS - page 232
- ARC-183 - page 232
- Drug overview - page 232
- Preclinical data - page 232
- Clinical data - page 232
- AVE-5026 - page 233
- Drug overview - page 233
- AZD-0837 - page 233
- Drug overview - page 233
- AZD-9684 - page 233
- Drug overview - page 233
- BMS-562247 (apixaban) - page 234
- Drug overview - page 234
- DU-176b - page 234
- Drug overview - page 234
- Preclinical data - page 234
- EMD-593982 - page 236
- Drug overview - page 236
- KFA-1982 - page 236
- Drug overview - page 236
- LY-517717 - page 237
- Drug overview - page 237
- Preclinical data - page 237
- MCC-977 - page 237
- Drug overview - page 237
- Oral heparin and oral LMWH - page 238
- Drug overview - page 238
- rNAPc2 - page 239
- Drug overview - page 239
- Clinical data - page 240
- Treatment of ACS - page 240
- Prevention of thromboembolism - page 241
- Other indications - page 243
- SB-424323 (odiparcil) - page 243
- Drug overview - page 243
- SCH-530348 - page 243
- Drug overview - page 243
- Preclinical data - page 244
- SR-123781 - page 244
- Drug overview - page 244
- Preclinical data - page 245
- SSR-126517and SSR-182289 - page 245
- Drug overview - page 245
- Preclinical data - page 245
- TGN-167 - page 246
- Drug overview - page 246
- TGN-255 - page 246
- Drug overview - page 246
- Clinical data - page 247
- Datamonitor comments - page 248
- Tifacogin - page 248
- Drug overview - page 248
- TTP-889 - page 249
- Drug overview - page 249
- XRP-0673 (otamixaban) - page 249
- Drug overview - page 249
- Preclinical data - page 250
- Clinical data - page 250
- YM-150 - page 251
- Drug overview - page 251
- ARC-183 - page 232
- CHAPTER 7 ANTIPLATELETS LATE-STAGE DRUG ANALYSIS & FORECASTS - page 253
- Overview of the key pipeline antiplatelets forecast in this report - page 254
- Pipeline summary - page 254
- Datamonitor drug assessment summary - page 255
- Cangrelor (AR-C69931) - page 258
- Drug overview - page 258
- Preclinical data - page 259
- Clinical data - page 260
- Patient potential - page 261
- Marketing factors - page 262
- Cangrelor: performance against benchmark criteria - page 262
- SWOT analysis: Cangrelor - page 264
- Forecast to 2015 - page 264
- Datamonitor comments - page 265
- NCX-4016 - page 266
- Drug overview - page 266
- Gastrointestinal safety better than aspirin - page 266
- Endogeneous formation of carcinogenic N-nitroso compounds - page 268
- Broad range of therapeutic applications beyond aspirin - page 268
- Preclinical data - page 270
- Effects of the combination of NCX 4016, aspirin and clopidogrel in a murine model of pulmonary thromboembolism - page 270
- Clinical data - page 271
- Phase I/II trial: model of systemic inflammation in healthy patients - page 271
- Phase II clinical trial in the setting of peripheral arterial disease (PAD) - page 272
- Phase II clinical trial in type 2 diabetes patients with endothelial dysfunction - page 272
- Patient potential - page 273
- Cardiovascular disease - page 273
- Potentially limited by the phenomenon of aspirin resistance - page 273
- Marketing factors - page 274
- NCX-4016: performance against benchmark criteria - page 275
- SWOT analysis: NCX-4016 - page 276
- Forecast to 2015 - page 276
- Datamonitor comments - page 277
- Drug overview - page 266
- Prasugrel (CS-747) - page 278
- Drug overview - page 278
- Preclinical data - page 279
- Prasugrel in combination with aspirin - page 281
- Cerebral and peripheral arterial occlusive diseases - page 282
- Clinical data - page 283
- Randomized two-way cross-over, open-label study in healthy subjects - page 283
- Randomized, partially blind, parallel group dose-ranging Phase IIa study - page 284
- Patient potential - page 290
- Marketing factors - page 291
- Prasugrel: performance against benchmark criteria - page 292
- SWOT analysis: prasugrel - page 294
- Forecast to 2015 - page 294
- Datamonitor comments - page 295
- Overview of the key pipeline antiplatelets forecast in this report - page 254
- CHAPTER 8 OTHER ANTIPLATELET AGENTS - page 297
- AZD-6140 - page 297
- Drug overview - page 297
- Preclinical data - page 297
- Clinical data - page 298
- CLB-1309 - page 299
- Drug overview - page 299
- Ecraprost - page 301
- Drug overview - page 301
- Clinical data - page 301
- INS-50589 - page 301
- Drug overview - page 301
- Clinical data - page 302
- Liprostin - page 302
- Drug overview - page 302
- Clinical data - page 303
- Peripheral artery disease - page 303
- NM-702 - page 303
- Drug overview - page 303
- Clinical data - page 304
- S-18886 - page 306
- Drug overview - page 306
- Clinical data - page 306
- Preclinical data - page 307
- SL-65.0472 - page 309
- Drug overview - page 309
- Preclinical data - page 309
- Xemilofiban - page 311
- Drug overview - page 311
- GPIIb/IIIa blockade by means of oral GPIIb/IIIa blockers has a long history of failure - page 312
- The BRAVO trial - confirms excess mortality associated with oral GPIIb/IIIas - page 316
- AZD-6140 - page 297
- CHAPTER 9 THROMBOLYTICS LATE-STAGE DRUG ANALYSIS & FORECASTS - page 318
- Overview of the key pipeline thrombolytics forecast in this report - page 319
- Pipeline summary - page 319
- Datamonitor drug assessment summary - page 321
- Alfimeprase - page 325
- Drug overview - page 325
- Clinical data - page 325
- Phase I - page 325
- Phase II: peripheral arterial disease (PAD) - page 326
- Phase II: central venous catheter occlusion (CVCO) - page 327
- Phase III: peripheral arterial disease (PAD) - page 327
- Phase III: central venous catheter occlusion (CVCO) - page 327
- Patient potential - page 328
- Marketing factors - page 329
- Alfimeprase: performance against benchmark criteria - page 329
- SWOT analysis: alfimeprase - page 331
- Forecast to 2015 - page 331
- Datamonitor comments - page 332
- Amediplase - page 333
- Drug overview - page 333
- Preclinical data - page 334
- Pharmacokinetics - page 334
- Rabbit jugular vein thrombosis model - page 334
- Rabbit ear bleeding model - page 335
- Clot penetration studies - page 335
- Clinical data - page 336
- Phase I - page 336
- Phase II/III - page 337
- Patient potential - page 337
- Marketing factors - page 337
- Amediplase: performance against benchmark criteria - page 338
- SWOT analysis: amediplase - page 339
- Forecast to 2015 - page 339
- Datamonitor comments - page 340
- Desmoteplase - page 341
- Drug overview - page 341
- Preclinical data - page 341
- Pharmacokinetics - page 343
- Toxicity - page 343
- Neuroprotection - page 344
- Clinical data - page 345
- Phase I/II - page 345
- Phase II/III - page 345
- Phase II: DIAS - page 345
- Phase II: DEDAS - page 346
- Patient potential - page 348
- Marketing factors - page 348
- Desmoteplase: performance against benchmark criteria - page 350
- SWOT analysis: desmoteplase - page 351
- Forecast to 2015 - page 351
- Datamonitor comments - page 352
- Overview of the key pipeline thrombolytics forecast in this report - page 319
- CHAPTER 10 OTHER THROMBOLYTIC AGENTS - page 354
- AZD-9684 - page 354
- Drug overview - page 354
- HTU-PA (Hybrid-B PA) - page 354
- Drug overview - page 354
- Microplasmin - page 355
- Drug overview - page 355
- PAI-749 - page 356
- Drug overview - page 356
- V-10153 - page 356
- Drug overview - page 356
- Clinical data - page 356
- AZD-9684 - page 354
- APPENDIX A - page 358
- Datamonitor drug assessment summary - page 358
- Contributing experts - page 361
- Bibliography - page 362
- Epidemiology - page 362
- National hospital discharge data - page 364
- General and clinical trial data - page 365
- Datamonitor reports - page 378
- Epidemiology - page 362
- Report methodology - page 379
- About Datamonitor - page 380
- About Datamonitor Healthcare - page 380
- Datamonitor Healthcare's therapy area capabilities - page 381
- About the cardiovascular analysis team - page 381
- Disclaimer - page 383
- List of Tables
- Table 1: Developmental anticoagulants, 2005 - page 26
- Table 2: Developmental antiplatelets, 2005 - page 29
- Table 3: Developmental thrombolytics, 2005 - page 31
- Table 4: Developmental anticoagulants by drug class, 2005 - page 33
- Table 5: Developmental antiplatelets by drug class, 2005 - page 35
- Table 6: Developmental thrombolytics by drug class, 2005 - page 38
- Table 7: Developmental antithrombotics by company, 2005 - page 40
- Table 8: Key players in antithrombotic drug development, 2005 - page 43
- Table 9: Incidence of arthroplastic knee surgery (000s) - page 51
- Table 10: Incidence of arthroplastic hip surgery (000s) - page 51
- Table 11: Incidence of DVT, PE and VTE (000s) - page 55
- Table 12: Incidence of ST-segment elevation myocardial infarction (000s) - page 58
- Table 13: Incidence of unstable angina and non-ST segment elevation myocardial infarction (000s) - page 59
- Table 14: Incidence of PCIs (000s) - page 60
- Table 15: Incidence of stroke (000s) - page 62
- Table 16: Proportion of atrial fibrillation patients at risk of developing stroke - page 63
- Table 17: Prevalence of chronic atrial fibrillation (000s) - page 65
- Table 18: Prevalence of PAD in the seven major markets (000s) - page 69
- Table 19: Resistance to key oral antiplatelets - page 81
- Table 20: Proportion of stroke patients eligible for thrombolytic therapy - page 92
- Table 21: Advantages of direct thrombin inhibitors over heparin - page 109
- Table 22: OASIS-5/Michelangelo trial: efficacy - page 117
- Table 23: OASIS-5/Michelangelo trial: safety - page 117
- Table 24: Key results of CURE sub-study - page 140
- Table 25: CLARITY/TIMI-28: efficacy outcomes on angiography - page 144
- Table 26: CLARITY/TIMI-28: safety outcomes - page 145
- Table 27: COMMIT/CCS-2 trial: efficacy endpoints - page 147
- Table 28: COMMIT/CCS-2 trial: safety endpoints - page 148
- Table 29: COMMIT/CCS-2 trial: time to treatment - page 148
- Table 30: COMMIT/CCS-2 trial: thrombolytic background therapy - page 148
- Table 31: ARMYDA-2: number of events at 30 days - page 150
- Table 32: ARMYDA-2: postprocedural peak biomarker levels - page 151
- Table 33: ARMYDA-2: percentage of patients with an elevation of CKMB/troponin I - page 151
- Table 34: ARMYDA-2: number of bleeding events at 30 days - page 151
- Table 35: Comparison of tPA-based thrombolytics - page 162
- Table 36: Key efficacy endpoints used in anticoagulant clinical trials - page 170
- Table 37: Key safety endpoints used in anticoagulant clinical trials - page 172
- Table 38: Profiled key anticoagulants (long-term indications), 2005 - page 176
- Table 39: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in long-term settings - page 178
- Table 40: Global sales forecasts for BAY-597939, 2008-15 - page 185
- Table 41: Proportion of AF patients receiving antithrombotic therapy by level of risk of experiencing stroke - page 190
- Table 42: Global sales forecasts for BIBR-1048, 2008-15 - page 196
- Table 43: Comparison of fondaparinux with idraparinux - page 198
- Table 44: PERSIST trial results - page 200
- Table 45: Global sales forecasts for idraparinux, 2007-15 - page 211
- Table 46: Key parenteral anticoagulants (acute indications), 2005 - page 212
- Table 47: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in acute settings - page 213
- Table 48: Result of dose-response trial examining ART-123 - page 218
- Table 49: Global sales forecasts for ART-123, 2007-15 - page 222
- Table 50: Prothrombin F1.2 levels at baseline and after 72 hours - page 225
- Table 51: Global sales forecasts forDX-9065a, 2007-15 - page 231
- Table 52: Key pipeline antiplatelets, 2005 - page 254
- Table 53: Research, clinical and commercial attractiveness summary for key late-phase pipeline antiplatelets - page 255
- Table 54: Global sales forecasts for cangrelor, 2008-15 - page 265
- Table 55: Global sales forecasts for NCX-4016, 2008-15 - page 277
- Table 56: Comparison of antiplatelet, antithrombotic, and antihemostatic effects of prasugrel, clopidogrel and ticlopidine - page 280
- Table 57: Number of adverse events - page 285
- Table 58: JUMBO-TIMI 26: patient characteristics - page 287
- Table 59: JUMBO-TIMI 26: primary endpoint (significant bleeding) - page 287
- Table 60: JUMBO-TIMI 26: TIMI major bleeding - page 288
- Table 61: JUMBO-TIMI 26: total bleeding episodes (TIMI major/minor and minimal) - page 288
- Table 62: JUMBO-TIMI 26: secondary endpoint (MACE) - page 289
- Table 63: JUMBO-TIMI 26: MACE components - page 289
- Table 64: Global sales forecasts for prasugrel, 2008-15 - page 295
- Table 65: Results of the NM-702 Phase IIa study - page 304
- Table 66: Discontinued oral GPIIb/IIIa inhibitor pipeline - page 313
- Table 67: Summary of GPIIb/IIIa inhibitor trial failures - page 314
- Table 68: Key pipeline thrombolytics, 2005 - page 319
- Table 69: Research, clinical and commercial attractiveness summary for key pipeline thrombolytics - page 321
- Table 70: Global sales forecasts for alfimeprase, 2009-15 - page 332
- Table 71: Global sales forecasts for amediplase, 2009-15 - page 340
- Table 72: DEDAS: safety endpoints - page 347
- Table 73: Global sales forecasts for desmoteplase, 2007-15 - page 352
- Table 74: Datamonitor drug assessment parameters - page 359
- List of Figures
- Figure 1: Antithrombotics pipeline, 2005 - page 32
- Figure 2: Developmental antithrombotics by company type, 2005 - page 42
- Figure 3: Overlap of ischemic cardiovascular conditions - page 48
- Figure 4: Frequency of disease with symptoms in the three organ systems and their overlap, from the CAPRIE trial - page 49
- Figure 5: Risk of stroke increases with age - page 64
- Figure 6: Breakdown of the PAD population by classification - page 67
- Figure 7: The targets of developmental anticoagulants and selected thrombolytics - page 106
- Figure 8: Indication roll-out for Lovenox (enoxaparin) - page 121
- Figure 9: Aspirin inhibits platelet COX-1 irreversibly - page 129
- Figure 10: The role of purinergic receptors as targets for antiplatelets - page 131
- Figure 11: GP IIb/IIIa receptor antagonists act directly on the receptor - page 135
- Figure 12: CLARITY/TIMI-28: study design - page 143
- Figure 13: COMMIT/CCS-2 trial: dual antiplatelet therapy in AMI - page 147
- Figure 14: ARMYDA-2: trial design - page 150
- Figure 15: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in long-term settings - page 178
- Figure 16: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in long-term settings - page 179
- Figure 17: Performance against benchmark criteria: BAY-597939 - page 183
- Figure 18: SWOT analysis: BAY-597939 - page 184
- Figure 19: Global sales forecasts for BAY-597939, 2008-15 - page 185
- Figure 20: Performance against benchmark criteria: BIBR-1048 - page 194
- Figure 21: SWOT analysis: BIBR-1048 - page 195
- Figure 22: Global sales forecasts for BIBR-1048, 2008-15 - page 196
- Figure 23: PERSIST trial design - page 199
- Figure 24: Idraparinux Phase III program: VAN GOGH - page 202
- Figure 25: Idraparinux Phase III program: AMADEUS - page 203
- Figure 26: Is recombinant factor VIIa a valid antidote to idraparinux? - page 207
- Figure 27: Performance against benchmark criteria: idraparinux - page 209
- Figure 28: SWOT analysis: idraparinux - page 210
- Figure 29: Global sales forecasts for idraparinux, 2007-15 - page 211
- Figure 30: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in acute settings - page 214
- Figure 31: Research, clinical and commercial attractiveness summary for key anticoagulants to be launched in acute settings - page 214
- Figure 32: Performance against benchmark criteria: ART-123 - page 220
- Figure 33: SWOT analysis: ART-123 - page 221
- Figure 34: Global sales forecasts for ART-123, 2007-15 - page 222
- Figure 35: Performance against benchmark criteria: DX-9065a - page 229
- Figure 36: SWOT analysis: DX-9065a - page 230
- Figure 37: Global sales forecasts forDX-9065a, 2007-15 - page 231
- Figure 38: Research, clinical and commercial attractiveness summary for key late-phase pipeline antiplatelets - page 256
- Figure 39: Research, clinical and commercial attractiveness summary for key late-phase pipeline antiplatelets - page 257
- Figure 40: Phase II: cangrelor vs. abciximab in the setting of PCI - page 260
- Figure 41: Performance against benchmark criteria: cangrelor - page 263
- Figure 42: SWOT analysis: Cangrelor - page 264
- Figure 43: Global sales forecasts for cangrelor, 2008-15 - page 265
- Figure 44: Performance against benchmark criteria: NCX-4016 - page 275
- Figure 45: SWOT analysis: NCX-4016 - page 276
- Figure 46: Global sales forecasts for NCX-4016, 2007-15 - page 277
- Figure 47: Randomized two-way cross-over study in healthy subjects - page 283
- Figure 48: Randomized, partially blind, parallel group dose-ranging study - page 284
- Figure 49: JUMBO-TIMI 26: prasugrel in the setting of PCI - page 286
- Figure 50: TRITON-TIMI-38: trial design - page 290
- Figure 51: Performance against benchmark criteria: prasugrel - page 293
- Figure 52: SWOT analysis: prasugrel - page 294
- Figure 53: Global sales forecasts for prasugrel, 2008-15 - page 295
- Figure 54: AZD-6140 is a potent inhibitor of platelet aggregation - page 298
- Figure 55: Research, clinical and commercial attractiveness summary for key antiplatelets to be launched in acute settings - page 322
- Figure 56: Research, clinical and commercial attractiveness summary for key pipeline thrombolytics - page 323
- Figure 57: Performance against benchmarking criteria: alfimeprase - page 330
- Figure 58: SWOT analysis: alfimeprase - page 331
- Figure 59: Global sales forecasts for alfimeprase, 2009-15 - page 332
- Figure 60: Performance against benchmarking criteria: amediplase - page 338
- Figure 61: SWOT analysis: amediplase - page 339
- Figure 62: Global sales forecasts for amediplase, 2009-15 - page 340
- Figure 63: Performance against benchmark criteria: desmoteplase - page 350
- Figure 64: SWOT analysis: desmoteplase - page 351
- Figure 65: Global sales forecasts for desmoteplase, 2007-15 - page 352
- Figure 66: Example of Datamonitor drug assessment scorecard - page 360
- Figure 67: Example of Datamonitor drug assessment graph - page 361
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