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- Roles of PPAR delta in lipid absorption and metabolism: a new target for the treatment of type 2 diabetes.
- Hepatocyte growth factor is constitutively produced by donor-derived bone marrow cells and promotes regeneration of pancreatic beta-cells.
- Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
- Structure-activity relationship of a series of cyclohexylpiperidines bearing an amide side chain as antagonists of the human melanocortin-4 receptor.
- Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors.
- 1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists.
- GH-releasing peptides improve cardiac dysfunction and cachexia and suppress stress-related hormones and cardiomyocyte apoptosis in rats with heart failure.
- Insulin resistance is a cause of steatosis and fibrosis progression in chronic hepatitis C.
- 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-gamma activators.
- Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis.
- A pilot randomized controlled trial of renal protection with pioglitazone in diabetic nephropathy.
- Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial.
- Relaxin regulates collagen overproduction associated with experimental progressive renal fibrosis.
- Expression of gremlin, a bone morphogenetic protein antagonist, in human diabetic nephropathy.
- A potency assay for a replication incompetent adenovirus type 5 carrying a human fgf-4 gene.
- Substitution of nevirapine or efavirenz for protease inhibitor versus lipid-lowering therapy for the management of dyslipidaemia.
- Phosphorylated heat shock protein 27 is involved in enhanced heart tolerance to ischemia in short-term type 1 diabetic rats.
- Efficacy of ACE-inhibitor therapy on renal disease in glycogen storage disease type 1: a multicentre retrospective study.
- Use of bivalirudin during percutaneous coronary intervention in patients with diabetes mellitus: an analysis from the randomized evaluation in percutaneous coronary intervention linking angiomax to reduced clinical events (REPLACE)-2 trial.
- Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits.
- Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors.
- Nitric oxide induces osteoblast apoptosis through a mitochondria-dependent pathway.
- Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability.
- A novel pathophysiological mechanism for osteoporosis suggested by an in vivo gene expression study of circulating monocytes.
- Fas binding to calmodulin regulates apoptosis in osteoclasts.
- Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy.
- Steady-state pharmacokinetics of a novel extended-release metformin formulation.
- Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
- Regenerative and therapeutic effects of heparin-binding epidermal growth factor-like growth factor on diabetes by gene transduction through retrograde pancreatic duct injection of adenovirus vector.
- Design and evaluation of compound metformin/glipizide elementary osmotic pump tablets.
- High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.
- Zonisamide in the treatment of painful diabetic neuropathy: a randomized, double-blind, placebo-controlled pilot study.
- Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand-induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.
- Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes.
- Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury.
- Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
- Microalbuminuria as a marker of cardiovascular risk in patients with type 2 diabetes.
- Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists.
- Dibenzodioxocinones--a new class of CETP inhibitors.
- Streptozotocin-induced diabetic nephropathy in rats: the role of inflammatory cytokines.
- Metabolic effects of pioglitazone in combination with insulin in patients with type 2 diabetes mellitus whose disease is not adequately controlled with insulin therapy: results of a six-month, randomized, double-blind, prospective, multicenter, parallel-group study.
- Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts.
- A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists.
- Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist.
- P2-P3 conformationally constrained ketoamide-based inhibitors of cathepsin K.
- Socs1 deficiency enhances hepatic insulin signaling.
- Autocrine action of adiponectin on human fat cells prevents the release of insulin resistance-inducing factors.
- Heparanase-1 gene expression and regulation by high glucose in renal epithelial cells: a potential role in the pathogenesis of proteinuria in diabetic patients.
- Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process.
- Rosiglitazone improves glomerular hyperfiltration, renal endothelial dysfunction, and microalbuminuria of incipient diabetic nephropathy in patients.
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