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- The phosphodiesterase 4 inhibitor AWD 12-281 is active in a new guinea-pig model of allergic skin inflammation predictive of human skin penetration and suppresses both Th1 and Th2 cytokines in mice.
- A 10-aa-long sequence in SLP-76 upstream of the Gads binding site is essential for T cell development and function.
- Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study.
- B lymphocyte stimulator (BLyS) isoforms in systemic lupus erythematosus: disease activity correlates better with blood leukocyte BLyS mRNA levels than with plasma BLyS protein levels.
- THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis.
- Partial protection against collagen antibody-induced arthritis in PARP-1 deficient mice.
- Synthesis and anti-inflammatory activity of a series of N-substituted naproxen glycolamides: nitric oxide-donor naproxen prodrugs.
- Design, synthesis, and biological evaluation of 1,3-diarylprop-2-en-1-ones : a novel class of cyclooxygenase-2 inhibitors.
- The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C.
- Effects of esomeprazole 40 mg twice daily on asthma: a randomized placebo-controlled trial.
- Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway.
- Patient, disease, and therapy-related factors that influence discontinuation of disease-modifying antirheumatic drugs: a population-based incidence cohort of patients with rheumatoid arthritis.
- Activation of cerebral endothelium is required for mononuclear cell recruitment in a novel in vitro model of brain inflammation.
- Agents that act by different mechanisms modulate the activity of protein kinase CbetaII isozyme in the rat spinal cord during peripheral inflammation.
- Phenylsulphonyl urenyl chalcone derivatives as dual inhibitors of cyclo-oxygenase-2 and 5-lipoxygenase.
- Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.
- Encapsulation of the immune potentiators MPL and RC529 in PLG microparticles enhances their potency.
- Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice.
- A humanized anti-human Fas antibody, R-125224, induces apoptosis in type I activated lymphocytes but not in type II cells.
- Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis.
- TLR7 ligand prevents allergen-induced airway hyperresponsiveness and eosinophilia in allergic asthma by a MYD88-dependent and MK2-independent pathway.
- Phosphodiesterase inhibition decreases nuclear factor-kappaB activation and shifts the cytokine response toward anti-inflammatory activity in acute endotoxemia.
- Pan-selectin antagonism improves psoriasis manifestation in mice and man.
- Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma.
- Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice.
- Pioglitazone-induced insulin sensitization improves vascular endothelial function in nondiabetic patients with essential hypertension.
- Prevalence and treatment of psoriasis in the United Kingdom: a population-based study.
- Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women.
- A novel lipid A from Halomonas magadiensis inhibits enteric LPS-induced human monocyte activation.
- Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch.
- The nonspecific anti-inflammatory therapy with methotrexate for patients with chronic heart failure.
- Radiation treatment of acute inflammation in mice.
- Pigment epithelium-derived factor (PEDF) is an endogenous antiinflammatory factor.
- The chemokines CXCL9 and CXCL10 promote a protective immune response but do not contribute to cardiac inflammation following infection with Trypanosoma cruzi.
- The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi.
- Percutaneous transluminal angioplasty in severe diabetic foot ischemia: outcomes and prognostic factors.
- Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs.
- Purine P1 receptor-dependent immunostimulatory effects of antiviral acyclic analogues of adenine and 2,6-diaminopurine.
- Positive and negative effects of thalidomide on refractory cutaneous lupus erythematosus.
- RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.
- Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy.
- A randomized comparison of pioglitazone to inhibit restenosis after coronary stenting in patients with type 2 diabetes.
- Impaired coronary endothelium-dependent vasodilation is associated with microalbuminuria in patients with type 2 diabetes and angiographically normal coronary arteries.
- Neuroprotective actions of endogenous interleukin-1 receptor antagonist (IL-1ra) are mediated by glia.
- Immune responses to an encapsulated allogeneic islet beta-cell line in diabetic NOD mice.
- Soluble CD40 ligand and interleukin-6 in the coronary circulation after acute myocardial infarction.
- Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors.
- Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.
- Apoptotic cells, at all stages of the death process, trigger characteristic signaling events that are divergent from and dominant over those triggered by necrotic cells: Implications for the delayed clearance model of autoimmunity.
- The role of human HtrA1 in arthritic disease.
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