Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1.
- Involvement of the potassium-dependent sodium/calcium exchanger gene product NCKX2 in the brain insult induced by permanent focal cerebral ischemia.
- New diphenylacetylenes as probes for positron emission tomographic imaging of amyloid plaques.
- G-CSF enhances stem cell proliferation in rat hippocampus after transient middle cerebral artery occlusion.
- A tetrazolyl-substituted subtype-selective AMPA receptor agonist.
- Potentiation of neurogenesis and angiogenesis by G-CSF after focal cerebral ischemia in rats.
- Neprilysin protects neurons against Abeta peptide toxicity.
- Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors.
- Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a community-based cohort.
- Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial.
- Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
- Complete Spinal Cord Injury Treatment using Autologous Bone Marrow Cell Transplantation and Bone Marrow Stimulation with Granulocyte Macrophage-Colony Stimulating Factor (GM-CSF): Phase I/II Clinical Trial.
- Biogenesis and processing of the amyloid precursor protein in the early secretory pathway.
- Subsequent exposure to the choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons in rats.
- Neuroprotection by small molecule activators of the NGF receptor.
- Neuroprotection with Erythropoietin Administration Following Controlled Cortical Impact Injury in Rats.
- Acute vs chronic effects of l-dopa on bladder function in patients with mild Parkinson disease.
- Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity.
- Nootropic alpha7 nicotinic receptor allosteric modulator derived from GABAA receptor modulators.
- Identifying Druglike Inhibitors of Myelin-Reactive T Cells by Phenotypic High-Throughput Screening of a Small-Molecule Library.
- High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation.
- Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors.
- Long-term follow-up of patients treated with glatiramer acetate: a multicentre, multinational extension of the European/Canadian double-blind, placebo-controlled, MRI-monitored trial.
- Paclitaxel C-10 carbamates: Potential candidates for the treatment of neurodegenerative tauopathies.
- Minocycline, a second-generation tetracycline, as a neuroprotective agent in an animal model of schizophrenia.
- Modulation of experimental autoimmune encephalomyelitis by VLA-2 blockade.
- The consequences of reducing expression of the alpha7 nicotinic receptor by RNA interference and of stimulating its activity with an alpha7 agonist in SH-SY5Y cells indicate that this receptor plays a neuroprotective role in connection with the pathogenesis of Alzheimer's disease.
- Contribution of downregulation of L-type calcium currents to delayed neuronal death in rat hippocampus after global cerebral ischemia and reperfusion.
- The Effect of Recombinant Human EPO on Neurovasculature Repair after Focal Ischemic Stroke in Neonatal Rats.
- Amyloid-beta reduction by memapsin 2 (beta-secretase) immunization.
- Identification and characterization of TRO19622 (cholest-4-en-3-one, oxime), a novel drug candidate for amyotrophic lateral sclerosis.
- Memantine in Moderate to Severe Alzheimer's Disease: a Meta-Analysis of Randomised Clinical Trials.
- Calorie restriction ameliorates neurodegenerative phenotypes in forebrain-specific presenilin-1 and presenilin-2 double knockout mice.
- Efficacy and safety of antidepressants for treatment of depression in Alzheimer's disease: a metaanalysis.
- Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): A gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.
- Design and synthesis of benzoazepinone-derived cyclic malonamides and aminoamides as potent gamma-secretase inhibitors.
- Testosterone treatment in multiple sclerosis: a pilot study.
- EXACT: rivastigmine improves the high prevalence of attention deficits and mood and behaviour symptoms in Alzheimer's disease.
- Pharmacokinetics and Amyloid Plaque Targeting Ability of a Novel Peptide-Based Magnetic Resonance Contrast Agent in Wild Type and Alzheimer's Disease Transgenic Mice.
- Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins.
- Minocycline inhibits 5-lipoxygenase activation and brain inflammation after focal cerebral ischemia in rats.
- A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation.
- Endothelin(A) receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils.
- Identification and SAR of potent and selective non-peptide obeline somatostatin sst(1) receptor antagonists.
- Synthesis of sialic acid derivatives as ligands for the myelin-associated glycoprotein (MAG).
- Neuroprotective effects of 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid (Trolox), an antioxidant in middle cerebral artery occlusion induced focal cerebral ischemia in rats.
- Do sodium channel blockers have neuroprotective effect after onset of ischemic insult?
- Neuroprotective effect of dapsone in patients with acute ischemic stroke: a pilot study.
- Desipramine activated bcl-2 expression and inhibited lipopolysaccharide-induced apoptosis in hippocampus-derived adult neural stem cells.
- Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia.