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- Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice.
- Serum free Fatty acids and glucose metabolism, insulin resistance in schizophrenia with chronic antipsychotics.
- Synthesis and biological evaluation of lisofylline (LSF) analogs as a potential treatment for Type 1 diabetes.
- Synthesis and pharmacological activities of xanthone derivatives as alpha-glucosidase inhibitors.
- Antihypertensive effect of ragaglitazar: a novel PPARalpha and gamma dual activator.
- Adiponectin replenishment ameliorates obesity-related hypertension.
- The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis.
- FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity.
- Nonhormonal therapies for menopausal hot flashes: systematic review and meta-analysis.
- Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients.
- The PPARalpha ligand fenofibrate: meeting multiple targets in diabetic nephropathy.
- PPARalpha agonist fenofibrate improves diabetic nephropathy in db/db mice.
- Aggressive antihypertensive strategies based on hydrochlorothiazide, candesartan or lisinopril decrease left ventricular mass and improve arterial compliance in patients with type II diabetes mellitus and hypertension.
- Ciliary neurotrophic factor suppresses hypothalamic AMP-kinase signaling in leptin-resistant obese mice.
- Lipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.
- Synthesis and SAR of novel histamine H3 receptor antagonists.
- Effects of YM218, a nonpeptide vasopressin V(1A) receptor-selective antagonist, on vasopressin-induced growth responses in human mesangial cells.
- Design of cyclic peptides with agonist activity at melanocortin receptor-4.
- Effect of atorvastatin on the recurrence rates of atrial fibrillation after electrical cardioversion.
- A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss.
- Antinociceptive efficacy of lacosamide in a rat model for painful diabetic neuropathy.
- A selective peroxisome proliferator-activated receptor gamma modulator with distinct fat cell regulation properties.
- Impaired small-conductance Ca2+-activated K+ channel-dependent EDHF responses in Type II diabetic ZDF rats.
- The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.
- Altered calcium handling is an early sign of streptozotocin-induced diabetic cardiomyopathy.
- Effects of statins on the adipocyte maturation and expression of glucose transporter 4 (SLC2A4): implications in glycaemic control.
- Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.
- Altered bone and mineral metabolism in patients receiving imatinib mesylate.
- Do the metabolic effects of beta blockers make them leading or supporting antihypertensive agents in the treatment of hypertension?
- Shortened onset of action of antidepressants in major depression using acetylsalicylic acid augmentation: a pilot open-label study.
- Synthesis and structure-activity relationships of piperidine-based melanin-concentrating hormone receptor 1 antagonists.
- Design and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists.
- Developing a head for energy sensing: AMP-activated protein kinase as a multifunctional metabolic sensor in the brain.
- Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo.
- Hypothalamic mTOR signaling regulates food intake.
- Antagonism of peroxisome proliferator-activated receptor gamma prevents high-fat diet-induced obesity in vivo.
- Privileged structure based ligands for melanocortin receptors--4,4-disubstituted piperidine derivatives.
- Design, synthesis, and SAR studies on a series of 2-pyridinylpiperazines as potent antagonists of the melanocortin-4 receptor.
- Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.
- An orally active cathepsin K inhibitor, furan-2-carboxylic acid, 1-{1-[4-fluoro-2-(2-oxo-pyrrolidin-1-yl)-phenyl]-3-oxo-piperidin-4-ylcarbamoyl}-cyclohexyl)-amide (OST-4077), inhibits osteoclast activity in vitro and bone loss in ovariectomized rats.
- Reversal of diabetes by pancreatic islet transplantation into a subcutaneous, neovascularized device.
- Chronic administration of olanzapine induces metabolic and food intake alterations: a mouse model of the atypical antipsychotic-associated adverse effects.
- In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging.
- Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis.
- Cardiovascular function in a rat model of diet-induced obesity.
- Onset of type 1 diabetes mellitus during peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C.
- Cardioprotective effects of atrasentan, an endothelin-A receptor antagonist, but not of nitric oxide in diabetic mice with myocyte-specific overexpression of endothelial nitric oxide synthase.
- Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules.
- Efficacy and safety of topiramate in combination with metformin in the treatment of obese subjects with type 2 diabetes: a randomized, double-blind, placebo-controlled study.
- Deficiency of carbohydrate-activated transcription factor ChREBP prevents obesity and improves plasma glucose control in leptin-deficient (ob/ob) mice.
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