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- Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats.
- Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia.
- BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures.
- IKK mediates ischemia-induced neuronal death.
- K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons.
- Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
- NMDA neuroprotection against a phosphatidylinositol-3 kinase inhibitor, LY294002 by NR2B-mediated suppression of glycogen synthase kinase-3beta-induced apoptosis.
- Docosahexaenoic acid prevents neuronal apoptosis induced by soluble amyloid-beta oligomers.
- In vitro characterization of a gamma-secretase radiotracer in mammalian brain.
- Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia-induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue.
- Caspase inhibition therapy abolishes brain trauma-induced increases in Abeta peptide: implications for clinical outcome.
- Glucosamine abrogates the acute phase of experimental autoimmune encephalomyelitis by induction of Th2 response.
- Protein kinase Ctheta controls Th1 cells in experimental autoimmune encephalomyelitis.
- N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.
- Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds.
- Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.
- 9-Cis-retinoic acid suppresses inflammatory responses of microglia and astrocytes.
- Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
- Peripheral hyperinsulinemia promotes tau phosphorylation in vivo.
- Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease.
- Upregulation of the voltage-gated sodium channel beta2 subunit in neuropathic pain models: characterization of expression in injured and non-injured primary sensory neurons.
- An epoxide hydrolase inhibitor, 12-(3-adamantan-1-yl-ureido)dodecanoic acid (AUDA), reduces ischemic cerebral infarct size in stroke-prone spontaneously hypertensive rats.
- Effect of long-term mild hypothermia or short-term mild hypothermia on outcome of patients with severe traumatic brain injury.
- XIAP-mediated neuroprotection in retinal ischemia.
- Tissue inhibitor of metalloproteinases-1 (TIMP-1) modulates neuronal death, axonal plasticity, and learning and memory.
- Lentivector-mediated delivery of GDNF protects complex motor functions relevant to human Parkinsonism in a rat lesion model.
- Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
- Do bone marrow stromal cells proliferate after transplantation into mice cerebral infarct?--a double labeling study.
- Valproic acid-mediated Hsp70 induction and anti-apoptotic neuroprotection in SH-SY5Y cells.
- Syntheses and evaluation of fluorinated conformationally restricted analogues of GABA as potential inhibitors of GABA aminotransferase.
- Regulation of p53 by activated protein kinase C-delta during nitric oxide-induced dopaminergic cell death.
- Risperidone for psychosis of Alzheimer's disease and mixed dementia: results of a double-blind, placebo-controlled trial.
- Treatment of behavioural, cognitive and circadian rest-activity cycle disturbances in Alzheimer's disease: haloperidol vs. quetiapine.
- Detailed pharmacological characterization of GT-2331 for the rat histamine H3 receptor.
- Neuroprotection by tetramethylpyrazine against ischemic brain injury in rats.
- Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats.
- Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor.
- A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease.
- Effects of dyskinesias in Parkinson's disease on quality of life and health-related costs: a prospective European study.
- alpha7 Nicotinic acetylcholine receptor as a target to rescue deficit in hippocampal LTP induction in beta-amyloid infused rats.
- Protective effects of nicergoline against neuronal cell death induced by activated microglia and astrocytes.
- Design, synthesis, and structure-activity relationship of novel thiophene derivatives for beta-amyloid plaque imaging.
- Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone.
- Neuronal cell death induced by cystatin C in vivo and in cultured human CNS neurons is inhibited with cathepsin B.
- FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats.
- Neuroprotective effects of the agonist of metabotropic glutamate receptors ABHxD-I in two animal models of cerebral ischaemia.
- An inverse agonist selective for alpha5 subunit-containing GABAA receptors enhances cognition.
- Reduction in brain infarction by augmentation of central histaminergic activity in rats.
- Neuroprotection against ischaemic brain injury by a GluR6-9c peptide containing the TAT protein transduction sequence.
- Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis.