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- Synthesis and SAR of substituted tetrahydrocarbazole derivatives as new NPY-1 antagonists.
- Pioglitazone-induced insulin sensitization improves vascular endothelial function in nondiabetic patients with essential hypertension.
- Proteinuria and metabolic syndrome as predictors of cardiovascular death in non-diabetic and type 2 diabetic men and women.
- Effect of early addition of rosiglitazone to sulphonylurea therapy in older type 2 diabetes patients (>60 years): the Rosiglitazone Early vs. SULphonylurea Titration (RESULT) study.
- Percutaneous transluminal angioplasty in severe diabetic foot ischemia: outcomes and prognostic factors.
- Antiatherogenic effects of angiotensin receptor antagonism in mild renal dysfunction.
- A novel receptor activator of NF-kappaB (RANK) cytoplasmic motif plays an essential role in osteoclastogenesis by committing macrophages to the osteoclast lineage.
- Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: a randomized controlled trial.
- Urinary connective tissue growth factor excretion correlates with clinical markers of renal disease in a large population of type 1 diabetic patients with diabetic nephropathy.
- A randomized comparison of pioglitazone to inhibit restenosis after coronary stenting in patients with type 2 diabetes.
- Impaired coronary endothelium-dependent vasodilation is associated with microalbuminuria in patients with type 2 diabetes and angiographically normal coronary arteries.
- Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin.
- Immune responses to an encapsulated allogeneic islet beta-cell line in diabetic NOD mice.
- Novel, potent P2-P3 pyrrolidine derivatives of ketoamide-based cathepsin K inhibitors.
- Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1.
- Dehydroepiandrosterone increases beta-cell mass and improves the glucose-induced insulin secretion by pancreatic islets from aged rats.
- 3D-QSAR and docking studies of aldehyde inhibitors of human cathepsin K.
- Comparative safety of atorvastatin 80 mg versus 10 mg derived from analysis of 49 completed trials in 14,236 patients.
- AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes.
- Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
- Adipose tissue proadipogenic redox changes in obesity.
- Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells.
- Contribution of adipocyte-derived factors to beta-cell dysfunction in diabetes.
- Indole-glucosides as novel sodium glucose co-transporter 2 (SGLT2) inhibitors. Part 2.
- Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor.
- The network of glucokinase-expressing cells in glucose homeostasis and the potential of glucokinase activators for diabetes therapy.
- Y2Y4 receptor double knockout protects against obesity due to a high-fat diet or Y1 receptor deficiency in mice.
- Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse.
- Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes.
- Glibenclamide treatment recruits beta-cell subpopulation into elevated and sustained basal insulin synthetic activity.
- Effect of combined antisense oligonucleotides against high-glucose- and diabetes-induced overexpression of extracellular matrix components and increased vascular permeability.
- Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model.
- The thromboxane receptor antagonist S18886 attenuates renal oxidant stress and proteinuria in diabetic apolipoprotein E-deficient mice.
- Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells.
- Transforming growth factor-beta and natural killer T-cells are involved in the protective effect of a bacterial extract on type 1 diabetes.
- Effects of hyperglycemia and hyperinsulinemia on circulating tissue factor procoagulant activity and platelet CD40 ligand.
- Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy.
- Muraglitazar, a novel dual (alpha/gamma) peroxisome proliferator-activated receptor activator, improves diabetes and other metabolic abnormalities and preserves beta-cell function in db/db mice.
- Does obesity induce resistance to the long-term cardiovascular and metabolic actions of melanocortin 3/4 receptor activation?
- Synergistic acceleration of arterial stiffening in the presence of raised blood pressure and raised plasma glucose.
- Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines.
- Design and synthesis of potent and subtype-selective PPARalpha agonists.
- Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients.
- Metformin inhibits proinflammatory responses and nuclear factor-kappaB in human vascular wall cells.
- Interleukin-1 receptor antagonist is upregulated during diet-induced obesity and regulates insulin sensitivity in rodents.
- Palm glucose readings compared with fingertip readings under steady and dynamic glycemic conditions, using the OneTouch Ultra Blood Glucose Monitoring System.
- Description and preliminary evaluation of a Multiagent Intelligent Dosing System (MAIDS) to manage combination insulin-oral agent therapy in type 2 diabetes.
- Blood glucose-lowering activity of a hyaluronan-insulin complex after oral administration to rats with diabetes.
- Discovery and optimization of a novel series of liver X receptor-alpha agonists.
- Passive immunization with monoclonal IgM antibodies against phosphorylcholine reduces accelerated vein graft atherosclerosis in apolipoprotein E-null mice.
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