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- Characterization of diabetic nephropathy in a transgenic model of hypoinsulinemic diabetes.
- Obesity and risk of venous thromboembolism among postmenopausal women: differential impact of hormone therapy by route of estrogen administration. The ESTHER Study.
- SIM1 overexpression partially rescues agouti yellow and diet-induced obesity by normalizing food intake.
- Longitudinal noninvasive PET-based beta cell mass estimates in a spontaneous diabetes rat model.
- Peroxisome proliferator-activated receptor delta (PPARdelta), a novel target site for drug discovery in metabolic syndrome.
- Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats.
- Intravenously administered short interfering RNA accumulates in the kidney and selectively suppresses gene function in renal proximal tubules.
- Direct adenoviral transfer of bone morphogenetic protein-2 cDNA enhances fracture healing in osteoporotic sheep.
- Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice.
- The effect of statins on urinary albumin excretion and glomerular filtration rate: results from both a randomized clinical trial and an observational cohort study.
- PPAR-alpha and -gamma agonists attenuate diabetic kidney disease in the apolipoprotein E knockout mouse.
- Evaluation of the safety and pharmacodynamics of Hematide, a novel erythropoietic agent, in a phase 1, double-blind, placebo-controlled, dose-escalation study in healthy volunteers.
- Effects of obesity on lipid-lowering, anti-inflammatory, and antiatherosclerotic benefits of atorvastatin or pravastatin in patients with coronary artery disease (from the REVERSAL Study).
- An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy.
- Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C.
- Effects of NO-1886 on inflammation-associated cytokines in high-fat/high-sucrose/high-cholesterol diet-fed miniature pigs.
- Amino substituted analogs of 1-phenyl-3-phenylimino-2-indolones with potent galanin Gal3 receptor binding affinity and improved solubility.
- Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction.
- Reversal of type 1 diabetes by engineering a glucose sensor in skeletal muscle.
- Metallothionein and catalase sensitize to diabetes in nonobese diabetic mice: reactive oxygen species may have a protective role in pancreatic beta-cells.
- Peroxisome proliferator-activated receptor alpha improves pancreatic adaptation to insulin resistance in obese mice and reduces lipotoxicity in human islets.
- Thiazolidinediones ameliorate diabetic nephropathy via cell cycle-dependent mechanisms.
- Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy.
- Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes.
- Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.
- A 26-week, randomized, parallel, treat-to-target trial comparing insulin detemir with NPH insulin as add-on therapy to oral glucose-lowering drugs in insulin-naive people with type 2 diabetes.
- An open, randomized, parallel-group study to compare the efficacy and safety profile of inhaled human insulin (Exubera) with metformin as adjunctive therapy in patients with type 2 diabetes poorly controlled on a sulfonylurea.
- Prevalence and risk factors for urinary incontinence in women with type 2 diabetes and impaired fasting glucose: findings from the National Health and Nutrition Examination Survey (NHANES) 2001-2002.
- Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats.
- Downregulation of angiogenic factors and their downstream target molecules affects the deterioration of erectile function in a rat model of hypercholesterolemia.
- Antiobesity effects of the novel in vivo neutral cannabinoid receptor antagonist 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole--LH 21.
- Daily nasal spray of hPTH(1-34) for 3 months increases bone mass in osteoporotic subjects: a pilot study.
- Fluoxetine after weight restoration in anorexia nervosa: a randomized controlled trial.
- Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity.
- Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis.
- TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.
- Activation of dopamine D2 receptors simultaneously ameliorates various metabolic features of obese women.
- 4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17beta-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate.
- Monocyclic thiophenes as protein tyrosine phosphatase 1B inhibitors: capturing interactions with Asp48.
- Hippocampal neuropathology of diabetes mellitus is relieved by estrogen treatment.
- Tetraspanin CD9 regulates osteoclastogenesis via regulation of p44/42 MAPK activity.
- Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
- Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity.
- The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication.
- ATP and norepinephrine contributions to sympathetic vasoconstriction of tail artery are altered in streptozotocin-diabetic rats.
- Prevalence of the metabolic syndrome among patients receiving clozapine.
- Atypical antipsychotic drugs directly impair insulin action in adipocytes: effects on glucose transport, lipogenesis, and antilipolysis.
- Inhibition of dopamine and norepinephrine reuptake produces additive effects on energy balance in lean and obese mice.
- Meta-analysis: the effect of statins on albuminuria.
- Role of estrogens in inflammatory response: expression of estrogen receptors in peritoneal fluid macrophages from endometriosis.
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