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- CC chemokine ligand 19 secreted by mature dendritic cells increases naive T cell scanning behavior and their response to rare cognate antigen.
- ERK1-deficient mice show normal T cell effector function and are highly susceptible to experimental autoimmune encephalomyelitis.
- Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice.
- Demonstration of autoimmunity in the tight skin-2 mouse: a model for scleroderma.
- IL-10 from regulatory T cells determines vaccine efficacy in murine Leishmania major infection.
- Identification of high and low responders to lipopolysaccharide in normal subjects: an unbiased approach to identify modulators of innate immunity.
- Prostaglandin E2 stimulates granulocyte colony-stimulating factor production via the prostanoid EP2 receptor in mouse peritoneal neutrophils.
- Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1.
- CCR3 expression and function in asthmatic airway smooth muscle cells.
- TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques.
- Reductions in health-related quality of life in patients with ankylosing spondylitis and improvements with etanercept therapy.
- Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing.
- Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution.
- Effect of low-dose ciclesonide on allergen-induced responses in subjects with mild allergic asthma.
- Roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor, attenuates allergen-induced asthmatic reactions.
- Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli.
- Patterns of inflammation associated with peripheral arterial disease: the InCHIANTI study.
- Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis.
- CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells.
- Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease.
- Attenuation of acid induced oesophagitis in VR-1 deficient mice.
- Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720.
- Spontaneous remyelination following prolonged inhibition of alpha4 integrin in chronic EAE.
- Targeted delivery of therapeutic oligonucleotides to pulmonary circulation.
- Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades.
- CD44, but not l-selectin, is critically involved in leucocyte migration into the skin in a murine model of allergic dermatitis.
- Effects of the active metabolite of leflunomide, A77 1726, on cytokine release and the MAPK signalling pathway in human rheumatoid arthritis synoviocytes.
- Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury.
- Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease.
- The TRPM cation channels in the immune context.
- Effect of short-term treatment with pravastatin on cytokines and cytokine receptors in patients with chronic heart failure due to ischemic and nonischemic disease.
- IL-10-dependent down-regulation of MHC class II expression level on monocytes by peritoneal fluid from endometriosis patients.
- Effects of central and peripheral depletion of serotonergic system on carrageenan-induced paw oedema.
- Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis.
- An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1.
- Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways.
- Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 1: eradication of Helicobacter in the cachexia of idiopathic parkinsonism.
- Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 2: response of facets of clinical idiopathic parkinsonism to Helicobacter pylori eradication. A randomized, double-blind, placebo-controlled efficacy study.
- Role of chronic infection and inflammation in the gastrointestinal tract in the etiology and pathogenesis of idiopathic parkinsonism. Part 3: predicted probability and gradients of severity of idiopathic parkinsonism based on H. pylori antibody profile.
- Indolin-2-ones with high in vivo efficacy in a model for multiple sclerosis.
- Histidine inhibits oxidative stress- and TNF-alpha-induced interleukin-8 secretion in intestinal epithelial cells.
- A pilot study of oral calcitriol (1,25-dihydroxyvitamin D3) for relapsing-remitting multiple sclerosis.
- DNA vaccination with an insulin construct and a chimeric protein binding to both CTLA4 and CD40 ameliorates type 1 diabetes in NOD mice.
- Suppressor alphabeta T lymphocytes control innate resistance to endotoxic shock.
- A GPIIb/IIIa bioreactor for specific treatment of immune thrombocytopenic purpura, an autoimmune disease. Preparation, in vitro characterization, and preliminary proof-of-concept animal studies.
- A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons.
- BP-1107 [{2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxy]-ethyl}-methyl-amide]: a novel synthetic thiazolidinedione that inhibits epidermal hyperplasia in psoriatic skin-severe-combined immunodeficient mouse transplants after topical application.
- Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes.
- Overexpression of hyaluronan synthases alters vascular smooth muscle cell phenotype and promotes monocyte adhesion.
- The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1.
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