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- Design, synthesis, and biological activity of potent and selective inhibitors of mast cell tryptase.
- Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13.
- Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides.
- Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists.
- Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
- Randomized phase II trial of the efficacy and safety of trastuzumab combined with docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer administered as first-line treatment: the M77001 study group.
- Increased rejection of primary tumors in mice lacking B cells: inhibition of anti-tumor CTL and TH1 cytokine responses by B cells.
- Affinity selection to papain yields potent peptide inhibitors of cathepsins L, B, H, and K.
- Potentiation of beta-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C.
- 1Alpha,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells.
- Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: orally active prostacyclin mimetics. Part 3.
- Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice.
- Effects of the kinase inhibitor CGP41251 (PKC 412) on lymphocyte activation and TNF-alpha production.
- Administration of a peptide inhibitor of alpha4-integrin inhibits the development of experimental autoimmune uveitis.
- Analysis of a 17-amino acid residue, virus-neutralizing microantibody.
- Design of small-sized libraries by combinatorial assembly of linkers and functional groups to a given scaffold: application to the structure-based optimization of a phosphodiesterase 4 inhibitor.
- 3-[4-(methylsulfonyl)phenyl]-5-(trifluoromethyl)(2-pyridyl) phenyl ketone as a potent and orally active cyclooxygenase-2 selective inhibitor: synthesis and biological evaluation.
- Peripheral benzodiazepine receptor ligand PK11195 reduces microglial activation and neuronal death in quinolinic acid-injected rat striatum.
- Oxytocin protects against sepsis-induced multiple organ damage: role of neutrophils.
- Autoantigens act as tissue-specific chemoattractants.
- A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity.
- A mimotope peptide-based anti-cancer vaccine selected by BAT monoclonal antibody.
- Effects of rapamycin on the arterial inflammatory response in atherosclerotic plaques in Apo-E knockout mice.
- Protective effects of PG490-88 on chronic allograft rejection by changing intragraft gene expression profiles.
- The malononitrilamide FK778 inhibits activation of NF-kappaB in human dendritic cells.
- A single course of anti-CD3 monoclonal antibody hOKT3gamma1(Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of type 1 diabetes.
- Induction of T-cell immunity to antiretroviral drug-resistant human immunodeficiency virus type 1.
- G-protein signaling triggered by R5 human immunodeficiency virus type 1 increases virus replication efficiency in primary T lymphocytes.
- Structural bioinformatics-based design of selective, irreversible kinase inhibitors.
- Effects of Atorvastatin on Th polarization in patients with acute myocardial infarction.
- The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway.
- Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis.
- ErbB2 activity is required for airway epithelial repair following neutrophil elastase exposure.
- Phthalazine PDE IV inhibitors: conformational study of some 6-methoxy-1,4-disubstituted derivatives.
- Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages.
- Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo.
- RON-regulated innate immunity is protective in an animal model of multiple sclerosis.
- Biological properties of a human compact anti-ErbB2 antibody.
- A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.
- A role for ADAM12 in breast tumor progression and stromal cell apoptosis.
- Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu In vivo model of human multiple myeloma.
- Anti-tumor responses induced by chemokine CCL19 transfected into an ovarian carcinoma model via fiber-mutant adenovirus vector.
- Design of effective immunotherapy for human autoimmunity.
- Treatment of severe autoimmune disease by stem-cell transplantation.
- A phase II multicenter study of visilizumab, humanized anti-CD3 antibody, to treat steroid-refractory acute graft-versus-host disease.
- Hydroxymethylglutaryl co-enzyme A reductase inhibition attenuates endotoxin-mediated inflammatory responses.
- Cannabinoid influence on cytokine profile in multiple sclerosis.
- The structure of interleukin-2 complexed with its alpha receptor.
- Effects of combination M40403 and dexamethasone therapy on joint disease in a rat model of collagen-induced arthritis.
- Interleukin-4 can be a key positive regulator of inflammatory arthritis.
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