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- Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors.
- Adenoviral vector-mediated gene transfer of IL-13Ralpha2 chain followed by IL-13 cytotoxin treatment offers potent targeted therapy for cytotoxin-resistant cancers.
- A two year randomised controlled trial of intramuscular depot steroids in patients with established rheumatoid arthritis who have shown an incomplete response to disease modifying antirheumatic drugs.
- Pharmacological characterization of CXC chemokine receptor 3 ligands and a small molecule antagonist.
- Connective tissue growth factor is overexpressed in complicated atherosclerotic plaques and induces mononuclear cell chemotaxis in vitro.
- Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation.
- Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo.
- A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.
- Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.
- Neovastat (AE-941) inhibits the airway inflammation and hyperresponsiveness in a murine model of asthma.
- Use of sirolimus and low-dose calcineurin inhibitor in lung transplant recipients with renal impairment: results of a controlled pilot study.
- Quinolinium salt as a potent inhibitor of lymphocyte apoptosis.
- Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
- Effects of PRI-2191--a low-calcemic analog of 1,25-dihydroxyvitamin D3 on the seizure-induced changes in brain gene expression and immune system activity in the rat.
- Design, synthesis and characterization of a novel class of coumarin-based inhibitors of inducible nitric oxide synthase.
- Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents.
- Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of betaII tryptase.
- In silico ADME modelling: prediction models for blood-brain barrier permeation using a systematic variable selection method.
- Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats.
- Attenuating effect of H+K+ATPase inhibitors on airway cough hypersensitivity induced by allergic airway inflammation in guinea-pigs.
- Therapeutic administration of Budesonide ameliorates allergen-induced airway remodelling.
- Protective mechanisms of a metalloporphyrinic peroxynitrite decomposition catalyst, WW85, in rat cardiac transplants.
- A novel effect for annexin 1-derived peptide ac2-26: reduction of allergic inflammation in the rat.
- Target-directed proteolysis at the ribosome.
- Characterization of a monoclonal antibody that antagonizes the function of human endostatin.
- Cyclosporin A is a broad-spectrum multidrug resistance modulator.
- Prior elevation of IL-18 promotes rapid early IFN-gamma production during staphylococcal infection.
- Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.
- Effect of a novel interleukin-5 receptor antagonist, YM-90709, on antigen-induced eosinophil infiltration into the airway of BDF1 mice.
- Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage.
- Microglial NADPH oxidase is a novel target for femtomolar neuroprotection against oxidative stress.
- Recognition of bacterial glycosphingolipids by natural killer T cells.
- Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections.
- Evaluating the prophylactic potential of the phtalimide derivative LASSBio 552 on allergen-evoked inflammation in rats.
- Protection against bleomycin-induced lung injury by IL-18 in mice.
- Chronic inflammatory pain leads to increased blood-brain barrier permeability and tight junction protein alterations.
- Immunological role of neuronal receptor vanilloid receptor 1 expressed on dendritic cells.
- TIM-1 induces T cell activation and inhibits the development of peripheral tolerance.
- Study on hepatoprotective effect of peptide S-8300 from shark liver.
- A double-blind, randomized, controlled study of oral pirfenidone for treatment of secondary progressive multiple sclerosis.
- Stimulation of CD95-induced apoptosis in T-cells by a subtype specific neutral sphingomyelinase inhibitor.
- Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura.
- The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP.
- Inhibitory effect of the 4-aminotetrahydroquinoline derivatives, selective chemoattractant receptor-homologous molecule expressed on T helper 2 cell antagonists, on eosinophil migration induced by prostaglandin D2.
- Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis.
- ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro.
- Engineered vascular-targeting antibody-interferon-gamma fusion protein for cancer therapy.
- Design of potent and selective 2-aminobenzimidazole-based p38alpha MAP kinase inhibitors with excellent in vivo efficacy.
- Druggability indices for protein targets derived from NMR-based screening data.
- High-throughput lipophilicity measurement with immobilized artificial membranes.
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