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- In vivo humoral immune responses to isolated pneumococcal polysaccharides are dependent on the presence of associated TLR ligands.
- Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque.
- Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection.
- Phosphatidylinositol 3-kinase is required for rhinovirus-induced airway epithelial cell interleukin-8 expression.
- Defining invasive fungal infections in neutropenic or stem cell transplant patients.
- Pharmacological properties of a new antimalarial bisthiazolium salt, T3, and a corresponding prodrug, TE3.
- Development of a novel targeting system for lethal photosensitization of antibiotic-resistant strains of Staphylococcus aureus.
- Design of a small-molecule entry inhibitor with activity against primary measles virus strains.
- High-throughput human immunodeficiency virus type 1 (HIV-1) full replication assay that includes HIV-1 Vif as an antiviral target.
- Effects of intratracheal administration of novispirin G10 on a rat model of mucoid Pseudomonas aeruginosa lung infection.
- Interleukin-8-derived peptide has antibacterial activity.
- Effect of simvastatin, an established lipid-lowering drug, on pulmonary Chlamydia pneumoniae infection in mice.
- Postantibiotic effect of DX-619 against 16 gram-positive organisms.
- Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice.
- Rab9 GTPase is required for replication of human immunodeficiency virus type 1, filoviruses, and measles virus.
- Deletion of gpUL132, a structural component of human cytomegalovirus, results in impaired virus replication in fibroblasts.
- The Src family kinase c-Yes is required for maturation of West Nile virus particles.
- Molecular footprint of drug-selective pressure in a human immunodeficiency virus transmission chain.
- Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model.
- Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA.
- High-dose interferon-alpha2b induction therapy in combination with ribavirin for treatment of chronic hepatitis C in patients with non-response or relapse after interferon-alpha monotherapy.
- RSV-induced prostaglandin E2 production occurs via cPLA2 activation: role in viral replication.
- Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cells.
- Inactivation of retroviruses with preservation of structural integrity by targeting the hydrophobic domain of the viral envelope.
- Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain.
- Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
- Transfection of Trypanosoma cruzi with host CD40 ligand results in improved control of parasite infection.
- Role of NADase in virulence in experimental invasive group A streptococcal infection.
- Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies.
- Coronaviruses as vectors: stability of foreign gene expression.
- Low TRBP levels support an innate human immunodeficiency virus type 1 resistance in astrocytes by enhancing the PKR antiviral response.
- Oxadiazols: a new class of rationally designed anti-human immunodeficiency virus compounds targeting the nuclear localization signal of the viral matrix protein.
- Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase.
- An orally bioavailable antipoxvirus compound (ST-246) inhibits extracellular virus formation and protects mice from lethal orthopoxvirus Challenge.
- A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.
- Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study.
- Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.
- Antiviral activity of GW678248, a novel benzophenone nonnucleoside reverse transcriptase inhibitor.
- Newly designed six-membered azasugar nucleotide-containing phosphorothioate oligonucleotides as potent human immunodeficiency virus type 1 inhibitors.
- Multicenter study to determine antibody concentrations and assess the safety of administration of INH-A21, a donor-selected human Staphylococcal immune globulin, in low-birth-weight infants.
- Evaluation of LBM415 (NVP PDF-713), a novel peptide deformylase inhibitor, for treatment of experimental Mycoplasma pneumoniae pneumonia.
- Efficacy and safety of a novel once-daily extended-release ciprofloxacin tablet formulation for treatment of uncomplicated urinary tract infection in women.
- In vitro and in vivo antibacterial activities of SM-216601, a new broad-spectrum parenteral carbapenem.
- Inhibition of hepatitis C virus replication by antimonial compounds.
- Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporin.
- Antibacterial activity of REP8839, a new antibiotic for topical use.
- Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.
- Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
- Efficacy of telavancin (TD-6424), a rapidly bactericidal lipoglycopeptide with multiple mechanisms of action, in a murine model of pneumonia induced by methicillin-resistant Staphylococcus aureus.
- In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867.
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