Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Synthesis and SAR studies of a novel class of S1P1 receptor antagonists.
- A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease--rivastigmine patch versus capsule.
- Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation.
- Neuroprotective effect of taurine against focal cerebral ischemia in rats possibly mediated by activation of both GABAA and glycine receptors.
- Neuroprotective efficacy of FR901459, a novel derivative of cyclosporin A, in in vitro mitochondrial damage and in vivo transient cerebral ischemia models.
- Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers.
- Region-specific overexpression of P-glycoprotein at the blood-brain barrier affects brain uptake of phenytoin in epileptic rats.
- Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists.
- Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
- Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production.
- Ameliorative effects of a neuroprotective agent, T-817MA, on place learning deficits induced by continuous infusion of amyloid-beta peptide (1-40) in rats.
- Neuroprotective effects of the novel polyethylene glycol-hemoglobin conjugate SB1 on experimental cerebral thromboembolism in rats.
- Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation.
- Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation.
- 2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.
- Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells.
- Ropinirole 24-hour prolonged release: randomized, controlled study in advanced Parkinson disease.
- Dissociation of experimental allergic encephalomyelitis protective effect and allergic side reactions in tolerization with neuroantigen.
- MHP-133, a drug with multiple CNS targets: potential for neuroprotection and enhanced cognition.
- Minocycline attenuates neuronal cell death and improves cognitive impairment in Alzheimer's disease models.
- Neuroprotective effect of L-kynurenine sulfate administered before focal cerebral ischemia in mice and global cerebral ischemia in gerbils.
- A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke.
- Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with beta-amyloid in rats.
- Effects of statins on alpha7 nicotinic receptor, cholinesterase and alpha-form of secreted amyloid precursor peptide in SH-SY5Y cells.
- The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.
- Wide spectrum modulation by KP-544 in models relevant for neuronal survival.
- Testosterone derivatives are neuroprotective agents in experimental diabetic neuropathy.
- Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors.
- Pharmacodynamics of interferon beta in multiple sclerosis patients with or without serum neutralizing antibodies.
- Structure-based design and synthesis of Nomega-nitro-L-arginine-containing peptidomimetics as selective inhibitors of neuronal nitric oxide synthase. Displacement of the heme structural water.
- Effect of immunomodulation with human interferon-beta on early functional recovery from experimental spinal cord injury.
- Infarct volume after transient middle cerebral artery occlusion (MCAo) can be reduced by attenuation but not by inactivation of c-Jun action.
- Edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a radical scavenger, prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in the substantia nigra but not the striatum.
- The role of the Na(+)/Ca(2+) exchanger (NCX) in neurons following ischaemia.
- Risk of myocardial infarction or vascular death after first ischemic stroke: the Northern Manhattan Study.
- Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
- Poly(ADP-ribose) polymerase inhibition by cilostazol is implicated in the neuroprotective effect against focal cerebral ischemic infarct in rat.
- Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human beta-secretase (BACE1).
- Potent and selective isophthalamide S(2) hydroxyethylamine inhibitors of BACE1.
- p150/95 (CD11c/CD18) Expression Is Required for the Development of Experimental Autoimmune Encephalomyelitis.
- Evaluation of erythropoietin effects on cerebral ischemia in rats.
- Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons.
- A cell-based model of alpha-synucleinopathy for screening compounds with therapeutic potential of Parkinson's disease.
- Fampridine-SR in multiple sclerosis: a randomized, double-blind, placebo-controlled, dose-ranging study.
- Highly active antiretroviral therapy of cognitive dysfunction and neuronal abnormalities in SCID mice with HIV encephalitis.
- COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.
- Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells.
- Striatal delivery of CERE-120, an AAV2 vector encoding human neurturin, enhances activity of the dopaminergic nigrostriatal system in aged monkeys.
- Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo.
- METABOLISM AND DISPOSITION OF A SELECTIVE {alpha}7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST IN HUMANS.