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- Hypertension and antihypertensive treatment of diabetic nephropathy.
- Telmisartan inhibits AGE-induced C-reactive protein production through downregulation of the receptor for AGE via peroxisome proliferator-activated receptor-gamma activation.
- Altered PPARgamma expression and activation after transient focal ischemia in rats.
- Tetrahydroisoquinoline PPARgamma agonists: design of novel, highly selective non-TZD antihyperglycemic agents.
- Synthesis and evaluation of aminomethyl dihydrocinnamates as a new class of PPAR ligands.
- Critical role of the epithelial Ca2+ channel TRPV5 in active Ca2+ reabsorption as revealed by TRPV5/calbindin-D28K knockout mice.
- Treatment of morbid obesity by intraparietogastric administration of botulinum toxin: a randomized, double-blind, controlled study.
- Tissue kallikrein stimulates Ca(2+) reabsorption via PKC-dependent plasma membrane accumulation of TRPV5.
- Antidiabetic effect of a novel non-thiazolidinedione PPAR gamma/alpha agonist on ob/ob mice.
- Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance.
- Estrogen deficiency decreases ischemic tolerance in the aged rat heart: Roles of PKCdelta, PKCepsilon, Akt, and GSK3beta.
- The RXR agonist bexarotene improves cholesterol homeostasis and inhibits atherosclerosis progression in a mouse model of mixed dyslipidemia.
- Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol.
- Capecitabine improves cancer cachexia and normalizes IL-6 and PTHrP levels in mouse cancer cachexia models.
- Renin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes: a subanalysis of Japanese patients from the RENAAL study.
- Structure-based de novo design, synthesis, and biological evaluation of the indole-based PPARgamma ligands (I).
- Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors.
- Probing the physicochemical and structural requirements for glycogen synthase kinase-3alpha inhibition: 2D-QSAR for 3-anilino-4-phenylmaleimides.
- Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
- Novel roles of the IGF-IGFBP axis in etiopathophysiology of diabetic nephropathy.
- Primary prevention of cardiovascular disease with pravastatin in Japan (MEGA Study): a prospective randomised controlled trial.
- Intravitreal bevacizumab (Avastin) in the treatment of proliferative diabetic retinopathy.
- A pilot study of multiple intravitreal injections of ranibizumab in patients with center-involving clinically significant diabetic macular edema.
- Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor.
- Genome-wide analysis of estrogen receptor binding sites.
- Modest but sustained increase of serum high density lipoprotein cholesterol levels in patients with inflammatory arthritides treated with infliximab.
- Duloxetine for patients with diabetic peripheral neuropathic pain: a 6-month open-label safety study.
- Biochemical mechanism of insulin sensitization, lipid modulation and anti-atherogenic potential of PPAR alpha/gamma dual agonist: Ragaglitazar.
- High-fat diet in low-dose-streptozotocin-treated heminephrectomized rats induces all features of human type 2 diabetic nephropathy: a new rat model of diabetic nephropathy.
- Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer.
- Licofelone, a balanced inhibitor of cyclooxygenase and 5-lipoxygenase, reduces inflammation in a rabbit model of atherosclerosis.
- Dendritic cells expressing transgenic galectin-1 delay onset of autoimmune diabetes in mice.
- Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme.
- A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
- Inhibiting albumin glycation attenuates dysregulation of VEGFR-1 and collagen IV subchain production and the development of renal insufficiency.
- Protective effect of simvastatin and VULM 1457 in ischaemic-reperfused myocardium of the diabetic-hypercholesterolemic rats.
- Imatinib mesylate (Gleevec) protects against streptozotocin-induced diabetes and islet cell death in vitro.
- Alloxan-induced diabetes reduces sarcolemmal Na+-K+ pump function in rabbit ventricular myocytes.
- Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats.
- Kisspeptins are novel potent vasoconstrictors in humans, with a discrete localization of their receptor, G protein-coupled receptor 54, to atherosclerosis-prone vessels.
- Soluble guanylyl cyclase activation with HMR1766 attenuates platelet activation in diabetic rats.
- Gluconeogenesis: re-evaluating the FOXO1-PGC-1alpha connection.
- Reduced left ventricular mass after treatment of obese patients with sibutramine: An echocardiographic multicentre study.
- Simvastatin improves left ventricular function after myocardial infarction in hypercholesterolemic rabbits by anti-inflammatory effects.
- An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism.
- Insulin resistance, diabetes, hypertension, and renin-angiotensin system inhibition: reducing risk for cardiovascular disease.
- Amlodipine versus angiotensin II receptor blocker; control of blood pressure evaluation trial in diabetics (ADVANCED-J).
- Hyperlipidemic mice present enhanced catabolism and higher mitochondrial ATP-sensitive K+ channel activity.
- Neuromedin U receptor 2-deficient mice display differential responses in sensory perception, stress, and feeding.
- Absence of malonyl coenzyme A decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury.
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