Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Complement-dependent P-selectin expression and injury following ischemic stroke.
- A high throughput fluorescent assay for measuring the activity of fatty acid amide hydrolase.
- Anti-apoptotic effect of granulocyte-colony stimulating factor after focal cerebral ischemia in the rat.
- A1 adenosine receptor-mediated modulation of neuronal ATP-sensitive K channels in rat substantia nigra.
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE.
- Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8.
- Inhibition of beta-amyloid fibrillization by directed evolution of a beta-sheet presenting miniature protein.
- A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2.
- Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity.
- Mitochondrial stress-induced dopamine efflux and neuronal damage by malonate involves the dopamine transporter.
- Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine.
- Design, synthesis, and biological evaluation of 1,3-dioxoisoindoline-5-carboxamide derivatives as T-type calcium channel blockers.
- Broad-spectrum effects of 4-aminopyridine to modulate amyloid beta1-42-induced cell signaling and functional responses in human microglia.
- Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.
- The vasohibin family: a negative regulatory system of angiogenesis genetically programmed in endothelial cells.
- Rater-blinded, prospective comparison: quetiapine versus clozapine for Parkinson's disease psychosis.
- Synthesis, nicotinic acetylcholine receptor binding, antinociceptive and seizure properties of methyllycaconitine analogs.
- Neuroglobin-overexpressing transgenic mice are resistant to cerebral and myocardial ischemia.
- The novel gamma secretase inhibitor N-[cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide (MRK-560) reduces amyloid plaque deposition without evidence of notch-related pathology in the Tg2576 mouse.
- A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord.
- Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts.
- fMRI study of episodic memory in relapsing-remitting MS: correlation with T2 lesion volume.
- The GuidAge study: methodological issues. A 5-year double-blind randomized trial of the efficacy of EGb 761 for prevention of Alzheimer disease in patients over 70 with a memory complaint.
- Marked prevention of ischemic brain injury by Neu2000, an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine.
- Cholesterol-depleting statin drugs protect postmitotically differentiated human neurons against ethanol- and human immunodeficiency virus type 1-induced oxidative stress in vitro.
- Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.
- Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord.
- Cysteinyl leukotriene receptors CysLT1 and CysLT2 are upregulated in acute neuronal injury after focal cerebral ischemia in mice.
- Darbepoetin alfa (Aranesp) improves recognition memory in adult rats that have sustained bilateral ventral hippocampal lesions as neonates or young adults.
- Lactoferrin ameliorates symptoms of experimental encephalomyelitis in Lewis rats.
- Olanzapine attenuates brain damage after focal cerebral ischemia in vivo.
- Cutting Edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta.
- CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis.
- A requirement for microglial TLR4 in leukocyte recruitment into brain in response to lipopolysaccharide.
- Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia.
- Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.
- Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
- Pharmacokinetics of the new antiepileptic and CNS drug RWJ-333369 following single and multiple dosing to humans.
- Monoclonal antibodies that target pathological assemblies of Abeta.
- A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activation.
- Blocking the apolipoprotein E/amyloid-beta interaction as a potential therapeutic approach for Alzheimer's disease.
- A double-blind, placebo-controlled trial of memantine in age-associated memory impairment (memantine in AAMI).
- Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors.
- 2-Aminotetraline derivative protects from ischemia/reperfusion brain injury with a broad therapeutic window.
- Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants.
- Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors.
- Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils.
- Adenosine A2A receptor blockade before striatal excitotoxic lesions prevents long term behavioural disturbances in the quinolinic rat model of Huntington's disease.
- Combined neuroprotective effects of celecoxib and memantine in experimental intracerebral hemorrhage.
- An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.