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- Discovery of corticotropin releasing factor 2 receptor selective sauvagine analogues for treatment of skeletal muscle atrophy.
- Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease.
- Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion.
- A novel calcium-sensing receptor antagonist transiently stimulates parathyroid hormone secretion in vivo.
- 1,25-Dihydroxyvitamin D3 modulates expression of chemokines and cytokines in pancreatic islets: implications for prevention of diabetes in nonobese diabetic mice.
- Role of meltrin {alpha} (ADAM12) in obesity induced by high- fat diet.
- Impaired endothelium-dependent responses and enhanced influence of Rho-kinase in cerebral arterioles in type II diabetes.
- Recombinant adeno-associated virus vector expressing angiostatin inhibits preretinal neovascularization in adult rats.
- Results of a randomized, double-blind, placebo-controlled study administering glimepiride to patients with type 2 diabetes mellitus inadequately controlled with rosiglitazone monotherapy.
- Nur77 regulates lipolysis in skeletal muscle cells. Evidence for cross-talk between the beta-adrenergic and an orphan nuclear hormone receptor pathway.
- Association between hormone replacement therapy and subsequent stroke: a meta-analysis.
- Phase II study of transdermal estradiol in androgen-independent prostate carcinoma.
- The anti-obesity effect of rimonabant is associated with an improved serum lipid profile.
- Insulin detemir used in basal-bolus therapy in people with type 1 diabetes is associated with a lower risk of nocturnal hypoglycaemia and less weight gain over 12 months in comparison to NPH insulin.
- Efficacy and safety of ezetimibe co-administered with simvastatin in thiazolidinedione-treated type 2 diabetic patients.
- Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.
- Statin use and survival outcomes in elderly patients with heart failure.
- Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
- Trends and determinants of antiresorptive drug use for osteoporosis among elderly women.
- Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats.
- Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease.
- Lipodystrophy in patients with HIV-1 infection: effect of stopping protease inhibitors on TNF-alpha and TNF-receptor levels, and on metabolic parameters.
- Antiretroviral drugs with adverse effects on adipocyte lipid metabolism and survival alter the expression and secretion of proinflammatory cytokines and adiponectin in vitro.
- Prevalence of the metabolic syndrome using the Third Report of the National Cholesterol Educational Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATP III) and the modified ATP III definitions for Japanese and Mongolians.
- Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors.
- Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human beta3-adrenergic receptor agonists with high cell permeability.
- The vascular effects of doxazosin in hypertension complicated by metabolic syndrome.
- Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity.
- Estrogenic restoration of functional pancreatic islet cytoarchitecture in diabetes (db/db) mutant C57BL/KsJ mice: relationship to estradiol localization, systemic glycemia, and persistent hyperinsulinemia.
- Double-blind, placebo-controlled trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
- Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats.
- Reduction of PTP1B by RNAi upregulates the activity of insulin controlled fatty acid synthase promoter.
- The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance.
- A new drug carrier, Nalpha-deoxycholyl-L: -lysyl-methylester, for enhancing insulin absorption in the intestine.
- Development of an automated protein-tyrosine phosphatase 1B inhibition assay and the screening of putative insulin-enhancing vanadium(IV) and zinc(II) complexes.
- Identification of 2-(4-benzyloxyphenyl)-N- [1-(2-pyrrolidin-1-yl-ethyl)-1H-indazol-6-yl]acetamide, an orally efficacious melanin-concentrating hormone receptor 1 antagonist for the treatment of obesity.
- Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
- Endocrinological properties of two novel nonsteroidal progesterone receptor modulators, CP8816 and CP8863.
- Functional selectivity of melanocortin 4 receptor peptide and nonpeptide agonists: evidence for ligand-specific conformational states.
- Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
- Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis.
- Design, synthesis, and biological activity of novel PPARgamma ligands based on rosiglitazone and 15d-PGJ2.
- Novel and potent NPY5 receptor antagonists derived from virtual screening and iterative parallel chemistry design.
- Melanocortin subtype-4 receptor agonists containing a piperazine core with substituted aryl sulfonamides.
- Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation.
- Improvement of metabolic state in an animal model of nutrition-dependent type 2 diabetes following treatment with S 23521, a new glucagon-like peptide 1 (GLP-1) analogue.
- The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis.
- Association between a variation in the phosphodiesterase 4D gene and bone mineral density.
- Insulin sensitivity and endothelial function in hypertension: a comparison of temocapril and candesartan.
- An insulin-response element-binding protein that ameliorates hyperglycemia in diabetes.
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