Sitemap > Breaking Research > Neurodegenerative & Neuroelectrophysiological Disorders
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- Liposomal vaccines with conformation-specific amyloid peptide antigens define immune response and efficacy in APP transgenic mice.
- G-CSF rescues the memory impairment of animal models of Alzheimer's disease.
- Cost-effectiveness of memantine in moderate-to-severe Alzheimer's disease patients receiving donepezil.
- Neuroprotective effects of alpha(2)-adrenergic receptor agonists.
- Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.
- NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.
- Antigen-specific suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor.
- Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation.
- Pharmacokinetics and Pharmacodynamics of the Novel Daily Rivastigmine Transdermal Patch Compared With Twice-daily Capsules in Alzheimer's Disease Patients.
- Disposition and metabolism of (2S,3S,4R)-N''-cyano-N-(6-amino-3,4-dihydro-3-hydroxy-2-methyl-2-dimethoxy methyl-2H-benzopyran-4-yl)-N'-benzylguanidine, a novel neuroprotective agent for ischemia-reperfusion damage, in rats.
- p150/95 (CD11c/CD18) Expression Is Required for the Development of Experimental Autoimmune Encephalomyelitis.
- Cardioprotective effects of Nitric Oxide-Aspirin in myocardial ischemia-reperfused rats.
- Galantamine post-ischemia provides neuroprotection and memory recovery against transient global cerebral ischemia in gerbils.
- Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity.
- Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.
- Comparative neuroprotective effect of sodium channel blockers after experimental spinal cord injury.
- AAV2-mediated delivery of human neurturin to the rat nigrostriatal system: Long-term efficacy and tolerability of CERE-120 for Parkinson's disease.
- Long-term effects of rivastigmine treatment on the need for psychotropic medications in nursing home patients with Alzheimer's disease : results of a 52-week open-label study.
- Novel Ergopeptides as Dual Ligands for Adenosine and Dopamine Receptors.
- Functional Differences in Epigenetic Modulators-Superiority of Mercaptoacetamide-Based Histone Deacetylase Inhibitors Relative to Hydroxamates in Cortical Neuron Neuroprotection Studies.
- Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
- Discovery of Novel 2-Anilinopyrazolo[1,5-a]pyrimidine Derivatives as c-Src Kinase Inhibitors for the Treatment of Acute Ischemic Stroke.
- Neutralizing antibodies to interferon beta-1b are not associated with disease worsening in multiple sclerosis.
- Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein.
- A 24-week randomized, controlled trial of memantine in patients with moderate-to-severe Alzheimer disease.
- Glatiramer acetate could be a potential therapeutic agent for Parkinson's disease through its neuroprotective and anti-inflammatory effects.
- Central histamine H3 receptor signaling negatively regulates susceptibility to autoimmune inflammatory disease of the CNS.
- Design, Synthesis, and Pharmacology of Novel 7-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of AMPA Receptors.
- PP2, a potent inhibitor of Src family kinases, protects against hippocampal CA1 pyramidal cell death after transient global brain ischemia.
- The CB1 cannabinoid receptor mediates excitotoxicity-induced neural progenitor proliferation and neurogenesis.
- Polyunsaturated Fatty Acids Are Cerebral Vasodilators via the TREK-1 Potassium Channel.
- Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice.
- Olanzapine potentiates neuronal survival and neural stem cell differentiation: regulation of endoplasmic reticulum stress response proteins.
- Effect of NXY-059, a novel neuroprotectant, on the pharmacokinetics of a single dose of digoxin in healthy subjects.
- Estrogen has anti-amyloidogenic effects on Alzheimer's beta-amyloid fibrils in vitro.
- Cannabinoid receptor stimulation is anti-inflammatory and improves memory in old rats.
- Design, synthesis, binding, and molecular modeling studies of new potent ligands of cannabinoid receptors.
- Molecular modeling of histamine H3 receptor and QSAR studies on arylbenzofuran derived H3 antagonists.
- Distinct profiles of {alpha}7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes.
- Neuroprotective Effect of PKC{delta} Inhibitor Rottlerin in Cell Culture and Animal Models of Parkinson's Disease.
- Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists.
- Inhibiting epidermal growth factor receptor improves structural, locomotor, sensory, and bladder recovery from experimental spinal cord injury.
- Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury.
- Safety and Tolerability of NXY-059 for Acute Intracerebral Hemorrhage. The CHANT Trial.
- PGD(2) DP1 receptor protects brain from ischemia-reperfusion injury.
- Abeta(42) gene vaccine prevents Abeta(42) deposition in brain of double transgenic mice.
- Synthesis and cannabinoid activity of 1-substituted-indole-3-oxadiazole derivatives: Novel agonists for the CB(1) receptor.
- Discovery of Isonicotinamide Derived beta-Secretase Inhibitors: In Vivo Reduction of beta-Amyloid.
- Squalestatin protects neurons and reduces the activation of cytoplasmic phospholipase A(2) by Abeta(1-42).
- Protein kinase C dependent inhibition of the heteromeric Kir4.1-Kir5.1 channel.