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- The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria.
- Novel pathway of human immunodeficiency virus type 1 uptake and release in astrocytes.
- Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally.
- Quantitative comparison of the HSV-1 and HSV-2 transcriptomes using DNA microarray analysis.
- Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034.
- Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole.
- 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase.
- SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.
- Synthesis of cyclopentenyl carbocyclic nucleosides as potential antiviral agents against orthopoxviruses and SARS.
- Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors.
- Transforming growth factor-beta receptor inhibition enhances adenoviral infectability of carcinoma cells via up-regulation of Coxsackie and Adenovirus Receptor in conjunction with reversal of epithelial-mesenchymal transition.
- Therapeutic short hairpin RNA expression in the liver: viral targets and vectors.
- Local thymic caspase-9 inhibition improves survival during polymicrobial sepsis in mice.
- Intranasal immunization with human papillomavirus type 16 capsomeres in the presence of non-toxic cholera toxin-based adjuvants elicits increased vaginal immunoglobulin levels.
- Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole.
- An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase.
- Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate.
- Use of electrochemical DNA biosensors for rapid molecular identification of uropathogens in clinical urine specimens.
- High interlaboratory reproducibility of DNA sequence-based typing of bacteria in a multicenter study.
- CCL5 modulates pneumococcal immunity and carriage.
- OX40 ligation of CD4+ T cells enhances virus-specific CD8+ T cell memory responses independently of IL-2 and CD4+ T regulatory cell inhibition.
- Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States.
- The effect of pegylated interferon-alpha on the treatment of lamivudine resistant chronic HBeAg positive hepatitis B virus infection.
- Ultra-potent P1 modified arylsulfonamide HIV protease inhibitors: the discovery of GW0385.
- Mechanistic basis for the action of new cephalosporin antibiotics effective against methicillin- and vancomycin-resistant Staphylococcus aureus.
- Thyroid dysfunction in patients with chronic hepatitis C receiving a combined therapy of interferon and ribavirin: incidence, associated factors and prognosis.
- Fully automated quantitation of hepatitis B virus (HBV) DNA in human plasma by the COBAS AmpliPrep/COBAS TaqMan system.
- Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells.
- Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2.
- A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees.
- The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication.
- N-thiolated 2-oxazolidinones: a new family of antibacterial agents for methicillin-resistant Staphylococcus aureus and Bacillus anthracis.
- Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
- HIV entry inhibitors: mechanisms of action and resistance pathways.
- The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock.
- Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.
- Chitinase 3-like-1 exacerbates intestinal inflammation by enhancing bacterial adhesion and invasion in colonic epithelial cells.
- Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners.
- Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens.
- Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody.
- Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor.
- An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses.
- A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.
- Serotonin transporter mRNA expression is decreased by lamivudine and ribavirin and increased by interferon in immune cells.
- Week-12 response to therapy as a predictor of week 24, 48, and 96 outcome in patients receiving the HIV fusion inhibitor enfuvirtide in the T-20 versus Optimized Regimen Only (TORO) trials.
- Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.
- Design and synthesis of 2,3,4,9-tetrahydro-1H-carbazole and 1,2,3,4-tetrahydro-cyclopenta[b]indole derivatives as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase.
- Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands.
- Investigation of the mechanism of action of 3-(4-bromophenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-one against Candida albicans by flow cytometry.
- N-Thiolated beta-lactam antibacterials: effects of the N-organothio substituent on anti-MRSA activity.
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