Gene Expression Profiling Markets
Parts of the gene expression analysis market continue to develop in a somewhat predictable manner, whereas other segments are becoming increasingly complex and volatile. The main products—microarrays and RT-PCR—continue to gain widespread acceptance and to see revenues grow rapidly. However, different products and applications are increasingly being introduced, making the market more fragmented as well as unpredictable. In terms of application, too, the landscape is shifting. Although life-science research is still the dominant application, the clinical diagnostics and prognostics market is also becoming a reality.
This new study on the gene expression analysis market reviews the major technologies being employed, including:
- Alternative Splicing; Splice Variant Microarrays
- Cap Analysis of Gene Expression (CAGE)
- Comparative Genomic Hybridization (CGH)
- ChIP-on-chip
- DNA Microarrays
- Gene Trapping
- Methylation, Other Epigenetic Analysis
- MicroRNA
- Real-time PCR (RT-PCR)
- RNAse Protection Assays
- Serial Analysis of Gene Expression (SAGE)
- Tissue Arrays / Microarrays
- Transcript Analysis with Affinity Capture (TRAC)
In addition to comprehensive review of the products on the market from the major suppliers, each of the main applications of gene expression technologies is also reviewed, including:
- Biomarkers,
- Pharmacogenetics / Pharmacogenomics,
- Infectious Disease Research,
- Cancer Diagnostics and Prognostics, and
- Diagnosis and Prognosis of Other Diseases
The report provides a complete analysis of the market, including historical data on the market for RT-PCR and microarrays, instruments, and reagents. The report also forecasts revenues through 2012 in the segment and provides growth rates for each of the coming years, a complete regional breakdown of revenues, and revenue detail on the dominant player by region. A thorough competitive analysis includes revenue and market share of the top vendors. Detailed profiles of the following competitors are also included:
- Affymetrix
- Agilent Technologies
- Applied Biosystems
- Beckman Coulter
- Combimatrix
- Illumina
- Roche Applied Science
Gene Expression Profiling Markets also details the business, regulatory, academic, and research trends in the market, providing comprehensive information on consortia, standardization efforts, and scores of recent deals in the sector.
Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
- Introduction and Summary
- Background and Definitions
- Alternative Splicing; Splice Variant Microarrays
- Cap Analysis of Gene Expression (CAGE)
- Comparative Genomic Hybridization (CGH)
- ChIP-on-chip
- DNA Microarrays
- Gene Trapping
- Methylation, Other Epigenetic Analysis
- MicroRNA
- Real-time PCR (RT-PCR)
- RNAse Protection Assays
- Serial Analysis of Gene Expression (SAGE)
- Tissue Arrays / Microarrays
- Transcript Analysis with Affinity Capture (TRAC)
CHAPTER TWO: APPLICATIONS
- Biomarkers
- Pharmacogenetics / Pharmacogenomics
- Cancer Diagnosis, Prognosis, Sub-Classification
- Breast Cancer
- Esophageal Cancer
- Head and Neck Cancer
- Kidney Cancer
- Leukemia
- Lung Cancer
- Lymphoma
- Oral Cancer
- Ovarian Cancer
- Prostate Cancer
- Pancreatic Cancer
- Multiple, General
- Infectious Disease Research
- Diagnostic / Prognostic Technologies and Applications
- Agendia
- MammaPrint
- DakoCytomation
- Hercep-Test
- ChondroGene
- Sentinel Technology
- Genomic Health
- Oncotype DX
- Gleevec, Sprycel
- Velcade
- Agendia
CHAPTER THREE: INDUSTRY, TECHNOLOGY, AND REGULATORY TRENDS
- Industry Trends
- Gene Expression Profiling Becoming Established Tool
- Various Types of Small RNA Gaining Importance
- Gene Expression Analysis Moves Gradually into Diagnostics
- Quality Control of RNA Samples Becoming Standard Process
- Technology Trends
- New Technologies Entering Gene Expression Analysis Market
- Questions Remain Regarding Housekeeping and Reference Genes
- Probe Length Still Varying Greatly Between Vendors
- Amplification Remains Key Aspect of Experiments
- Sample Preparation Becoming High Priority
- Regulatory Trends
- March 2004 - Critical Path Initiative
- March 2005 - “Guidance for Industry - Pharmacogenomic Data Submissions”
- April 2005 - “Drug-Diagnostic Co-Development Concept Paper”
- March 2006 - Critical Path Opportunities List
- November 2006 - “Recommendations for the Generation and Submission of Genomic Data”
- August 2007 - “Pharmacogenomic Data Submissions — Companion Guidance”
CHAPTER FOUR: PRODUCTS AND SERVICES FOR RESEARCH APPLICATIONS
- Research Products
- Affymetrix
- Overview
- Hardware
- Microarrays
- Agilent Technologies
- Overview
- Hardware
- Microarrays
- Applied Biosystems
- Expression Array System
- TaqMan Gene Expression Assays
- Ambion (an Applied Biosystems Business)
- mirVana miRNA Bioarrays
- Beckman Coulter
- GenomeLab GeXP Genetic Analysis System
- GenomeLab GeXP Rat MultitoxPlex Panel
- Biomek 3000-ArrayPLEX
- Bio-Rad
- Aurum Total RNA Kits
- BioOdyssey Calligrapher MiniArrayer
- VersArray ChipWriter Pro
- Experion Automated Electrophoresis System
- Experion Automated Electrophoresis System
- Experion Priming Station, Experion Vortex Station
- Biosearch Technologies
- CAL Fluor Dyes, Quasar Dyes, Black Hole Quencher Dyes
- Combimatrix
- Overview
- CustomArray Synthesizer
- Epicentre Biotechnologies
- ArrayPure Nano-scale RNA Purification Kit
- MessageBOOSTER cDNA Synthesis Kit for qPCR
- TargetAmp aRNA Amplification Kits
- Exiqon
- febit
- Geniom One
- Illumina
- DASL AssayFocused ArraysGenome-Wide Expression BeadChips
- Kreatech Biotechnology
- miRACULS miRNA Kit
- Marligen Biotechnologies
- Multiplex Transcription Factor Assays
- Panomics
- QuantiGene 2.0 Reagent System
- Roche Applied Science
- LightCycler 480 System
- Stratagene (Agilent)
- Stratagene
- SideStep and SideStep II Products and Kits
- Affymetrix
- Products - Selected List
- Next-Generation Sequencers
- Diagnostic, Prognostic, Theranostic Products
- Software and Services
- Althea Technologies
- Inflammation:
- Cancer:
- Tox and Specialty:
- Gene Logic [Ocimum]
- Genomatix Software GmbH
- ChipInspector
- BiblioSphere Pathway Edition
- Iconix Biosciences
- DrugMatrix
- Althea Technologies
CHAPTER FIVE: CONSORTIA, INITIATIVES, STANDARDIZATION, DEALS
- Critical Path Institute
- External RNA Controls Consortium (ERCC)
- MicroArray Quality Control (MAQC) Project
- Minimum Information About a Microarray Experiment (MIAME)
- NIH Roadmap for Medical Research
- Institutional Clinical and Translational Science Awards (CTSA’s) Program (October 2005)
- Toxicogenomics Research Consortium
- Other Experiments to Assess Comparability, Reproducibility
- Case study #1
- Case Study #2
- Case Study #3
- Case study #4
- Case Study #5
- Deals
CHAPTER SIX: MARKET ANALYSIS
- Historical
- Affymetrix as Bellwether for Microarray Segment
- Applied Biosystems as Bellwether for qRT-PCR Segment
- Forecasts
- Assumptions
- Competitive Analysis
- Corporate Profiles
- Affymetrix
- Number of Employees
- Estimated 2006 Gene Expression Revenues
- Agilent Technologies
- Number of Employees
- Estimated 2006 Gene Expression Revenues
- Estimated 2006 Life Sciences and Chemical Analysis Group Revenues
- Applied Biosystems
- Number of Employees
- Estimated 2006 Gene Expression Revenues
- Beckman Coulter
- Number of Employees
- Estimated 2006 Gene Expression Revenues
- Combimatrix
- Number of Employees
- 2006 Revenues
- Illumina
- Number of Employees
- 2006 Revenues
- Roche Applied Science
- Number of Employees
- Estimated 2006 Gene Expression Revenues
- Affymetrix
CHAPTER SEVEN: CHALLENGES & STRATEGIC RECOMMENDATIONS
- Challenges
- Next-Generation Sequencers Create Wild Card
- Affymetrix Dominance Decreasing But Still Significant
- Market Complicated by New Gene Expression & Regulation Analysis Products
- Pharmaceutical Industry Tightening Budgets, Scrutinizing Technologies
- Regulations for Diagnostics Still Shaking Out
- RT-PCR Competing Strongly with Microarrays
- SNP Analysis and Copy Number Variation Easier and Popular
- Growth Threatened by Industrialization, Commoditization
- Resistance Towards Diagnostics Using Multiple Markers
- Data Analysis and Management Still Hindering End-Users
- Multiplexing Limitations of Real Time Quantitative PCR
- Longer-Term Prospects Threatened by Proteomics, Metabolomics
- Strategic Recommendations
- Diversify Into Multiple Aspects, Applications
- Partner With Market Leaders
- Provide Software Tools for Comparison Across Platforms, Techniques
- Investigate Intellectual Property and Licensing Possibilities
LIST OF EXHIBITS
CHAPTER TWO: APPLICATIONS
- Table 2-1: Areas Using Gene Expression Profiles in Infectious Disease Research
CHAPTER THREE: INDUSTRY, TECHNOLOGY, AND REGULATORY TRENDS
- Table 3-1: Critical Path Opportunities List (March 2006)
CHAPTER FOUR: PRODUCTS AND SERVICES FOR RESEARCH APPLICATIONS
- Table 4-1: Selected Gene Expression Analysis Products
- Table 4-2: Selected List of Next-Generation Sequencer Products and Technologies
- Table 4-3: Selected List of Next-Generation Sequencer Products and Technologies
- Table 4-4: Selected List of Software Products Available for the Gene Expression Analysis Market
CHAPTER FIVE: CONSORTIA, INITIATIVES, STANDARDIZATION, DEALS
- Table 5-1: Selected Deals Taking Place in the Gene Expression Analysis Market
CHAPTER SIX: MARKET ANALYSIS
- Figure 6-1: Revenues for Microarrays, Instruments, and Reagents (2001- 2007)
- Figure 6-2: Revenues for Microarrays, Instruments, and Reagents with Trendlines (2004- 2007)
- Figure 6-3: Revenues for Real-Time PCR/Applied Genomics (2001-2007)
- Table 6-1: Forcasted Revenues in the Gene Expression Market (2006-2012)
- Figure 6-4: Forecasted Revenues in the Gene Expression Analysis Market (2006-2012)
- Table 6-2: Growth Rates Forecast (2006-2012)
- Figure 6-5: Growth Rates Forecast Chart (2006-2012)
- Table 6-3: Gene Expression Product Revenues Regional Breakdown and Trend 2006
- Figure 6-6: Gene Expression Product Revenues Regional Market Share 2006
- Table 6-4: Regional Shares of Affymetrix’s Overall Revenues (2001-2006)
- Figure 6-7: Trending in the Regional Share of Affymetrix’s Overall Revenues (2001-2006)
- Table 6-5: Estimated Revenues and Market Shares for the Top Vendors in the Gene Expression Analysis
- Figure 6-8: Estimated Market Shares for the Top Vendors in the Gene Expression Analysis Chart
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