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- Tissue-specific expression and dimerization of the endoplasmic reticulum oxidoreductase Ero1beta.
- Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease.
- Characteristics of intestinal dendritic cells in inflammatory bowel diseases.
- Growth hormone inhibits signal transducer and activator of transcription 3 activation and reduces disease activity in murine colitis.
- Protection mediated by antibodies to iron-regulated outer-membrane proteins of S. typhi in a mouse peritonitis model.
- Pharmacogenomics of tumor necrosis factor antagonists in rheumatoid arthritis.
- Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688.
- Down-regulation of the anti-inflammatory protein annexin A1 in cystic fibrosis knock-out mice and patients.
- A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection.
- Vascular interleukin-10 protects against LPS-induced vasomotor dysfunction.
- Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids.
- Inhibition of c-kit tyrosine kinase by imatinib mesylate induces apoptosis in mast cells in rheumatoid synovia: a potential approach to the treatment of arthritis.
- Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice.
- Expression of interleukin-4 by recombinant respiratory syncytial virus is associated with accelerated inflammation and a nonfunctional cytotoxic T-lymphocyte response following primary infection but not following challenge with wild-type virus.
- CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain.
- Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication.
- Human immunodeficiency virus reactivation by phorbol esters or T-cell receptor ligation requires both PKCalpha and PKCtheta.
- Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.
- Gene expression profiling of arthritis using a QTL chip reveals a complex gene regulation of the Cia5 region in mice.
- Tumor necrosis factor receptor 2 (TNFR2) signaling is negatively regulated by a novel, carboxyl-terminal TNFR-associated factor 2 (TRAF2)-binding site.
- A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.
- Association between prostaglandin E receptor subtype EP4 overexpression and unstable phenotype in atherosclerotic plaques in human.
- Intensive treatment with atorvastatin reduces inflammation in mononuclear cells and human atherosclerotic lesions in one month.
- A new BAL fluid instillation and aspiration technique: a multicenter randomized study.
- Lipopolysaccharide stimulates the secretion of the amyloid precursor protein via a protein kinase C-mediated pathway.
- The effects of hormone therapy on the markers of inflammation and endothelial function and plasma matrix metalloproteinase-9 level in postmenopausal women: the postmenopausal estrogen progestin intervention (PEPI) trial.
- Nociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats.
- Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: nitric oxide as a protective factor.
- A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling.
- Some structural determinants of the antiproliferative effect of heparin-like molecules on human airway smooth muscle.
- The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages.
- rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats.
- Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality.
- Aerosolized hyaluronan limits airspace enlargement in a mouse model of cigarette smoke-induced pulmonary emphysema.
- Thrombin induces DNA synthesis and phosphoinositide hydrolysis in airway smooth muscle by activation of distinct receptors.
- Administration of agonistic anti-4-1BB monoclonal antibody leads to the amelioration of inflammatory bowel disease.
- Anti-TWEAK monoclonal antibodies reduce immune cell infiltration in the central nervous system and severity of experimental autoimmune encephalomyelitis.
- Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread.
- MEN16132, a novel potent and selective nonpeptide kinin B2 receptor antagonist: in vivo activity on bradykinin-induced bronchoconstriction and nasal mucosa microvascular leakage in anesthetized guinea pigs.
- Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus.
- A peptide carrier with a built-in vaccine adjuvant: construction of immunogenic conjugates.
- Antagonism of the interleukin-1 receptor following traumatic brain injury in the mouse reduces the number of nitric oxide synthase-2-positive cells and improves anatomical and functional outcomes.
- Effects of nifedipine GITS 20 mg or enalapril 20 mg on blood pressure and inflammatory markers in patients with mild-moderate hypertension.
- Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2.
- RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.
- Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase.
- CD8 alpha+, but not CD8 alpha-, dendritic cells tolerize Th2 responses via contact-dependent and -independent mechanisms, and reverse airway hyperresponsiveness, Th2, and eosinophil responses in a mouse model of asthma.
- Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.
- Opposing effects of CXCR3 and CCR5 deficiency on CD8+ T cell-mediated inflammation in the central nervous system of virus-infected mice.
- CD43 is required for optimal growth inhibition of Mycobacterium tuberculosis in macrophages and in mice.
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