Supportive Care in Oncology-Significant growth opportunities in new supportive care indications
Scope
Report Highlights
Reasons to Purchase
Table of Contents
- ABOUT DATAMONITOR HEALTHCARE - page 2
- About the Oncology pharmaceutical analysis team - page 2
- Andrew Paramore - Oncology Lead Analyst & Head of Product Development - page 2
- About the Oncology pharmaceutical analysis team - page 2
- CHAPTER 1 EXECUTIVE SUMMARY - page 3
- Objective of the analysis - page 3
- Datamonitor insight into the oncology supportive care market - page 3
- Related reports - page 5
- Upcoming reports - page 5
- CHAPTER 2 PIPELINE OVERVIEW - page 7
- Pipeline overview - page 7
- Pipeline by developmental phase and indication - page 9
- The oncology supportive care pipeline in its entirety is relatively sparse - page 9
- Pipeline split by phase - page 11
- The late-phase pipeline will flourish in the future, as early-stage agents move forward in development - page 12
- Pipeline split by indication - page 12
- Chemotherapy-induced nausea and vomiting is the most popular indication in terms of pipeline activity - page 13
- Significant unmet needs in the cancer-related mucositis market means the early-phase pipeline has increased in activity - page 13
- A greater level of activity would have been expected in the cancer-related thrombocytopenia pipeline - page 13
- Pipeline by company - page 14
- At least 67 companies are involved in the oncology supportive care pipeline - page 14
- The high involvement of smaller companies in the oncology supportive care pipeline is not surprising, given that 82% of compounds are in early-phase development - page 14
- The top three companies in terms of marketed and pipeline oncology supportive care products are Amgen, GlaxoSmithKline and Roche - page 15
- Amgen - page 15
- GlaxoSmithKline - page 16
- Roche - page 18
- At least 67 companies are involved in the oncology supportive care pipeline - page 14
- Key metrics - page 20
- Datamonitor pipeline assessment summary - page 23
- CHAPTER 3 MARKET DEFINITION AND PIPELINE DYNAMICS - page 29
- Supportive care overview - page 29
- Market definition and classification of products - page 30
- A4A - Anti-emetics and anti-nauseants - page 30
- Playing a key role in the prophylaxis and/or treatment of acute and delayed chemotherapy-induced nausea and vomiting - page 30
- Defining the emetic risk of various cytotoxics used to treat cancer - page 31
- Anti-emetic mode of action is conferred by blocking the action of various neuroreceptors - page 31
- Classes of anti-emetic/anti-nauseant - page 32
- B3C - Erythropoiesis-stimulating products - page 35
- Anemia may severely affect patient quality of life - page 35
- Products capable of stimulating the production of red blood cells can be used to treat cancer-related anemia - page 35
- Key erythropoiesis-stimulating products - page 35
- L3A1 - Colony-stimulating factors - page 36
- Neutropenia was potentially fatal before the introduction of current supportive care measures - page 36
- Colony-stimulating factors promote the production of white blood cells to prevent neutropenia - page 36
- Key colony-stimulatings factors - page 37
- L3A9 - All other immunostimulating agents excluding interferons - page 37
- Thrombocytopenia increases the risk of severe bleeding in cancer patients - page 37
- Only one formally approved agent exists for the prevention of thrombocytopenia to date - page 38
- M5B1/M5B2 - Bisphosphonate bone calcium regulators - page 38
- Bone metastases and tumor-induced hypercalcemia can cause significant morbidity in cancer patients - page 38
- Bisphosphonates are used in the prevention and/or treatment of cancer-related skeletal events due to their ability to restore normal balance to bone activity - page 39
- Key bisphosphonates approved for oncology indications - page 39
- V3D0 - Detoxifying agents for antineoplastic treatment - page 40
- Mucositis can result in significant complications, exacerbated by further cancer treatment and any therapy-related nausea and vomiting - page 40
- Use of the only growth factor approved for mucositis to date is restricted by its cost, particularly in more conservative markets - page 41
- A4A - Anti-emetics and anti-nauseants - page 30
- Current market dynamics - page 41
- A top-line view of the oncology supportive care market - page 41
- The large majority of drug classes underwent significant sales growth between 2005 and 2006 - page 41
- The oncology supportive care market by drug class - page 42
- A top-line view of the oncology supportive care market - page 41
- Epidemiology - page 45
- Epidemiology of cancer - page 45
- A continuously expanding patient base - page 45
- Increased incidence a consequence of aging populations and lifestyle modifications - page 45
- Epidemiology of supportive care indications - page 47
- Epidemiology of cancer - page 45
- CHAPTER 4 MARKETED PRODUCTS FORECAST ANALYSIS - page 49
- Country-specific assumptions and effects - page 49
- Generic pricing and erosion assumptions - page 49
- Product assumptions and effects - page 49
- A4A1 - 5-HT3 serotonin receptor antagonists - page 49
- Drug class asumptions - page 49
- Helsinn Pharma/MGI Pharma's Aloxi (palonosetron) - page 50
- Sanofi-Aventis's Anzemet (dolasetron) - page 53
- Roche/Chugai's Kytril (granisetron) - page 54
- Astellas' Nasea (ramosetron) - page 55
- Novartis's Navoban (tropisetron) - page 56
- Welfide/Japan Tobacco's Serotone (azasetron) - page 56
- Nisshin Kyorin Pharmaceuticals' Sinseron (indisetron) - page 57
- GlaxoSmithKline's Zofran (ondansetron) - page 57
- A4A9 - Other anti-emetics/anti-nauseants - page 58
- Merck & Co's Emend (aprepitant) - page 58
- B3C0 - Erythropoiesis-stimulating products - page 64
- Drug class assumptions - page 64
- Controversy affecting the drug class as a whole - page 64
- Amgen's Aranesp (darbepoetin alfa) - page 71
- Amgen Epogen/Johnson & Johnson's Procrit/Kirin's Eprex (epoetin alfa) - page 74
- Roche's NeoRecormon (epoetin beta) - page 76
- L3A1 - Colony-stimulating factors - page 78
- Chugai's Granocyte (lenograstim) - page 78
- Bayer Schering/Berlex's Leukine (sargramostim) - page 80
- Amgen's Neulasta (pegfilgrastim) - page 81
- Amgen's Neupogen (filgrastim) - page 83
- Kyowa Hakko Kogyo's Neu-Up (nartograstim) - page 85
- L3A9 - Other immunostimulating agents - page 85
- Wyeth's Neumega (oprelvekin) - page 85
- M5B1/M5B2 - Oral and injectable bisphosphonates - page 88
- Drug class assumptions - page 88
- Proctor & Gamble/Sanofi-Aventis's Actonel (risedronic acid) - page 88
- Novartis's Aredia (pamidronic acid) - page 90
- Astellas' Bisphonal (incadronic acid) - page 91
- Roche/GlaxoSmithKline's Bondronat/Boniva/Bonviva (ibandronic acid) - page 92
- Bayer Schering's Bonefos (clodronic acid) - page 96
- Novartis's Zometa (zoledronic acid) - page 97
- V3D0 - Other detoxifying agents for cancer - page 100
- Amgen's Kepivance (palifermin) - page 100
- A4A1 - 5-HT3 serotonin receptor antagonists - page 49
- Forecasts - page 102
- Forecast methodology - page 102
- Country-specific assumptions and effects - page 49
- CHAPTER 5 PIPELINE ANTI-EMETIC PRODUCTS ANALYSIS AND FORECASTS - page 103
- Pipeline overview - page 103
- Definition of current comparator - page 104
- GlaxoSmithKline's Zofran (ondansetron) - page 104
- The preferred 5-HT3 receptor antagonist in the seven major markets - page 104
- GlaxoSmithKline's Zofran (ondansetron) - page 104
- Reckitt Benckiser Healthcare/BioDelivery Sciences' Emezine (reformulated prochlorperazine maleate) - page 105
- Drug profile - page 105
- Issue of a non-approvable letter by the FDA for Emezine may not bode well for the drug's future - page 105
- Clinical trial data - page 106
- Pharmacokinetic studies indicate that Emezine's route of administration may result in a higher plasma concentration than traditional formulations - page 106
- Datamonitor comments - page 106
- BioDelivery Sciences believes Emezine to confer advantages by virtue of its formulation - page 106
- The widespread availability of generic prochlorperazine and more efficacious newer anti-emetics means that uptake of Emezine may be limited - page 107
- Drug profile - page 105
- Hana Biosciences/NovaDel Pharma's Zensana (reformulated ondansetron) - page 108
- Drug profile - page 108
- Long-term stability issues means reformulation of Zensana was necessary, however, this has delayed commercialization - page 108
- Clinical trial data - page 108
- Zensana has been proven bioequivalent to Zofran - page 108
- Surveyed members of the oncology community ranked Zensana highly in terms of potential ease of use - page 109
- Datamonitor comments - page 110
- Zensana confers administration advantages over traditionally formulated ondansetron, however, the drug's price point should be set with caution - page 110
- Drug profile - page 108
- ProStrakan's Sancuso (reformulated granisetron) - page 111
- Drug profile - page 111
- Sancuso allows for an alternative route of administration to Kytril - page 111
- Clinical trial data - page 111
- Phase III data show Sancuso to confer comparable efficacy and safety to oral Kytril - page 111
- Datamonitor comments - page 112
- Sancuso must be priced competitively in order to avoid being driven out of the market by generic versions of 5-HT3 anatagonists - page 112
- Drug profile - page 111
- AP Pharma's APF-530 (reformulated slow-release granisetron) - page 113
- Drug profile - page 113
- Slow-release formulation of granisetron should provide consisent protection against chemotherapy-induced nausea and vomiting - page 113
- Clinical trial data - page 114
- Clinical data support the use of a single injection of APF-530 adminstered 30 minutes before chemotherapy to provide continuous protection - page 114
- Datamonitor comments - page 115
- While generic versions of granisetron will see uptake, APF-530 may lose out somewhat to Sancuso due to its formulation - page 115
- Drug profile - page 113
- GlaxoSmithKline's casopitant (GW-679769) - page 115
- Drug profile - page 115
- Casopitant could become the second NK-1 antagonist to reach the market - page 115
- Clinical trial data - page 116
- Casopitant in combination with Zofran is effective in patients receiving moderately-emetogenic chemotherapy - page 116
- Varying doses of capositant are effective in preventing nausea and vomiting associated with highly-emetogenic chemotherapy - page 118
- Datamonitor comments - page 120
- Given the youth of the NK-1 antagonist drug class, casopitant could represent a valuable addition to treatment options - page 120
- Drug profile - page 115
- Forecasts - page 122
- Datamonitor drug assessment summary - page 124
- Future potential of pipeline anti-emetic products - page 125
- The pipeline anti-emetics will enjoy reasonable uptake and sales, however, no major breakthroughs in the prevention and/or treatment of chemotherapy-induced nausea and vomiting will be provided - page 125
- Future potential of pipeline anti-emetic products - page 125
- CHAPTER 6 PIPELINE ERYTHROPOIESIS-STIMULATING PRODUCTS ANALYSIS AND FORECASTS - page 126
- Pipeline overview - page 126
- Definition of current comparator - page 127
- Amgen's Aranesp (darbepoetin alfa) - page 127
- Available across most of the seven major markets and a more convenient dosing schedule for patients - page 127
- Amgen's Aranesp (darbepoetin alfa) - page 127
- Shire's Dynepo (epoetin delta) - page 127
- Drug profile - page 127
- The first recombinant erythropoietin to be produced in human cells - page 127
- Clinical trial data - page 128
- A complete dearth of information relating to Dynepo's development in cancer-related anemia... - page 128
- ...however, equal efficacy to Epogen/Procrit has been demonstrated in treatment of anemia related to chronic kidney disease - page 128
- Datamonitor comments - page 129
- Ongoing patent litigation with Amgen resulted in delayed European launch of Dynepo, plus a ban on US launch until relevant patents have expired - page 129
- Dynepo's pricing at a 30% discount to its competitors in Germany means that some off-label use in oncology indications is likely - page 129
- Drug profile - page 127
- Roche's Mircera (continuous erythropoietin receptor activator) - page 130
- Drug profile - page 130
- A novel erythropoiesis-stimulating agent with several theoretical advantages over competitors - page 130
- Suspension of recruitment into an oncology Phase II due to an imbalance in fatalities across treatment arms - page 131
- Clinical trial data - page 132
- Mircera appears to have dose-dependent clinical activity in anemic NHL patients receiving chemotherapy - page 132
- Phase II results in NSCLC patients support the feasibility of extended administration of Mircera - page 133
- Mircera produces a rapid and sustained hemoglobin response in multiple myeloma patients - page 134
- Datamonitor comments - page 134
- Despite potentially negative publicity surrounding suspension of enrollment into the NH19960 study, Mircera's reputation should remain relatively intact - page 134
- Hurdles put in place by Amgen need to be overcome - page 135
- Entering the EU market is likely to be slightly easier for Roche - page 135
- The entire erythropoietin drug class has come under fire - page 136
- Drug profile - page 130
- Forecasts - page 137
- Datamonitor drug assessment summary - page 138
- Future potential of pipeline erythropoeisis-stimulating products - page 139
- Both pipeline erythropoietins are expected to see some off-label use prior to formal approval in oncology indications - page 139
- Future potential of pipeline erythropoeisis-stimulating products - page 139
- CHAPTER 7 PIPELINE ANTI-NEUTROPENIA PRODUCTS ANALYSIS AND FORECASTS - page 141
- Pipeline overview - page 141
- The current cancer-related neutropenia pipeline - page 141
- An exceedingly sparse pipeline means any threat to currently marketed products is minimal - page 141
- The current cancer-related neutropenia pipeline - page 141
- Pipeline overview - page 141
- CHAPTER 8 PIPELINE ANTI-THROMBOCYTOPENIA PRODUCTS ANALYSIS AND FORECASTS - page 142
- Pipeline overview - page 142
- Definition of current comparator - page 143
- Wyeth's Neumega (oprelvekin) - page 143
- Chosen only due to the complete lack of other commercially approved products in this indication - page 143
- Wyeth's Neumega (oprelvekin) - page 143
- GlaxoSmithKline/Ligand Pharmaceuticals' Promacta (eltrombopag) - page 143
- Drug profile - page 143
- Promacta's oral availability may represent a significant advantage - page 143
- Clinical trial data - page 144
- Early trial data demonstrates Promacta's ability to boost platelet levels in cancer patients undergoing chemotherapy, but fails to meet primary endpoint - page 144
- Positive Phase III data in other indications mean that theoretically, Promacta should confer efficacy in cancer-related thrombocytopenia - page 144
- Datamonitor comments - page 145
- A severe lack of approved agents for the prevention and/or treatment of cancer-related thrombocytopenia provides opportunity - page 145
- A gap in the market exists for a product such as Promacta, which GlaxoSmithKline should take full advantage of - page 146
- Drug profile - page 143
- Amgen's AMG-531 - page 146
- Drug profile - page 146
- A novel drug designed to specifically target the thrombopoietin receptor - page 146
- Clinical trial data - page 147
- No cancer-specific study data exist, making it difficult to judge AMG-531's potential in this patient population - page 147
- Datamonitor comments - page 148
- Amgen's leading status in the oncology supportive care market will prove invaluable for AMG-531 - page 148
- Drug profile - page 146
- Forecasts - page 149
- Datamonitor drug assessment summary - page 150
- Future potential of pipeline anti-thrombocytopenia products - page 151
- Following initial off-label use in oncology indications, the anti-thrombocytopenia pipeline products are forecast to enjoy significant sales - page 151
- Future potential of pipeline anti-thrombocytopenia products - page 151
- CHAPTER 9 PIPELINE ANTI-MUCOSITIS PRODUCTS ANALYSIS AND FORECASTS - page 153
- Pipeline overview - page 153
- Definition of current comparator - page 154
- Amgen's Kepivance (palifermin) - page 154
- Chosen only due to the complete lack of other commercially approved products in this indication - page 154
- Amgen's Kepivance (palifermin) - page 154
- MGI Pharma's Saforis (L-glutamine) - page 154
- Drug profile - page 154
- Increasing availability of L-glutamine in the oral mucosa may prevent the onset of mucositis - page 154
- Clinical trial data - page 155
- Phase III trial results showing Saforis is capable of significantly reducing the incidence of oral mucositis forms the basis for NDA submission - page 155
- Earlier Phase III results show Saforis appears to reduce the incidence of oral mucositis - page 156
- Datamonitor comments - page 156
- Cost and route of administration of Amgen's Kepivance places Saforis at a significant advantage - page 156
- Drug profile - page 154
- Forecasts - page 157
- Datamonitor drug assessment summary - page 158
- Future potential of pipeline anti-mucositis products - page 159
- A relatively low level of peak sales are deceptive in the face of reasonable uptake of Saforis in cancer-releated mucositis - page 159
- Future potential of pipeline anti-mucositis products - page 159
- CHAPTER 10 PIPELINE CANCER-RELATED SKELETAL EVENTS PRODUCTS ANALYSIS AND FORECASTS - page 161
- Pipeline overview - page 161
- Definition of current comparator - page 162
- Novartis's Zometa (zoledronate) - page 162
- The leading bisphosphonate for the prevention and/or treatment of cancer-related skeletal events - page 162
- Novartis's Zometa (zoledronate) - page 162
- Amgen's denosumab (AMG-162) - page 162
- Drug profile - page 162
- The first targeted therapy for cancer-related skeletal events - page 162
- Clinical trial data - page 164
- Interim results show denosumab to be at least as effective as intravenous bisphosphonates in reducing the risk of cancer-related skeletal events - page 164
- Interim results show denosumab normalizes bone turnover more frequently than intravenous bisphosphonates - page 165
- Datamonitor comments - page 166
- By virtue of its monoclonal antibody formulation, denosumab is likely to be more expensive than currently marketed bisphosphonates... - page 166
- ...however, its lack of association with osteonecrosis of the jaw may work in its favor - page 166
- Amgen's experience represents a major advantage for denosumab - page 167
- Drug profile - page 162
- Forecasts - page 167
- Datamonitor drug assessment summary - page 168
- Future potential of pipeline cancer-related skeletal events products - page 169
- Denosumab theoretically confers several advantages over currently available bisphosphonates, therefore uptake and accompanying sales are forecast to be encouraging - page 169
- Future potential of pipeline cancer-related skeletal events products - page 169
- CHAPTER 11 COMMERCIAL IMPACT AND LIFECYCLE MANAGEMENT: CASE STUDY - page 171
- The changing oncology supportive care market - page 171
- Current areas of commercial opportunity - page 171
- Several areas of supportive care are drastically underserved at present - page 171
- Potentially increasing range of use for current products - page 172
- Increasing use of targeted therapies - page 173
- A shift towards increased use of molecular targeted therapies will introduce new supportive care challenges - page 173
- New supportive care measures need to be developed, thereby providing significant commercial opportunity... - page 174
- ...yet, it could be that the high cost of the targeted therapies will result in hampered uptake of supportive care products - page 175
- The threat of biosimilars - page 176
- The biologic supportive care products will no longer be protected from generic competition - page 176
- Some biosimilar products can be launched in the EU immediately... - page 176
- ...however, the US is lagging behind - page 176
- The high cost of some supportive care products inhibits their use, indicating a great desire for cheaper biosimilar versions... - page 177
- ...although biosimilar drugs bring with them a new set of issues - page 177
- Increased safety concerns in future - page 177
- As seen with the erythropoeitins class, increased vigilance with respect to safety may be enforced in the future - page 177
- How the oncology supportive care market will change - page 178
- On the whole, the oncology supportive care market will undergo positive growth... - page 178
- ...albeit at a minimal growth rate, due to a lack of major innovation - page 179
- Future growth is likely to come from those early-phase products targeting new supportive care indications - page 180
- Current areas of commercial opportunity - page 171
- The changing oncology supportive care market - page 171
- APPENDIX A - MARKET DATA AND MAJOR BRAND KEY FACTS - page 181
- A4A (anti-emetics and anti-nauseants) class market data - page 181
- B3C (erythropoiesis-stimulating products) class market data - page 184
- L3A1 (colony-stimulating factors) class market data - page 186
- L3A9 (other immunostimulating agents) class market data - page 188
- M5B1/M5B2 (oral and injectable bisphosphonates) class market data - page 189
- V3D0 (other detoxifying agents for cancer) class market data - page 191
- Sales data and forecasts - page 191
- PowerPoint Executive Presentation - page 192
- APPENDIX B - SALES FORECASTS - page 193
- US forecasts - page 193
- Japan forecasts - page 196
- France forecasts - page 199
- Germany forecasts - page 202
- Italy forecasts - page 205
- Spain forecasts - page 208
- UK forecasts - page 211
- Five major European markets (EU5) forecasts - page 214
- Seven major market forecasts - page 217
- APPENDIX C - page 221
- Bibliography - page 221
- List of tables - page 233
- List of figures - page 234
- Methodology - page 235
- Datamonitor forecast methodology - page 235
- Forecasts for marketed drugs - page 235
- Forecasts for pipeline drugs - page 236
- Datamonitor drug assessment methodology - page 237
- Datamonitor forecast methodology - page 235
- About Datamonitor - page 239
- About Datamonitor Healthcare - page 239
- About the Oncology analysis team - page 240
- Disclaimer - page 241
- List of Tables
- Table 1: Late-phase oncology supportive care pipeline, 2007 - page 7
- Table 2: Phase II oncology supportive care pipeline, 2007 - page 8
- Table 3: Phase I oncology supportive care pipeline, 2007 - page 9
- Table 4: Supportive care pipeline split by phase and indication, 2007 - page 10
- Table 5: Amgen's marketed oncology supportive care portfolio, 2007 - page 15
- Table 6: Amgen's pipeline oncology supportive care portfolio, 2007 - page 16
- Table 7: GlaxoSmithKline's marketed oncology supportive care portfolio, 2007 - page 17
- Table 8: GlaxoSmithKline's pipeline oncology supportive care portfolio, 2007 - page 18
- Table 9: Roche's marketed oncology supportive care portfolio, 2007 - page 19
- Table 10: Roche's pipeline oncology supportive care portfolio, 2007 - page 19
- Table 11: Late-phase pipeline oncology supportive care products sales forecasts ($m), 2007-16 - page 20
- Table 12: Marketed 5-HT3 receptor antagonists, 2007 - page 33
- Table 13: Marketed erythropoiesis-stimulating products, 2007 - page 35
- Table 14: Marketed colony-stimulating factors, 2007 - page 37
- Table 15: Marketed bisphosphonates approved for oncology indications, 2007 - page 40
- Table 16: Seven major market sales of marketed supportive care products by drug class, 2006 - page 42
- Table 17: Key anti-emetics in the oncology supportive care market across the seven major markets, 2007 - page 43
- Table 18: Key erythropoiesis-stimulating products in the oncology supportive care market across the seven major markets, 2007 - page 43
- Table 19: Key colony-stimulating factors in the oncology supportive care market across the seven major markets, 2007 - page 44
- Table 20: Key bisphosphonates in the oncology supportive care market across the seven major markets, 2007 - page 44
- Table 21: Other key products in the oncology supportive care market across the seven major markets, 2007 - page 45
- Table 22: Crude incidence rates of cancer by gender per 100,000 in the seven major pharmaceutical markets, 2002 - page 46
- Table 23: Forecast incidence of cancer across the seven major markets, 2001-15 - page 46
- Table 24: Proportion of patients receiving anti-emetics for chemotherapy-induced nausea and vomiting, 2006 - page 47
- Table 25: Proportion of patients receiving bisphosphonates for cancer-related skeletal events, 2006 - page 48
- Table 26: Generic pricing and erosion assumptions, 2007 - page 49
- Table 27: Aloxi versus Zofran: response rates from a Phase III trial to prevent CINV from moderately-emetogenic chemotherapy - page 51
- Table 28: Aloxi versus Zofran: response rates from a Phase III trial to prevent CINV from highly-emetogenic chemotherapy - page 51
- Table 29: Emend in a Phase III trial to prevent CINV from moderately-emetogenic chemotherapy - page 60
- Table 30: Emend in a Phase III trial to prevent CINV from highly-emetogenic chemotherapy - page 60
- Table 31: Fosaprepitant and Emend in a Phase III trial to prevent chemotherapy-induced nausea and vomiting from highly-emetogenic chemotherapy - page 62
- Table 32: Relative potencies of the commercially available bisphosphonates - page 88
- Table 33: Ongoing development for Actonel in oncology indications, 2007 - page 89
- Table 34: Approval information for Bondronat/Bonviva/Boniva - page 93
- Table 35: Ongoing clinical development for Bondronat, 2007 - page 93
- Table 36: Average physician preference for use of Bondronat in oncology indications across the seven major markets, 2006 - page 94
- Table 37: Ongoing Phase III clinical development for Zometa, 2007 - page 99
- Table 38: Ongoing clinical development for Kepivance, 2007 - page 101
- Table 39: Late-phase anti-emetics for chemotherapy-induced nausea and vomiting pipeline, 2007 - page 103
- Table 40: Phase I/II anti-emetics for chemotherapy-induced nausea and vomiting pipeline, 2007 - page 104
- Table 41: Results from the Phase II study investigating three different doses of APF-530 - page 114
- Table 42: Clinical trials investigating casopitant in chemotherapy-induced nausea and vomiting, 2007 - page 116
- Table 43: Treatment arms in a Phase II study investigating casopitant in the prevention of nausea and vomiting from moderately-emetogenic chemotherapy - page 117
- Table 44: Results from a Phase II study investigating casopitant in the prevention of nausea and vomiting from moderately-emetogenic chemotherapy - page 118
- Table 45: Treatment arms in a Phase II study investigating casopitant in the prevention of nausea and vomiting from highly-emetogenic chemotherapy - page 119
- Table 46: Results from a Phase II study investigating casopitant in the prevention of nausea and vomiting from highly-emetogenic chemotherapy - page 120
- Table 47: Pipeline anti-emetic products forecasting assumptions (1 of 2) - page 122
- Table 48: Pipeline anti-emetic products forecasting assumptions (2 of 2) - page 122
- Table 49: Pipeline anti-emetic products sales forecasts ($m), 2007-16 - page 123
- Table 50: Erythropoiesis-stimulating products pipeline, 2007 - page 126
- Table 51: Results from the BA16728 Phase II study investigating varying doses of Mircera in NHL patients - page 132
- Table 52: Results from the NA17101 Phase II study investigating varying doses of Mircera in NSCLC patients - page 133
- Table 53: Pipeline erythropoiesis-stimulating agents forecasting assumptions - page 137
- Table 54: Pipeline erythropoiesis-stimulating agents sales forecasts ($m), 2007-16 - page 137
- Table 55: Anti-neutropenia products pipeline, 2007 - page 141
- Table 56: Anti-thrombocytopenia products pipeline, 2007 - page 142
- Table 57: Clinical trials investigating AMG-531 in cancer-related thrombocytopenia, 2007 - page 147
- Table 58: Pipeline anti-thrombocytopenia products forecasting assumptions - page 149
- Table 59: Pipeline anti-thrombocytopenia products sales forecasts ($m), 2007-16 - page 149
- Table 60: Anti-mucositis products pipeline, 2007 - page 153
- Table 61: Results from a Phase III study investigating Saforis in breast cancer patients - page 155
- Table 62: Results from a Phase III study investigating Saforis in cancer patients - page 156
- Table 63: Pipeline anti-mucositis products forecasting assumptions - page 157
- Table 64: Pipeline anti-mucositis products sales forecasts ($m), 2007-16 - page 158
- Table 65: Cancer-related skeletal events products pipeline, 2007 - page 161
- Table 66: Phase III clinical trials investigating denosumab in oncology, 2007 - page 163
- Table 67: Phase II clinical trials investigating denosumab in oncology, 2007 - page 163
- Table 68: Interim results from study investigating denosumab in bisphosphonate-naïve metastatic breast cancer patients - page 164
- Table 69: Interim results from study investigating denosumab in advanced cancer patients who had received prior bisphosphonate therapy, 2006 - page 165
- Table 70: Pipeline cancer-related skeletal events products forecasting assumptions - page 167
- Table 71: Pipeline cancer-related skeletal events products sales forecasts ($m), 2007-16 - page 168
- Table 72: Products in development for currently unmet supportive care challenges, 2007 - page 172
- Table 73: Common side effects associated with the molecular targeted therapies - page 174
- Table 74: Products in development for new supportive care challenges, 2007 - page 175
- Table 75: Oncology supportive care market forecast sales, 2006-16 - page 178
- Table 76: Aloxi: key facts - page 181
- Table 77: Anzemet: key facts - page 181
- Table 78: Emend: key facts - page 182
- Table 79: Kytril: key facts - page 182
- Table 80: Nasea: key facts - page 182
- Table 81: Navoban: key facts - page 183
- Table 82: Serotone: key facts - page 183
- Table 83: Sinseron: key facts - page 183
- Table 84: Zofran: key facts - page 184
- Table 85: Aranesp: key facts - page 184
- Table 86: Epogen/Procrit: key facts - page 185
- Table 87: NeoRecormon: key facts - page 185
- Table 88: Granocyte: key facts - page 186
- Table 89: Leukine: key facts - page 186
- Table 90: Neulasta: key facts - page 187
- Table 91: Neupogen: key facts - page 187
- Table 92: Neu-Up: key facts - page 188
- Table 93: Neumega: key facts - page 188
- Table 94: Actonel: key facts - page 189
- Table 95: Aredia: key facts - page 189
- Table 96: Bisphonal: key facts - page 190
- Table 97: Bondronat: key facts - page 190
- Table 98: Bonefos: key facts - page 190
- Table 99: Zometa: key facts - page 191
- Table 100: Kepivance: key facts - page 191
- Table 101: Marketed supportive care product forecasts in the US, 2006-16 (1 of 3) - page 193
- Table 102: Marketed supportive care product forecasts in the US, 2006-16 (2 of 3) - page 194
- Table 103: Marketed supportive care product forecasts in the US, 2006-16 (3 of 3) - page 195
- Table 104: Marketed supportive care product forecasts in Japan, 2006-16 (1 of 3) - page 196
- Table 105: Marketed supportive care product forecasts in Japan, 2006-16 (2 of 3) - page 197
- Table 106: Marketed supportive care product forecasts in Japan, 2006-16 (3 of 3) - page 198
- Table 107: Marketed supportive care product forecasts in France, 2006-16 (1 of 3) - page 199
- Table 108: Marketed supportive care product forecasts in France, 2006-16 (2 of 3) - page 200
- Table 109: Marketed supportive care product forecasts in France, 2006-16 (3 of 3) - page 201
- Table 110: Marketed supportive care product forecasts in Germany, 2006-16 (1 of 3) - page 202
- Table 111: Marketed supportive care product forecasts in Germany, 2006-16 (2 of 3) - page 203
- Table 112: Marketed supportive care product forecasts in Germany, 2006-16 (3 of 3) - page 204
- Table 113: Marketed supportive care product forecasts in Italy, 2006-16 (1 of 3) - page 205
- Table 114: Marketed supportive care product forecasts in Italy, 2006-16 (2 of 3) - page 206
- Table 115: Marketed supportive care product forecasts in Italy, 2006-16 (3 of 3) - page 207
- Table 116: Marketed supportive care product forecasts in Spain, 2006-16 (1 of 3) - page 208
- Table 117: Marketed supportive care product forecasts in Spain, 2006-16 (2 of 3) - page 209
- Table 118: Marketed supportive care product forecasts in Spain, 2006-16 (3 of 3) - page 210
- Table 119: Marketed supportive care product forecasts in the UK, 2006-16 (1 of 3) - page 211
- Table 120: Marketed supportive care product forecasts in the UK, 2006-16 (2 of 3) - page 212
- Table 121: Marketed supportive care product forecasts in the UK, 2006-16 (3 of 3) - page 213
- Table 122: Marketed supportive care product forecasts in the EU5, 2006-16 (1 of 3) - page 214
- Table 123: Marketed supportive care product forecasts in the EU5, 2006-16 (2 of 3) - page 215
- Table 124: Marketed supportive care product forecasts in the EU5, 2006-16 (3 of 3) - page 216
- Table 125: Marketed supportive care product forecasts across the seven major markets, 2006-16 (1 of 4) - page 217
- Table 126: Marketed supportive care product forecasts across the seven major markets, 2006-16 (2 of 4) - page 218
- Table 127: Marketed supportive care product forecasts across the seven major markets, 2006-16 (3 of 4) - page 219
- Table 128: Marketed supportive care product forecasts across the seven major markets, 2006-16 (4 of 4) - page 220
- Table 129: Datamonitor drug assessment parameters - page 237
- List of Figures
- Figure 1: Supportive care pipeline split by phase and indication, 2007 - page 10
- Figure 2: Supportive care pipeline split by phase, 2007 - page 11
- Figure 3: Supportive care pipeline split by indication, 2007 - page 12
- Figure 4: Supportive care pipeline split by company, 2007 - page 14
- Figure 5: Pipeline anti-emetic products sales forecasts in the oncology supportive care market ($m), 2007-16 - page 21
- Figure 6: Pipeline erythropoiesis-stimulating agents sales forecasts in the oncology supportive care market ($m), 2007-16 - page 21
- Figure 7: Pipeline anti-thrombocytopenia products sales forecasts in the oncology supportive care market ($m), 2007-16 - page 22
- Figure 8: Pipeline anti-mucositis products sales forecasts in the oncology supportive care market ($m), 2007-16 - page 22
- Figure 9: Pipeline cancer-related skeletal events products sales forecasts in the oncology supportive care market ($m), 2007-16 - page 23
- Figure 10: Datamonitor drug assessment summary for the pipeline anti-emetics in the oncology supportive care market, 2007 - page 24
- Figure 11: Datamonitor drug assessment summary for the pipeline erythropoiesis-stimulating products in the oncology supportive care market, 2007 - page 25
- Figure 12: Datamonitor drug assessment summary for the pipeline anti-thrombocytopenia products in the oncology supportive care market, 2007 - page 26
- Figure 13: Datamonitor drug assessment summary for the pipeline anti-mucositis products in the oncology supportive care market, 2007 - page 27
- Figure 14: Datamonitor drug assessment summary for the pipeline cancer-related skeletal events products in the oncology supportive care market, 2007 - page 28
- Figure 15: Forecast incidence of cancer across the seven major markets, 2001-15 - page 47
- Figure 16: Pipeline anti-emetic products sales forecasts ($m), 2007-16 - page 123
- Figure 17: Datamonitor drug assessment summary for the pipeline anti-emetics, 2007 - page 124
- Figure 18: Pipeline erythropoiesis-stimulating agents sales forecasts ($m), 2007-16 - page 138
- Figure 19: Datamonitor drug assessment summary for the pipeline erythropoiesis-stimulating products, 2007 - page 139
- Figure 20: Pipeline anti-thrombocytopenia products sales forecasts ($m), 2007-16 - page 150
- Figure 21: Datamonitor drug assessment summary for the pipeline anti-thrombocytopenia products, 2007 - page 151
- Figure 22: Pipeline anti-mucositis products sales forecasts ($m), 2007-16 - page 158
- Figure 23: Datamonitor drug assessment summary for the pipeline anti-mucositis products, 2007 - page 159
- Figure 24: Pipeline cancer-related skeletal events products sales forecasts ($m), 2007-16 - page 168
- Figure 25: Datamonitor drug assessment summary for the pipeline cancer-related skeletal events products, 2007 - page 169
- Figure 26: Oncology supportive care market forecast sales, 2006-16 - page 179
- Figure 27: Datamonitor drug assessment summary for the pipeline cancer-related skeletal events products, 2007 - page 238
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