Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Safety and efficacy of donepezil in African Americans with mild-to-moderate Alzheimer's disease.
- Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2.
- Neuroprotective interaction produced by xenon and dexmedetomidine on in vitro and in vivo neuronal injury models.
- Baicalein and 12/15-lipoxygenase in the ischemic brain.
- Synergistic protective effects of erythropoietin and olmesartan on ischemic stroke survival and post-stroke memory dysfunctions in the gerbil.
- Aldolase C/zebrin II is released to the extracellular space after stroke and inhibits the network activity of cortical neurons.
- Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis.
- The heat shock protein inhibitor KNK437 induces neurite outgrowth in PC12 cells.
- 2,6-Disubstituted N-arylsulfonyl piperidines as gamma-secretase inhibitors.
- IL-10 signaling is essential for 1,25-dihydroxyvitamin D3-mediated inhibition of experimental autoimmune encephalomyelitis.
- A mouse model for monitoring calpain activity under physiological and pathological conditions.
- Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles.
- Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes.
- Mitochondrial damage modulates alternative splicing in neuronal cells: implications for neurodegeneration.
- Therapeutic time window of neuroprotection by non-competitive AMPA antagonists in transient and permanent focal cerebral ischemia in rats.
- Synthesis and biological evaluation of novel T-type calcium channel blockers.
- Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction.
- Prevention and treatment of experimental autoimmune encephalomyelitis with recombinant adeno-associated virus-mediated alpha-melanocyte-stimulating hormone-transduced PLP139-151-specific T cells.
- Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.
- Characterization and restoration of altered inhibitory and excitatory control of micturition reflex in experimental autoimmune encephalomyelitis in rats.
- Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.
- Additional outcomes and subgroup analyses of NXY-059 for acute ischemic stroke in the SAINT I trial.
- SB-399885 is a potent, selective 5-HT6 receptor antagonist with cognitive enhancing properties in aged rat water maze and novel object recognition models.
- Synthesis and studies on antidepressant and anticonvulsant activities of some 3-(2-furyl)-pyrazoline derivatives.
- Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors.
- Diltiazem protects human NT-2 neurons against excitotoxic damage in a model of simulated ischemia.
- Differential effects of tumor necrosis factor-alpha co-administered with amyloid beta-peptide (25-35) on memory function and hippocampal damage in rat.
- Treating dopamimetic psychosis in Parkinson's disease: structured review and meta-analysis.
- Determining the critical nucleus and mechanism of fibril elongation of the Alzheimer's Abeta(1-40) peptide.
- Roles of voltage-dependent sodium channels in neuronal development, pain, and neurodegeneration.
- Impaired function and expression of P-glycoprotein in blood-brain barrier of streptozotocin-induced diabetic rats.
- Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists.
- 3D pharmacophore based virtual screening of T-type calcium channel blockers.
- Neuroprotectant FK506 inhibits glutamate-induced apoptosis of astrocytes in vitro and in vivo.
- Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor.
- Postischemic gene transfer of soluble Flt-1 protects against brain ischemia with marked attenuation of blood-brain barrier permeability.
- Erythropoietin-induced neurovascular protection, angiogenesis, and cerebral blood flow restoration after focal ischemia in mice.
- EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia.
- Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.
- Reinstatement of episodic-like memory in rats by neurokinin-1 receptor antagonism.
- Dysfunction of TGF-beta signaling in Alzheimer's disease.
- Microglia: a cellular vehicle for CNS gene therapy.
- Deficiency in neuronal TGF-beta signaling promotes neurodegeneration and Alzheimer's pathology.
- Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice.
- A Phase II study targeting amyloid-beta with 3APS in mild-to-moderate Alzheimer disease.
- Immunomodulation strategies for preventing vascular disease of the brain and heart: workshop summary.
- Granulocyte-colony-stimulating factor mobilizes bone marrow stem cells in patients with subacute ischemic stroke: the Stem cell Trial of recovery EnhanceMent after Stroke (STEMS) pilot randomized, controlled trial (ISRCTN 16784092).
- Therapeutic angiogenesis using novel vascular endothelial growth factor-E/human placental growth factor chimera genes.
- A single injection of D-amphetamine facilitates improvements in motor training following a focal cortical infarct in squirrel monkeys.
- A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells.