Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease.
- Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.
- Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not.
- 4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
- Protective effect of (4-methoxybenzylidene)-(3-methoxynophenyl)amine against neuronal cell death induced by oxygen and glucose deprivation in rat organotypic hippocampal slice culture.
- The nitric oxide donor LA 419 decreases ischemic brain damage.
- Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy.
- Epsilon PKC may contribute to the protective effect of hypothermia in a rat focal cerebral ischemia model.
- Systematic review and meta-analysis of the efficacy of tirilazad in experimental stroke.
- Synthetic biomimetic hydrogels incorporated with ephrin-A1 for therapeutic angiogenesis.
- Pharmacological induction of heat shock protein exerts neuroprotective effects in experimental intracerebral hemorrhage.
- SEPS1 protects RAW264.7 cells from pharmacological ER stress agent-induced apoptosis.
- Antidepressants increase glial cell line-derived neurotrophic factor production through monoamine-independent activation of protein tyrosine kinase and extracellular signal-regulated kinase in glial cells.
- Monoclonal antibody against T-cell receptor alphabeta induces self-tolerance in chronic experimental autoimmune encephalomyelitis.
- Therapeutic time window of post-ischemic mild hypothermia and the gene expression associated with the neuroprotection in rat focal cerebral ischemia.
- Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis.
- Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
- Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype.
- alpha7 Nicotinic receptor gene delivery into mouse hippocampal neurons leads to functional receptor expression, improved spatial memory-related performance, and tau hyperphosphorylation.
- Neuronal apoptotic signaling pathways probed and intervened by synthetically and modularly modified (SMM) chemokines.
- Nasal inoculation of an adenovirus vector encoding 11 tandem repeats of Abeta1-6 upregulates IL-10 expression and reduces amyloid load in a Mo/Hu APPswe PS1dE9 mouse model of Alzheimer's disease.
- Control of spasticity in a multiple sclerosis model is mediated by CB1, not CB2, cannabinoid receptors.
- Combination of IFN beta-1a (Avonex) and mycophenolate mofetil (Cellcept) in multiple sclerosis.
- Increase of cannabinoid CB1 receptor density in the hippocampus of streptozotocin-induced diabetic rats.
- Inhibition of Abeta production by NF-kappaB inhibitors.
- Neurotrophic modulation of myelinated cutaneous innervation and mechanical sensory loss in diabetic mice.
- A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35.
- Does fluoxetine have any effect on the cognition of patients with mild cognitive impairment? A double-blind, placebo-controlled, clinical trial.
- Effects of TC-1734 (AZD3480), a selective neuronal nicotinic receptor agonist, on cognitive performance and the EEG of young healthy male volunteers.
- The upregulation of glial glutamate transporter-1 participates in the induction of brain ischemic tolerance in rats.
- Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.
- Spatiotemporal control of vascular endothelial growth factor delivery from injectable hydrogels enhances angiogenesis.
- Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation.
- 3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists.
- Discovery of anticonvulsant activity of abietic acid through application of linear discriminant analysis.
- TNF-alpha knockout and minocycline treatment attenuates blood-brain barrier leakage in MPTP-treated mice.
- Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and -2 in ischemic brain injury.
- Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.
- Regulatory T cell vaccination without autoantigen protects against experimental autoimmune encephalomyelitis.
- Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression.
- The nitric oxide donor LA 419 decreases brain damage in a focal ischemia model.
- Selective L-nitroargininylaminopyrrolidine and L-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors.
- The CB2 cannabinoid agonist AM-1241 prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis when initiated at symptom onset.
- Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra.
- GISP: a novel brain-specific protein that promotes surface expression and function of GABA(B) receptors.
- Novel modulators of amyloid-beta precursor protein processing.
- Acyl peptide hydrolase, a serine proteinase isolated from conditioned medium of neuroblastoma cells, degrades the amyloid-beta peptide.
- Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease.
- Early disruptions of the blood-brain barrier may contribute to exacerbated neuronal damage and prolonged functional recovery following stroke in aged rats.
- A Phase 2 study of a purified, inactivated virus vaccine to prevent Japanese encephalitis.