Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloid.
- 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors.
- Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
- Neuroprotection of nicotiflorin in permanent focal cerebral ischemia and in neuronal cultures.
- Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons.
- Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profile.
- Vagus nerve stimulation in patients with Alzheimer's disease: Additional follow-up results of a pilot study through 1 year.
- Inhibition of secreted phospholipase A2 by neuron survival and anti-inflammatory peptide CHEC-9.
- Secreted phospholipase A2 activity in experimental autoimmune encephalomyelitis and multiple sclerosis.
- A phase I trial of an interleukin-12/23 monoclonal antibody in relapsing multiple sclerosis.
- Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10.
- Increased soluble 4-1BB ligand (4-1BBL) levels in peripheral blood of patients with multiple sclerosis.
- Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease.
- Oral fingolimod (FTY720) for relapsing multiple sclerosis.
- Pranlukast, a cysteinyl leukotriene receptor 1 antagonist, protects mice against brain cold injury.
- Hepatocyte growth factor attenuates cerebral ischemia-induced increase in permeability of the blood-brain barrier and decreases in expression of tight junctional proteins in cerebral vessels.
- Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro.
- YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
- In vivo effects of mitoxantrone on the production of pro- and anti-inflammatory cytokines by peripheral blood mononuclear cells of secondary progressive multiple sclerosis patients.
- Activation of 5-HT4 receptors inhibits secretion of beta-amyloid peptides and increases neuronal survival.
- Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death.
- Kinase activity of mutant LRRK2 mediates neuronal toxicity.
- COPI-mediated retrograde transport is required for efficient gamma-secretase cleavage of the amyloid precursor protein.
- Nonviral gene transfer of hepatocyte growth factor attenuates neurologic injury after spinal cord ischemia in rabbits.
- Tails of the unexpected - an atypical receptor for the chemokine RANTES/CCL5 expressed in brain.
- Modulation of Abeta42 low-n oligomerization using a novel yeast reporter system.
- The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice.
- Effects of glatiramer acetate and interferon-beta on neurodegeneration in a model of multiple sclerosis: a comparative study.
- Design, synthesis, and biological evaluation of new 1,8-naphthyridin-4(1H)-on-3-carboxamide and quinolin-4(1H)-on-3-carboxamide derivatives as CB2 selective agonists.
- Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.
- Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies.
- Curcumin and dehydrozingerone derivatives: synthesis, radiolabeling, and evaluation for beta-amyloid plaque imaging.
- Heparin derivatives as inhibitors of BACE-1, the Alzheimer's beta-secretase, with reduced activity against factor Xa and other proteases.
- Altered PPARgamma expression and activation after transient focal ischemia in rats.
- Pain hypersensitivity in rats with experimental autoimmune neuritis, an animal model of human inflammatory demyelinating neuropathy.
- New multipotent tetracyclic tacrines with neuroprotective activity.
- Activation, internalization, and recycling of the serotonin 2A receptor by dopamine.
- BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology.
- Possible mechanisms of neurodegeneration in schizophrenia.
- R-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo-[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphtalenylmethanone (WIN-2) ameliorates experimental autoimmune encephalomyelitis and induces encephalitogenic T cell apoptosis: partial involvement of the CB(2) receptor.
- Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.
- A novel calpain inhibitor for the treatment of acute experimental autoimmune encephalomyelitis.
- Cholinesterase inhibitors: SAR and enzyme inhibitory activity of 3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones.
- Neuronal neprilysin overexpression is associated with attenuation of Abeta-related spatial memory deficit.
- The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors.
- Leukotriene D4 induces brain edema and enhances CysLT2 receptor-mediated aquaporin 4 expression.
- Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel.
- Improved regional cerebral blood flow is important for the protection seen in a mouse model of late phase ischemic preconditioning.
- Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton.
- CD4+CD25+FoxP3+ T lymphocytes fail to suppress myelin basic protein-induced proliferation in patients with multiple sclerosis.