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- Targeted expression of the anti-apoptotic gene CrmA to NOD pancreatic islets protects from autoimmune diabetes.
- Activation of NFkappaB is inhibited by curcumin and related enones.
- CD28 superagonists put a break on autoimmunity by preferentially activating CD4+CD25+ regulatory T cells.
- A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression.
- Thyroid receptor ligands. Part 5: novel bicyclic agonist ligands selective for the thyroid hormone receptor beta.
- Infliximab for induction and maintenance therapy for ulcerative colitis.
- Potential role of interleukin-18 in liver disease associated with insulin resistance.
- Cutting edge: lectin-like transcript-1 is a ligand for the inhibitory human NKR-P1A receptor.
- Silencing human NKG2D, DAP10, and DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells.
- CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.
- Identification of T cell-restricted genes, and signatures for different T cell responses, using a comprehensive collection of microarray datasets.
- Targeting LFA-1 and cd154 suppresses the in vivo activation and development of cytolytic (cd4-Independent) CD8+ T cells.
- Retinoid x receptor agonists increase bcl2a1 expression and decrease apoptosis of naive T lymphocytes.
- The sphingosine 1-phosphate receptor agonist FTY720 differentially affects the sequestration of CD4+/CD25+ T-regulatory cells and enhances their functional activity.
- Stabilized beta-catenin extends thymocyte survival by up-regulating Bcl-xL.
- The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells.
- Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.
- Disparate regulation and function of the class A scavenger receptors SR-AI/II and MARCO.
- Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells.
- Elevated T regulatory cells in long-term stable transplant tolerance in rhesus macaques induced by anti-CD3 immunotoxin and deoxyspergualin.
- Erythromycin differentially inhibits lipopolysaccharide- or poly(I:C)-induced but not peptidoglycan-induced activation of human monocyte-derived dendritic cells.
- Allergen-induced airway hyperresponsiveness mediated by cyclooxygenase inhibition is not dependent on 5-lipoxygenase or IL-5, but is IL-13 dependent.
- Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma.
- Global natural regulatory T cell depletion in active systemic lupus erythematosus.
- CXCL10 DNA vaccination prevents spontaneous diabetes through enhanced beta cell proliferation in NOD mice.
- Activation of naïve B lymphocytes via CD81, a pathogenetic mechanism for hepatitis C virus-associated B lymphocyte disorders.
- Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes.
- Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection.
- A novel, selective, and orally available antagonist for CC chemokine receptor 3.
- Treatment with infliximab is associated with increased markers of bone formation in patients with Crohn's disease.
- Adenoviral bcl-2 transfer improves survival and early graft function after ischemia and reperfusion in rat liver transplantation.
- Lipid microarrays identify key mediators of autoimmune brain inflammation.
- Glycogen synthase kinase-3 is an in vivo regulator of hematopoietic stem cell repopulation.
- Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer.
- CCR2 modulates inflammatory and metabolic effects of high-fat feeding.
- The overproduction of nitric oxide associated with neutrophilic predominance is relevant to airway mycotic infections in asthmatics undergoing prolonged glucocorticoid treatment.
- Translocation of ethanolamine phosphoglyceride is required for initiation of apoptotic death in OLN-93 oligodendroglial cells.
- Impact of venlafaxine on gene expression profile in lymphocytes of the elderly with major depression--evolution of antidepressants and the role of the "neuro-immune" system.
- Outcome of patients with active ankylosing spondylitis after two years of therapy with etanercept: clinical and magnetic resonance imaging data.
- Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes.
- The immunomodulator ginsan induces resistance to experimental sepsis by inhibiting Toll-like receptor-mediated inflammatory signals.
- In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031.
- Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets.
- Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment.
- Suppression of mast cell degranulation by a novel ceramide kinase inhibitor, the F-12509A olefin isomer K1.
- Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia.
- Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.
- BDNF-mediated enhancement of inflammation and injury in the aging heart.
- Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib.
- Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura.
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