Monoclonal Antibody Therapies: Evolving into a $30 billion market
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- CHAPTER 1 EXECUTIVE SUMMARY - page 4
- Scope of the report - page 4
- Key findings - page 5
- The monoclonal antibodies market is expected to almost triple in value over the next six years from $10.3 billion in 2004 to $30.3 billion, growing at a CAGR of 19.8%. Oncology products will continue to dominate the market in terms of commercial value and pipeline development. However, sales of arthritis, immune and inflammatory disorders (AIID) products are forecast to grow strongly and account for 40.1% of the market value in 2010. - page 6
- The development focus of the industry is moving away from murine and chimeric antibodies, to humanized and, in particular, fully human technologies. The market is expected to continue to evolve as antibody engineering capabilities advance further, including more efficient manufacturing and alternative delivery methods, broadening the commercial viability of antibodies treatments in a wider range of diseases. - page 8
- Roche and Genentech dominate the monoclonal market, with a combined market share of 44.9% in 2004, although this is forecast to slip to 35.7% in 2010. Datamonitor identified just 17 companies with direct sales of monoclonal antibodies in 2004, but this figure is expected to more than double to 36 in 2010, as new products and companies flood the market - page 10
- The intellectual property (IP) situation surrounding monoclonal antibodies remains complex, although resolution of patent disputes and cross-licensing agreements are starting to simplify the IP landscape. In stark contrast to small molecule drugs, antibodies currently face no prospect of generic competition. Datamonitor expects this to extend the lifecycle of antibody therapies, thereby massively increasing their profitability. - page 12
- CHAPTER 2 KEY DYNAMICS IN THE MONOCLONAL ANTIBODIES MARKET - page 30
- Introduction - page 31
- Drivers and resistors to the growth of the monoclonal antibody market - page 32
- Technology focus - evolving from murine to fully human - page 32
- Development of portfolio and pipeline - fully human antibodies to take over - page 33
- Conjugated antibodies - untapped potential - page 35
- Class of antibody - crucial to induction of effector functions - page 36
- Narrowing therapeutic focus - road to success - page 37
- Infectious and niche diseases - opportunity to expand market - page 38
- Development time - faster than conventional drugs - page 39
- Manufacturing issues - efficiency and reliability supersede under-capacity as the primary manufacturing concern - page 41
- Mammalian cell culture - disadvantages persist, but still the most widely-used system - page 42
- In-house production or out-sourcing - page 43
- Contract manufacturing - page 45
- Novel approaches - transgenic animals and plant systems - page 47
- Intellectual property - cross-licensing settlements limit legal costs and extract maximum value in the rapidly-changing IP landscape - page 50
- Patent issues - page 51
- Biosimilar antibodies - likely to rely on compulsory licensing - page 56
- Target selection - exploiting proteomics and genomics - page 57
- Technology focus - evolving from murine to fully human - page 32
- Antibody engineering evolution - page 58
- Drug delivery - improving patient convenience - page 58
- Delivery devices - page 59
- Route of administration - page 60
- Intracellular delivery of antibodies - expanding targets accessible - page 60
- Reformulation - improving the pharmacological profile - page 61
- Bispecific monoclonal antibodies - harnessing the immune system - page 62
- Recombinant polyclonal antibodies - a human-like immune response - page 63
- Symphogen - page 63
- Therapeutic Human Polyclonals - page 64
- New techniques for antibody discovery and validation - page 64
- Ribosome display - page 64
- Target-independent discovery - page 65
- Cross-species antibodies for target validation - page 66
- Hybridoma-free generation - page 66
- In silico antibody modeling and analysis - page 67
- Drug delivery - improving patient convenience - page 58
- Company strategy - page 68
- Business model evolution - biotech moves upstream - page 68
- Technology developers and providers - page 69
- Early-stage antibody drug developers - page 71
- Late-stage antibody drug developers - page 72
- Fully integrated players - page 72
- Alternative growth strategies - the impact of big pharma - page 74
- Alliance networks - page 76
- Key drivers of partnerships - creating synergies and lowering risk - page 76
- Early-stage research and development alliances - page 77
- Later-stage development alliances - page 79
- Mergers & Acquisitions - page 80
- Development and commercialization strategies - page 82
- Business model evolution - biotech moves upstream - page 68
- CHAPTER 3 MARKET ANALYSIS - page 83
- Introduction to the monoclonal antibody market - page 84
- Market evaluation, 2004-10 - page 85
- Monoclonal antibody market value, 2004 - page 85
- Technology focus of monoclonal antibody market, 2004 - page 85
- Therapeutic focus of monoclonal antibody market, 2004 - page 87
- Monoclonal antibody market potential to 2010 - page 90
- Technology focus of monoclonal antibody market, 2005-10 - page 90
- Therapeutic focus of monoclonal antibody market, 2005-10 - page 93
- Monoclonal antibody market value, 2004 - page 85
- Portfolio and pipeline analysis - page 96
- Monoclonal antibodies marketed portfolio, 2004 - page 96
- Technology focus - page 97
- Therapeutic focus - page 99
- Launch pattern of marketed monoclonal antibodies, 1986-2004 - page 100
- Monoclonal antibody pipeline - page 102
- Key late-stage pipeline monoclonal antibodies - page 102
- Forecasted launch trajectory for monoclonal antibodies, 2005-10 - page 104
- Key growth drivers, 2005-10 - page 105
- Monoclonal antibodies marketed portfolio, 2004 - page 96
- R&D development programs - page 106
- Technology focus, 2005 - page 107
- Therapeutic focus, 2005 - page 109
- CHAPTER 4 ANTIBODY ENGINEERING TECHNOLOGIES - page 111
- Introduction - page 111
- Murine - page 112
- Chimeric - page 113
- Humanized - page 114
- Fully human - page 115
- Transgenic mice - page 115
- Phage display - page 116
- Fragments - page 117
- Conjugated - page 119
- Technology profiles - Humanized Technologies - page 120
- Protein Design Labs' SMART Humanization Technology - page 120
- SMART Humanization technology - page 120
- Partnerships - page 121
- Product portfolio and pipeline - page 123
- XOMA's Human Engineering Technology - page 125
- Human Engineering - page 125
- Partnerships - page 126
- Product portfolio and pipeline - page 127
- Aeres Biomedical's Humanization Technology - page 128
- Aeres Biomedical's humanization technology - page 128
- Partnerships - page 129
- Product portfolio and pipeline - page 130
- Protein Design Labs' SMART Humanization Technology - page 120
- Technology profiles - Fully Human Technologies - page 131
- Medarex's UltiMAb Technology - page 131
- UltiMAb Human Antibody Development System - page 131
- Partnerships - page 132
- Product portfolio and pipeline - page 134
- Abgenix's XenoMouse and XenoMax - page 136
- XenoMouse and XenoMax - page 136
- Partnerships - page 138
- Product portfolio and pipeline - page 140
- Cambridge Antibody Technology's Phage Display and Ribosome Display Technologies - page 141
- Phage Display technology - page 141
- Ribosome Display technology - page 143
- Partnerships - page 143
- Product portfolio and pipeline - page 145
- Dyax's Phage Display Discovery Tool - page 147
- Phage Display Discovery Tool - page 147
- Partnerships - page 147
- Product portfolio and pipeline - page 149
- Medarex's UltiMAb Technology - page 131
- Technology profiles - Antibody Fragment Technologies - page 149
- Enzon's Single Chain Antibody Technology - page 149
- Single-Chain Antibody (SCA) technology - page 149
- Partnerships - page 151
- Product portfolio and pipeline - page 153
- Domantis' Domain Antibodies - page 154
- Domain Antibodies - page 154
- Partnerships - page 155
- Product portfolio and pipeline - page 156
- Enzon's Single Chain Antibody Technology - page 149
- Technology profiles - Conjugated Antibody Technologies - page 157
- Immunogen's Tumor-Activated Prodrug (TAP) technology - page 157
- Tumor-Activated Prodrug (TAP) Technology - page 157
- Partnerships - page 158
- Product portfolio and pipeline - page 160
- Seattle Genetics' Antibody-drug Conjugate (ADC) and Antibody-Directed Enzyme Prodrug Therapy (ADEPT) Technologies - page 161
- Antibody-drug conjugate (ADC) technology - page 161
- Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - page 162
- Overview - page 163
- Partnerships - page 163
- Product portfolio and pipeline - page 166
- Immunogen's Tumor-Activated Prodrug (TAP) technology - page 157
- CHAPTER 5 COMPANY ANALYSIS - page 168
- Key players in mAb market, 2004 - page 169
- Current position - page 169
- Benchmarking key players' future performance to 2010 - page 172
- Analysis of key players by technology focus - page 175
- Analysis of key players by therapeutic focus - page 176
- Oncology antibodies - current and future market leaders - page 177
- AIID (arthritis, immune and inflammatory disorders) antibodies - current and future market leaders - page 179
- Other therapeutic markets - niche products growing in importance - page 181
- Infectious disease - page 181
- Ophthalmology - page 182
- CNS - page 182
- Cardiovascular - page 183
- Respiratory - page 184
- Company profiles - page 184
- Abbott Laboratories - page 185
- Introduction to Abbott - page 185
- Strategy - page 186
- Growth strategy in the monoclonal antibody market - page 186
- Financial position - page 186
- SWOT analysis - page 187
- Alliance network - page 187
- Technology focus - page 189
- Monoclonal antibody portfolio and pipeline analysis - page 190
- Marketed portfolio - page 190
- R&D compounds - page 193
- Sales forecasts and forecast revenue growth - page 196
- Alexion - page 197
- Introduction to Alexion - page 197
- Strategy - page 197
- Growth strategy in the monoclonal antibody market - page 197
- Financial position - page 198
- SWOT analysis - page 199
- Alliance network - page 200
- Technology focus - page 201
- Monoclonal antibody portfolio and pipeline analysis - page 202
- Marketed portfolio - page 202
- R&D compounds - page 202
- Sales forecasts and forecast revenue growth - page 207
- Biogen Idec - page 208
- Introduction to Biogen Idec - page 208
- Strategy - page 209
- Growth strategy in the monoclonal antibody market - page 209
- Financial position - page 211
- SWOT analysis - page 212
- Alliance network - page 213
- Technology focus - page 216
- Monoclonal antibody portfolio and pipeline analysis - page 218
- Marketed portfolio - page 218
- Rituxan (rituximab) - page 219
- Zevalin (ibritumomab tiuxetan) - page 221
- Tysabri (natalizumab) - page 223
- R&D compounds - page 227
- Sales forecasts and forecast revenue growth - page 229
- Cambridge Antibody Technology - page 231
- Introduction to Cambridge Antibody Technology - page 231
- Strategy - page 232
- Growth strategy in the monoclonal antibody market - page 232
- Financial position - page 236
- SWOT analysis - page 238
- Alliance network - page 239
- Technology focus - page 244
- Monoclonal antibody portfolio and pipeline analysis - page 245
- Marketed portfolio - page 245
- R&D compounds - page 248
- Sales forecasts and forecast revenue growth - page 254
- Key licensed products - page 254
- Genentech - page 256
- Introduction to Genentech - page 257
- Strategy - page 257
- Growth strategy in the monoclonal antibody market - page 257
- Financial position - page 258
- SWOT analysis - page 258
- Strengths - page 259
- Weaknesses - page 259
- Opportunities - page 260
- Threats - page 260
- Alliance network - page 261
- Technology focus - page 263
- Monoclonal antibody portfolio and pipeline analysis - page 264
- Marketed portfolio - page 264
- Rituxan (rituximab) - page 266
- Herceptin (trastuzumab) - page 268
- Avastin (bevacizumab) - page 270
- Xolair (omalizumab) - page 272
- Raptiva (efalizumab) - page 274
- R&D compounds - page 276
- Lucentis (ranibizumab) - page 277
- Rituxan (rituximab) - page 278
- Sales forecasts and forecast revenue growth - page 278
- Genmab - page 279
- Introduction to Genmab - page 279
- Strategy - page 280
- Growth strategy in the monoclonal antibody market - page 280
- Financial position - page 282
- SWOT analysis - page 283
- Alliance network - page 284
- Technology focus - page 289
- Monoclonal antibody portfolio and pipeline analysis - page 290
- Marketed portfolio - page 290
- R&D compounds - page 290
- Sales forecasts and forecast revenue growth - page 297
- ImClone Systems - page 297
- Introduction to ImClone Systems - page 298
- Strategy - page 298
- Growth strategy in the monoclonal antibody market - page 298
- Financial position - page 300
- SWOT analysis - page 301
- Alliance network - page 302
- Technology focus - page 306
- Monoclonal antibody portfolio and pipeline analysis - page 307
- Marketed portfolio - page 307
- R&D compounds - page 315
- Sales forecasts and forecast revenue growth - page 318
- Medarex - page 319
- Introduction to Medarex - page 319
- Strategy - page 320
- Growth strategy in the monoclonal antibody market - page 320
- Financial position - page 321
- SWOT analysis - page 322
- Alliance network - page 322
- Technology focus - page 324
- Monoclonal antibody portfolio and pipeline analysis - page 326
- Marketed portfolio - page 326
- R&D compounds - page 326
- Sales forecasts and forecast revenue growth - page 333
- MedImmune - page 334
- Introduction to MedImmune - page 334
- Strategy - page 335
- Growth strategy in the monoclonal antibody market - page 335
- Financial position - page 336
- SWOT analysis - page 337
- Alliance network - page 338
- Technology focus - page 339
- Monoclonal antibody portfolio and pipeline analysis - page 340
- Marketed portfolio - page 340
- R&D compounds - page 342
- Sales forecasts and forecast revenue growth - page 345
- UCB - page 345
- Introduction to UCB - page 346
- Strategy - page 347
- Growth strategy in the monoclonal antibody market - page 347
- Financial position - page 348
- SWOT analysis - page 350
- Alliance network - page 350
- Technology focus - page 352
- Monoclonal antibody portfolio and pipeline analysis - page 354
- Marketed portfolio - page 354
- R&D compounds - page 354
- Sales forecasts and forecast revenue growth - page 357
- Key players in mAb market, 2004 - page 169
- CHAPTER 6 APPENDIX : SUPPORTING DATA - page 359
- Financial data - page 359
- Exchange rates - page 359
- Methodology for therapy area forecasting - page 360
- Financial data - page 359
- List of Tables
- Table 1: Key effector functions of antibody classes - page 36
- Table 2: Sales of monoclonal antibodies by technology, 2004 - page 85
- Table 3: Sales of monoclonal antibodies by therapy area, 2004 - page 88
- Table 4: Forecast sales of the monoclonal antibodies market by technology, 2005-10 - page 90
- Table 5: Forecast sales of the monoclonal antibodies market by therapy area in terms of sales, 2005-10 - page 93
- Table 6: Marketed monoclonal antibodies, 2004 - page 96
- Table 7: Launch year of marketed monoclonal antibody, 1986-2004 - page 100
- Table 8: Top 10 late-stage pipeline monoclonal antibodies in terms of value, 2005 - page 102
- Table 9: Launch trajectory of monoclonal antibodies in development, 2005-10 - page 104
- Table 10: Products developed using PDL's SMART Humanization technology - page 124
- Table 11: Products developed using Xoma's Human Engineering - page 127
- Table 12: Products developed using Aeres Biomedical's antibody humanization technology - page 130
- Table 13: Products developed using Medarex's UltiMAb technology - page 135
- Table 14: Products developed using Abgenix's Xenomouse and Xenomax technologies - page 140
- Table 15: Products developed using CAT's Phage Display technology - page 146
- Table 16: Products developed using Dyax's Phage Display Discovery Tool technology - page 149
- Table 17: Products developed using Enzon's SCA technology - page 154
- Table 18: Products developed using Domantis's Domain Antibodies technology - page 157
- Table 19: Products developed using ImmunoGen's TAP technology - page 160
- Table 20: Products developed using Seattle Genetics' ADC technology - page 166
- Table 21: Monoclonal antibody revenues for leading companies, 2002-04 - page 169
- Table 22: Forecast monoclonal antibody revenues for leading companies, 2004-10 - page 172
- Table 23: Leading companies' sales of monoclonal antibodies for oncology indications, 2003-10 - page 177
- Table 24: Leading companies' sales of monoclonal antibodies for AIID indications, 2003-10 - page 179
- Table 25: Leading companies' sales of monoclonal antibodies for infectious disease indications, 2003-10 - page 181
- Table 26: Leading companies' sales of monoclonal antibodies for ophthalmic indications, 2003-10 - page 182
- Table 27: Leading companies' sales of monoclonal antibodies for CNS indications, 2003-10 - page 182
- Table 28: Leading companies' sales of monoclonal antibodies for cardiovascular indications, 2003-10 - page 183
- Table 29: Leading companies' sales of monoclonal antibodies for respiratory indications, 2003-10 - page 184
- Table 30: Breakdown of Abbott's monoclonal antibody sales by therapy area, 2003-04 - page 190
- Table 31: Abbott's marketed monoclonal antibody products - page 191
- Table 32: Abbott's monoclonal antibody pipeline, 2005 - page 195
- Table 33: Forecast sales for Abbott's monoclonal antibody portfolio, 2005-10 - page 196
- Table 34: Alexion's monoclonal antibody pipeline, 2005 - page 203
- Table 35: Forecast sales for Alexion's monoclonal antibodies, 2005-10 - page 207
- Table 36: Breakdown of Biogen Idec's monoclonal antibody revenues by therapy area, 2003-04 - page 218
- Table 37: Biogen Idec's marketed monoclonal antibody products - page 219
- Table 38: Biogen Idec's monoclonal antibody pipeline, 2005 - page 228
- Table 39: Forecast revenues for Biogen Idec's monoclonal antibody portfolio, 2005-10 - page 229
- Table 40: Breakdown of CAT's monoclonal antibody sales by therapy area, 2003-04 - page 245
- Table 41: CAT's marketed monoclonal antibody products - page 245
- Table 42: CAT's monoclonal antibody pipeline, 2005 - page 249
- Table 43: Forecast revenues for CAT's monoclonal antibodies, 2004-10 - page 254
- Table 44: Genentech's collaboration focus - page 263
- Table 45: Genentech's monoclonal antibody sales by therapy area, 2003-04 - page 265
- Table 46: Genentech's marketed monoclonal antibody products - page 266
- Table 47: Genentech's monoclonal antibody pipeline, 2005 - page 276
- Table 48: Forecast sales for Genentech's monoclonal antibody portfolio, 2004-10 - page 278
- Table 49: Genmab's monoclonal antibody pipeline, 2005 - page 291
- Table 50: Forecast sales for Genmab's monoclonal antibodies, 2005-10 - page 297
- Table 51: Breakdown of ImClone's monoclonal antibody sales by therapy area, 2003-04 - page 307
- Table 52: ImClone's marketed monoclonal antibody products - page 307
- Table 53: BOND trial summary results - page 310
- Table 54: ImClone's monoclonal antibody pipeline, 2005 - page 316
- Table 55: Forecast revenues for ImClone's monoclonal antibody portfolio, 2004-10 - page 318
- Table 56: Medarex's monoclonal antibody pipeline, 2005 - page 327
- Table 57: Forecast revenues for Medarex's monoclonal antibody, 2005-10 - page 333
- Table 58: Breakdown of MedImmune's monoclonal antibody revenue by therapy area, 2003-04 - page 340
- Table 59: MedImmune's marketed monoclonal antibody products - page 341
- Table 60: MedImmune's monoclonal antibody pipeline, 2005 - page 343
- Table 61: Forecast revenues for MedImmune's monoclonal antibody portfolio, 2004-10 - page 345
- Table 62: UCB's monoclonal antibody pipeline, 2005 - page 355
- Table 63: Forecast sales for UCB's monoclonal antibody portfolio, 2004-10 - page 357
- Table 64: Exchange rates, 2004 - page 359
- List of Figures
- Figure 1: Monoclonal antibody market absolute ethical sales forecast by therapy area, 2002-10 - page 6
- Figure 2: Technological exposure of antibody development programs, 2005 - page 9
- Figure 3: By 2010, the market dominance of the leading few companies will be diluted, as increasing numbers of new products and new players enter the marketplace - page 11
- Figure 4: Launch trajectory of marketed monoclonal antibodies by technology, 1986-2010 - page 34
- Figure 5: Positioning of antibody companies by stage of development of business model - page 69
- Figure 6: Technology exposure of monoclonal antibody market, 2003-04 - page 87
- Figure 7: Therapy area exposure of monoclonal antibody market, 2003-04 - page 89
- Figure 8: Evolution in technology of the monoclonal antibody market in terms of sales, 2004-10 - page 92
- Figure 9: Evolution in therapy area of the monoclonal antibody market, 2004-10 - page 95
- Figure 10: Monoclonal antibody market technology split by sales, in comparison with the number of marketed monoclonal antibodies in 2004 - page 98
- Figure 11: Monoclonal antibody market therapy area split by sales, in comparison with the number of marketed monoclonal antibodies in 2004 - page 99
- Figure 12: Growth drivers of the monoclonal antibody market, 2005-10 - page 105
- Figure 13: Stage of development of antibody development programs, 2005 - page 106
- Figure 14: Technological exposure of antibody development programs, 2005 - page 107
- Figure 15: Therapeutic exposure of antibody development programs, 2005 - page 109
- Figure 16: The structure of an antibody - page 111
- Figure 17: Types of antibodies - page 112
- Figure 18: Schematic illustration of antibody fragments - page 118
- Figure 19: PDL's partnerships for its SMART humanization technology - page 122
- Figure 20: Xoma's partnerships for its Human Engineering technology - page 126
- Figure 21: Aeres Biomedical's partnerships for its antibody humanization technology - page 129
- Figure 22: Medarex's partnerships for its UltiMAb technology - page 133
- Figure 23: Abgenix's partnerships for its XenoMouse and XenoMax technologies - page 138
- Figure 24: CAT's partnerships for its Phage Display technology - page 144
- Figure 25: Dyax's partnerships for its Phage Display Discovery Tool technology - page 148
- Figure 26: Enzon's partnerships for its SCA technology - page 152
- Figure 27: Domantis's partnerships for its Domain Antibodies technology - page 156
- Figure 28: ImmunoGen's partnerships for its TAP technology - page 159
- Figure 29: Seattle Genetics' partnerships for its ADC and ADEPT technologies - page 164
- Figure 30: Leading companies' global market shares of antibody product sales, 2004 - page 171
- Figure 31: Leading companies' forecast global market shares of antibody product sales, 2010 - page 173
- Figure 32: Technology exposure of key antibody companies - page 175
- Figure 33: Market shares of companies involved in the oncology mAbs market, 2004-10 - page 178
- Figure 34: Market shares of companies involved in the AIID mAbs market, 2004-10 - page 180
- Figure 35: Assessment of Abbott's strategic position, 2004 - page 187
- Figure 36: Abbott's monoclonal antibody alliances - page 188
- Figure 37: Abbott's technology exposure - page 189
- Figure 38: Abbott's ethical sales breakdown, 2004 - page 191
- Figure 39: Abbott's therapeutic focus - page 194
- Figure 40: Assessment of Alexion's strategic position, 2004 - page 199
- Figure 41: Alexion's monoclonal antibody alliances - page 200
- Figure 42: Alexion's technology exposure - page 201
- Figure 43: Alexion's therapeutic focus - page 202
- Figure 44: Proportion of Biogen Idec's revenues derived from monoclonal antibodies, 2004-2010 - page 212
- Figure 45: Assessment of Biogen Idec's strategic position, 2004 - page 212
- Figure 46: Biogen Idec's monoclonal antibody alliances - page 213
- Figure 47: Technology focus of Biogen Idec's antibody portfolio and pipeline - page 216
- Figure 48: Therapeutic focus of Biogen Idec's antibody portfolio - page 227
- Figure 49: Assessment of CAT's strategic position, 2004 - page 238
- Figure 50: CAT's monoclonal antibody alliances - page 239
- Figure 51: CAT's technology exposure - page 244
- Figure 52: CAT's business development for monoclonal antibody products by therapy area - page 248
- Figure 53: Assessment of Genentech's strategic position, 2004 - page 258
- Figure 54: Genentech's monoclonal antibody alliances - page 261
- Figure 55: Genentech's technology focus, 2004 - page 263
- Figure 56: Genentech's antibody sales breakdown, 2004 - page 265
- Figure 57: Genentech's business development for monoclonal antibody products by therapy area - page 276
- Figure 58: Assessment of Genmab's strategic position, 2004 - page 283
- Figure 59: Genmab's monoclonal antibody alliances - page 284
- Figure 60: Genmab's technology focus - page 289
- Figure 61: Genmab's therapeutic focus - page 290
- Figure 62: Assessment of ImClone's strategic position, 2004 - page 301
- Figure 63: ImClone Systems' monoclonal antibody alliances - page 302
- Figure 64: ImClone's technology exposure - page 306
- Figure 65: ImClone's therapeutic focus - page 315
- Figure 66: Assessment of Medarex's strategic position, 2004 - page 322
- Figure 67: Medarex's monoclonal antibody alliances - page 323
- Figure 68: Medarex's technology exposure - page 324
- Figure 69: Medarex's therapeutic focus - page 326
- Figure 70: Assessment of MedImmune's strategic position, 2004 - page 337
- Figure 71: MedImmune's monoclonal antibody alliances - page 338
- Figure 72: MedImmune's technology exposure - page 339
- Figure 73: MedImmune's therapeutic focus - page 342
- Figure 74: UCB's monoclonal antibody exposure, 2010 - page 349
- Figure 75: Assessment of UCB's strategic position, 2004 - page 350
- Figure 76: UCB's monoclonal antibody alliances - page 350
- Figure 77: UCB's technology exposure - page 352
- Figure 78: UCB's therapeutic focus - page 354
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