Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy.
- Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.
- Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B.
- Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis.
- The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid25-35 i.c.v.-injected mice: involvement of dopaminergic systems.
- Beta-blockers reduce the risk of early death in ischemic stroke.
- Early excitability changes in a novel acute model of transient focal ischemia and reperfusion in the in vitro isolated guinea pig brain.
- Identification of a pathogenic antibody response to native myelin oligodendrocyte glycoprotein in multiple sclerosis.
- CD5-CK2 binding/activation-deficient mice are resistant to experimental autoimmune encephalomyelitis: protection is associated with diminished populations of IL-17-expressing T cells in the central nervous system.
- A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase.
- Therapeutic targets and potential of the novel brain- permeable multifunctional iron chelator-monoamine oxidase inhibitor drug, M-30, for the treatment of Alzheimer's disease.
- Proteolytic processing of SDF-1alpha reveals a change in receptor specificity mediating HIV-associated neurodegeneration.
- Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1).
- Fluorinated conformationally restricted gamma-aminobutyric acid aminotransferase inhibitors.
- Novel heterobivalent tacrine derivatives as cholinesterase inhibitors with notable selectivity toward butyrylcholinesterase.
- Parecoxib is neuroprotective in spontaneously hypertensive rats after transient middle cerebral artery occlusion: a divided treatment response?
- Neuronal nitric oxide synthase plays a key role in CNS demyelination.
- Reduced severity of experimental autoimmune encephalomyelitis in GMF-deficient mice.
- trans-2,3-dihydroxy-6a,7,8,12b-tetrahydro-6H-chromeno[3,4-c]isoquinoline: synthesis, resolution, and preliminary pharmacological characterization of a new dopamine D1 receptor full agonist.
- Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo.
- 3D-QSAR design of novel antiepileptic sulfamides.
- Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
- Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.
- Cilostazol, a phosphodiesterase 3 inhibitor, protects mice against acute and late ischemic brain injuries.
- Effects of a novel tripeptide on neurological outcomes after spinal cord injury.
- Evaluation of N-desmethylclozapine as a potential antipsychotic--preclinical studies.
- Disease-modifying trials in Alzheimer's disease: a European task force consensus.
- Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.
- Overexpression of hippocampal Ca2+/calmodulin-dependent protein kinase II improves spatial memory.
- Platelet beta-secretase activity is increased in Alzheimer's disease.
- Long-term effects of antidepressants on cognition in patients with Alzheimer's disease.
- Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation.
- Amino acid-based enantiomerically pure 3-substituted 1,4-benzodiazepin-2-ones: a new class of anti-ischemic agents.
- A novel cell-permeable antioxidant peptide, SS31, attenuates ischemic brain injury by down-regulating CD36.
- Synthetic small molecule furin inhibitors derived from 2,5-dideoxystreptamine.
- Scaffold of the cyclooxygenase-2 (COX-2) inhibitor carprofen provides Alzheimer gamma-secretase modulators.
- New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.
- Novel multipotent tacrine-dihydropyridine hybrids with improved acetylcholinesterase inhibitory and neuroprotective activities as potential drugs for the treatment of Alzheimer's disease.
- N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors.
- PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis.
- Subcutaneous Nogo receptor removes brain amyloid-beta and improves spatial memory in Alzheimer's transgenic mice.
- Role of glutathione in neuroprotective effects of mood stabilizing drugs lithium and valproate.
- Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis.
- Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice.
- Effects of anti-VEGF antibody on blood-brain barrier disruption in focal cerebral ischemia.
- Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats.
- Development of new pyrrolopyrimidine-based inhibitors of Janus kinase 3 (JAK3).
- Simvastatin enhances learning and memory independent of amyloid load in mice.
- Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys.
- N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.