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- Activation of the endocannabinoid system as therapeutic approach in a murine model of multiple sclerosis.
- Cardioprotective effects of [5-(2-methyl-5-fluorophenyl)furan-2-ylcarbonyl]guanidine (KR-32568) in an anesthetized rat model of ischemia and reperfusion heart injury.
- Recombinant human erythropoietin pretreatment attenuates myocardial infarct size: a possible mechanism involves heat shock Protein 70 and attenuation of nuclear factor-kappaB.
- Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
- Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin.
- Imiquimod and S-27609 as adjuvants of DNA vaccination in a transgenic murine model of HER2/neu-positive mammary carcinoma.
- Erythropoietin protects the myocardium against reperfusion injury in vitro and in vivo.
- A database of recombinant viruses and recombinant viral vectors available from the RIKEN DNA bank.
- Anti-angiogenic effects and regression of localized murine AML produced by anti-VEGF and anti-Flk-1 antibodies.
- Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
- Apigenin inhibits expression of vascular endothelial growth factor and angiogenesis in human lung cancer cells: implication of chemoprevention of lung cancer.
- Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins.
- Role of c-Jun N-terminal kinase in cerebral vasospasm after experimental subarachnoid hemorrhage.
- Adrenomedullin regenerates alveoli and vasculature in elastase-induced pulmonary emphysema in mice.
- Sildenafil improves alveolar growth and pulmonary hypertension in hyperoxia-induced lung injury.
- Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis.
- Angioarrestin: a unique angiopoietin-related protein with anti-angiogenic properties.
- Chondromodulin-I and tenomodulin: a new class of tissue-specific angiogenesis inhibitors found in hypovascular connective tissues.
- S18886, a selective TP receptor antagonist, inhibits development of atherosclerosis in rabbits.
- Synthesis and biological evaluation of quinoxaline-5,8-diones that inhibit vascular smooth muscle cell proliferation.
- Risk of thrombosis with the use of sirolimus-eluting stents for percutaneous coronary intervention (from registry and clinical trial data).
- IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression.
- GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure.
- Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats.
- Population pharmacokinetics of rituximab (anti-CD20 monoclonal antibody) in rheumatoid arthritis patients during a phase II clinical trial.
- APT070 (Mirococept), a membrane-localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury.
- FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytes.
- Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
- In vitro characterization of leukocyte mimetic for targeting therapeutics to the endothelium using two receptors.
- Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo.
- Poly(ADP-ribose) polymerase: the nuclear target in signal transduction and its role in brain ischemia-reperfusion injury.
- Therapeutic potential of endothelial progenitor cells in cardiovascular diseases.
- Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia.
- Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbits.
- Report of the National Heart, Lung, and Blood Institute working group on outcomes research in cardiovascular disease.
- A phase I clinical trial of a ribozyme-based angiogenesis inhibitor targeting vascular endothelial growth factor receptor-1 for patients with refractory solid tumors.
- Enhanced inhibition of murine tumor and human breast tumor xenografts using targeted delivery of an antibody-endostatin fusion protein.
- Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure.
- Relaxin pretreatment decreases infarct size in male rats after middle cerebral artery occlusion.
- Human recombinant relaxin reduces heart injury and improves ventricular performance in a swine model of acute myocardial infarction.
- Specific inhibition of the endothelin A receptor with ZD4054: clinical and pre-clinical evidence.
- A potency assay for a replication incompetent adenovirus type 5 carrying a human fgf-4 gene.
- Bcl-2 acts in a proangiogenic signaling pathway through nuclear factor-kappaB and CXC chemokines.
- Targeted measles virus vector displaying echistatin infects endothelial cells via alpha(v)beta3 and leads to tumor regression.
- Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis.
- In vitro procoagulant activity induced in endothelial cells by chemotherapy and antiangiogenic drug combinations: modulation by lower-dose chemotherapy.
- Enhanced susceptibility of irradiated tumor vessels to vascular endothelial growth factor receptor tyrosine kinase inhibition.
- The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade.
- The role of sphingosine 1-phosphate receptors in the trafficking of hematopoietic progenitor cells.
- Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia.
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