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- The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes.
- Hyperinsulinaemia is associated with increased long-term mortality following acute myocardial infarction in non-diabetic patients.
- Human immunodeficiency virus protease inhibitors accumulate into cultured human adipocytes and alter expression of adipocytokines.
- Crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets.
- Dual effect of angiotensin-converting enzyme inhibition on angiogenesis in type 1 diabetic mice.
- Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins.
- Metabolic effects of carvedilol vs metoprolol in patients with type 2 diabetes mellitus and hypertension: a randomized controlled trial.
- The metabolic syndrome, inflammation, and risk of cognitive decline.
- Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.
- Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.
- Building predictive models for protein tyrosine phosphatase 1B inhibitors based on discriminating structural features by reassembling medicinal chemistry building blocks.
- Ligand discovery using small molecule microarrays.
- Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus.
- Prevalence of coronary heart disease and carotid arterial thickening in patients with the metabolic syndrome (The ARIC Study).
- 6-[2-(adamantylidene)-hydroxybenzoxazole]-O-sulfamate, a steroid sulfatase inhibitor for the treatment of androgen- and estrogen-dependent diseases.
- Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.
- Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives.
- Insulin resistance as a contributor to myocardial ischaemia independent of obstructive coronary atheroma: a role for insulin sensitisation?
- Effect of retinoic acid in experimental diabetic nephropathy.
- trans-Beta-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases.
- Furosin, an ellagitannin, suppresses RANKL-induced osteoclast differentiation and function through inhibition of MAP kinase activation and actin ring formation.
- Roles of ATP-sensitive K+ channels as metabolic sensors: studies of Kir6.x null mice.
- Decreased sarcoplasmic reticulum activity and contractility in diabetic db/db mouse heart.
- Development of late-stage diabetic nephropathy in OVE26 diabetic mice.
- Obesity and the risk of new-onset atrial fibrillation.
- Trends in cardiovascular complications of diabetes.
- Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes.
- Two-year statin therapy does not alter the progression of intima-media thickness in patients with type 2 diabetes without manifest cardiovascular disease.
- Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trial.
- Antidiabetic and adipogenic properties in a newly synthesized thiazolidine derivative, FPFS-410.
- Inhibition of triglyceride synthesis as a treatment strategy for obesity: lessons from DGAT1-deficient mice.
- Insulin resistance contributes to aberrant stress responses in the Tg2576 mouse model of Alzheimer's disease.
- Artificial cell microcapsule for oral delivery of live bacterial cells for therapy: design, preparation, and in-vitro characterization.
- Obesity-related leptin regulates Alzheimer's Abeta.
- The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro.
- The effects of HIV protease inhibitors atazanavir and lopinavir/ritonavir on insulin sensitivity in HIV-seronegative healthy adults.
- The effect of PDE5 inhibition on the erectile function in streptozotocin-induced diabetic rats.
- High prevalence of peripheral arterial disease and low treatment rates in elderly primary care patients with diabetes.
- Continuum of renoprotection with losartan at all stages of type 2 diabetic nephropathy: a post hoc analysis of the RENAAL trial results.
- Efficacy and safety of pioglitazone versus metformin in patients with type 2 diabetes mellitus: a double-blind, randomized trial.
- Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist.
- Pharmacologically regulated regeneration of functional human pancreatic islets.
- Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.
- Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha).
- Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice.
- Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention.
- NOD mice have a severely impaired ability to recruit leukocytes into sites of inflammation.
- Effect of intermittent administration of human parathyroid hormone on bone mineral density and arthritis in rats with collagen-induced arthritis.
- Use of the Continuous Glucose Monitoring System to guide therapy in patients with insulin-treated diabetes: a randomized controlled trial.
- The in vitro differentiation of rat neural stem cells into an insulin-expressing phenotype.
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