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- Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects.
- Azelnidipine down-regulates renal angiotensin-converting enzyme and mineralocorticoid receptor mRNA in diabetic hypertensive rats.
- Angiotensin II type 1 receptor blocker attenuates exacerbated left ventricular remodeling and failure in diabetes-associated myocardial infarction.
- Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
- Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes.
- Structural basis for the structure-activity relationships of peroxisome proliferator-activated receptor agonists.
- Biologically active lipids promote trafficking and membrane association of Rac1 in insulin-secreting INS 832/13 cells.
- Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes.
- Beneficial action of 2,4,4-trimethyl-3-(15-hydroxypentadecyl)-2-cyclohexen-1-one, a novel long-chain fatty alcohol, on diabetic hypoalgesia and neuropathic hyperalgesia.
- Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes.
- Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study.
- Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy.
- Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice.
- The MC4 receptor and control of appetite.
- SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes.
- On the processing of proghrelin to ghrelin.
- Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle.
- Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level.
- Rosuvastatin increases alpha-1 microglobulin urinary excretion in patients with primary dyslipidemia.
- The increased angiotensin II (type 1) receptor density in myocardium of type 2 diabetic patients is prevented by blockade of the renin-angiotensin system.
- Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice.
- Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice.
- TLR4 links innate immunity and fatty acid-induced insulin resistance.
- The prevalence of co-morbid depression in adults with Type 2 diabetes: a systematic review and meta-analysis.
- Coronary calcification, homocysteine, C-reactive protein and the metabolic syndrome in Type 2 diabetes: the Prospective Evaluation of Diabetic Ischaemic Heart Disease by Coronary Tomography (PREDICT) Study.
- Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability.
- Thiazolidinediones and the risk of edema: a meta-analysis.
- (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
- Simvastatin improves the attenuated heart rate recovery of type 2 diabetics.
- Hemodynamic effects of potent and selective JNK inhibitors in anesthetized rats: implication for targeting protein kinases in metabolic diseases.
- Identification of selective neuropeptide Y2 peptide agonists.
- A randomized controlled trial of duloxetine in diabetic peripheral neuropathic pain.
- Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite.
- Benefits of candesartan on arterial and renal damage of non-diabetic hypertensive patients treated with calcium channel blockers.
- Discovery of ((4R,5S)-5-amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
- Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.
- Deletion of the serotonin 2c receptor from transgenic mice overexpressing leptin does not affect their lipodystrophy but exacerbates their diet-induced obesity.
- Metabolic syndrome and its components as predictors of all-cause mortality and coronary heart disease in type 2 diabetic patients.
- Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?
- Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy.
- Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.
- Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice.
- Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents.
- Glucocorticoid-induced tumour necrosis factor receptor family related protein (GITR) mediates inflammatory activation of macrophages that can destabilize atherosclerotic plaques.
- Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.
- Acylated and unacylated ghrelin promote proliferation and inhibit apoptosis of pancreatic beta-cells and human islets: involvement of 3',5'-cyclic adenosine monophosphate/protein kinase A, extracellular signal-regulated kinase 1/2, and phosphatidyl inositol 3-Kinase/Akt signaling.
- Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice.
- Thiol-related genes in diabetic complications: a novel protective role for endogenous thioredoxin 2.
- Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
- Examination of lower targets for low-density lipoprotein cholesterol and blood pressure in diabetes--the Stop Atherosclerosis in Native Diabetics Study (SANDS).
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