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- Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.
- Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth.
- Renin-angiotensin blockade attenuates cardiac myofibrillar remodelling in chronic diabetes.
- Effect of amlodipine-atorvastatin combination on fibrinolysis in hypertensive hypercholesterolemic patients with insulin resistance.
- Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia.
- Antiproteinuric effect of candesartan cilexetil in Japanese subjects with type 2 diabetes and nephropathy.
- Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial.
- Catalytic domain crystal structure of protein kinase C-theta (PKCtheta).
- Use of beta-blockers and risk of fractures.
- Nonpeptidic, noncovalent inhibitors of the cysteine protease cathepsin S.
- Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis.
- Exploring the binding mode of semicarbazide-sensitive amine oxidase/VAP-1: identification of novel substrates with insulin-like activity.
- Pharmacoeconomic challenges in the management of diabetic nephropathy.
- Intracorporal injection of hSlo cDNA restores erectile capacity in STZ-diabetic F-344 rats in vivo.
- PKC-theta knockout mice are protected from fat-induced insulin resistance.
- A pilot study on safety and pharmacokinetics of infliximab for the cancer anorexia/weight loss syndrome in non-small-cell lung cancer patients.
- Comparison of frequency of insulin resistance after coronary stenting in patients with type 2 diabetes mellitus with versus without coronary restenosis.
- Anticachectic effects of formoterol: a drug for potential treatment of muscle wasting.
- Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.
- 4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists.
- Potent and selective proline derived dipeptidyl peptidase IV inhibitors.
- Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
- Synthesis and in vitro evaluation of (S)-2-([11C]methoxy)-4-[3-methyl-1-(2-piperidine-1-yl-phenyl)-butyl-carbamoyl]-benzoic acid ([11C]methoxy-repaglinide): a potential beta-cell imaging agent.
- Novel isoxazole carboxamides as growth hormone secretagogue receptor (GHS-R) antagonists.
- Piperidine-containing beta-arylpropionic acids as potent antagonists of alphavbeta3/alphavbeta5 integrins.
- Suppression of cancer cachexia by 20S,21-epoxy-resibufogenin-3-acetate-a novel nonpeptide IL-6 receptor antagonist.
- Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.
- Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study.
- Novel RGD-like molecules based on the tyrosine template: design, synthesis, and biological evaluation on isolated integrins alphaVbeta3/alphaIIbbeta3 and in cellular adhesion tests.
- The impact of DeltaG on the oral bioavailability of low bioavailable therapeutic agents.
- Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
- Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide.
- Meta-analysis of the efficacy of alendronate for the prevention of hip fractures in postmenopausal women.
- Using yeast to screen for inhibitors of protein tyrosine phosphatase 1B.
- Insulin glulisine provides improved glycemic control in patients with type 2 diabetes.
- Fluvastatin enhances the inhibitory effects of a selective AT1 receptor blocker, valsartan, on atherosclerosis.
- Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy.
- Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice.
- Bis[3-(4'-substituted phenyl)prop-2-ene]disulfides as a new class of antihyperlipidemic compounds.
- 17beta-Estradiol replacement improves renal function and pathology associated with diabetic nephropathy.
- Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
- Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K.
- Effect of fluvastatin on renal end points in the Assessment of Lescol in Renal Transplant (ALERT) trial.
- Effects of infliximab treatment on insulin resistance in patients with rheumatoid arthritis and ankylosing spondylitis.
- Inhibition of endogenous leptin protects mice from arterial and venous thrombosis.
- Effects of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists on mortality and renal outcomes in diabetic nephropathy: systematic review.
- A novel approach to treatment of hypertension in diabetic patients - a multicenter, double-blind, randomized study comparing the efficacy of combination therapy of Eprosartan versus Ramipril with low-dose Hydrochlorothiazide and Moxonidine on blood pressure levels in patients with hypertension and associated diabetes mellitus type 2 - rationale and design [ISRCTN55725285].
- The effect of irbesartan in reducing cardiovascular risk in hypertensive type 2 diabetic patients: an observational study in 16,600 patients in primary care.
- Hepatic glucagon receptor binding and glucose-lowering in vivo by peptidyl and non-peptidyl glucagon receptor antagonists.
- Safety of rosuvastatin.
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