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- The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.
- Impact of changes in HbA1c, lipids and blood pressure on long-term outcomes in type 2 diabetes patients: an analysis using the CORE Diabetes Model.
- Pyridoxine as a template for the design of antiplatelet agents.
- Neuregulin-1 is neuroprotective and attenuates inflammatory responses induced by ischemic stroke.
- Therapeutic delay and reduced functional status six months after thrombolysis for acute myocardial infarction.
- Comparison of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in the primary prevention of myocardial infarction in hypertensive patients.
- Effects of edaravone on reperfusion injury in patients with acute myocardial infarction.
- Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia.
- Pharmacological evidence for a key role of voltage-gated K+ channels in the function of rat aortic smooth muscle cells.
- Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults.
- Regression of hypertensive left ventricular hypertrophy by losartan compared with atenolol: the Losartan Intervention for Endpoint Reduction in Hypertension (LIFE) trial.
- Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study.
- PREDICT modeling and in-silico screening for G-protein coupled receptors.
- Gemfibrozil for secondary prevention of cardiovascular events in mild to moderate chronic renal insufficiency.
- Oral administration of K-11706 inhibits GATA binding activity, enhances hypoxia-inducible factor 1 binding activity, and restores indicators in an in vivo mouse model of anemia of chronic disease.
- Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors.
- TZT-1027 elucidates antitumor activity through direct cytotoxicity and selective blockade of blood supply.
- Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure.
- Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.
- Comparative effects of microplasmin and tissue-type plasminogen activator (tPA) on cerebral hemorrhage in a middle cerebral artery occlusion model in mice.
- C-type natriuretic peptide ameliorates monocrotaline-induced pulmonary hypertension in rats.
- CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation.
- Neuroprotective effect of tacrolimus (FK506) on ischemic brain damage following permanent focal cerebral ischemia in the rat.
- Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.
- Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial.
- Downregulation of matrix metalloproteinases and collagens and suppression of cardiac fibrosis by inhibition of the proteasome.
- Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
- Dipeptidomimetic ketomethylene isosteres as pro-moieties for drug transport via the human intestinal di-/tripeptide transporter hPEPT1: design, synthesis, stability, and biological investigations.
- Identification of 4-piperazin-1-yl-quinazoline template based aryl and benzyl thioureas as potent, selective, and orally bioavailable inhibitors of platelet-derived growth factor (PDGF) receptor.
- Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.
- Synthesis and vasorelaxant properties of hybrid molecules out of NO-donors and the beta-receptor blocking drug propranolol.
- A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides.
- Comparison of three-year outcomes after coronary stenting versus coronary artery bypass grafting in patients with multivessel coronary disease, including involvement of the left anterior descending coronary artery proximally (a subanalysis of the arterial revascularization therapies study trial).
- Angiopoietin-3 inhibits pulmonary metastasis by inhibiting tumor angiogenesis.
- Nitric oxide-releasing aspirin derivative, NCX 4016, promotes reparative angiogenesis and prevents apoptosis and oxidative stress in a mouse model of peripheral ischemia.
- Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice.
- Liver delivery of NO by NCX-1000 protects against acute liver failure and mitochondrial dysfunction induced by APAP in mice.
- Diabetes mellitus and unstable coronary artery disease: improved clinical outcome of coronary artery stenting in an era of glycoprotein IIb/IIIa inhibitors and lipid-lowering therapy.
- Treatment with {alpha}-phenyl-N-tert-butylnitrone, a free radical-trapping agent, abrogates inflammatory cytokine gene expression during alloimmune activation in rat cardiac allografts.
- Role of the renin-angiotensin system in hepatic ischemia reperfusion injury in rats.
- Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial.
- Synthesis and structure-activity relationships of phenoxypyridine derivatives as novel inhibitors of the sodium-calcium exchanger.
- The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis.
- Neutralization of the chemokine CXCL10 enhances tissue sparing and angiogenesis following spinal cord injury.
- Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
- Outcome in elderly patients undergoing primary coronary intervention for acute myocardial infarction: results from the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications (CADILLAC) trial.
- A double blind randomized trial to compare the effects of eprosartan and enalapril on blood pressure, platelets, and endothelium function in patients with essential hypertension.
- Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.
- The effect of PARP inhibitor on ischaemic cell death, its related inflammation and survival signals.
- Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models.
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