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- Randomized, double-blind, multicenter trial comparing two doses of arzoxifene (LY353381) in hormone-sensitive advanced or metastatic breast cancer patients.
- Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
- Inhibitor of p42/44 mitogen-activated protein kinase, but not p38 MAPK, attenuated antigen challenge of guinea pig airways in vitro.
- Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors.
- Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH2)3CO-His-D-Phe-Arg-Trp-NH2]. An additional binding site within the human melanocortin receptor 1?
- Aptamer selection for the inhibition of cell adhesion with fibronectin as target.
- Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies.
- Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer.
- Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial.
- Excess risk of cancer in patients with primary venous thromboembolism: a national, population-based cohort study.
- Vardenafil (Levitra) for erectile dysfunction: a systematic review and meta-analysis of clinical trial reports.
- Inhibition of papilloma progression by antisense oligonucleotides targeted to HPV11 E6/E7 RNA.
- Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
- Antineoplastic effects of peroxisome proliferator-activated receptor gamma agonists.
- Differences in gene expression between B-cell chronic lymphocytic leukemia and normal B cells: a meta-analysis of three microarray studies.
- Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt.
- BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo.
- Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase.
- Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer.
- Specifically activated memory T cell subsets from cancer patients recognize and reject xenotransplanted autologous tumors.
- Adenovirus-mediated transfer of siRNA against survivin induced apoptosis and attenuated tumor cell growth in vitro and in vivo.
- Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice.
- Noninvasive delivery of small inhibitory RNA and other reagents to pulmonary alveoli in mice.
- A pilot study of antiangiogenic therapy with bevacizumab and thalidomide in patients with metastatic renal cell carcinoma.
- Jak kinase activity is required for lymphoma invasion and metastasis.
- SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.
- Targeting autocrine and paracrine VEGF receptor pathways inhibits human lymphoma xenografts in vivo.
- Multistep process through which adenoviral vector vaccine overcomes anergy to tumor-associated antigens.
- Combretastatin family member OXI4503 induces tumor vascular collapse through the induction of endothelial apoptosis.
- N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2.
- Synthesis and antitumor activity of quinonoid derivatives of cannabinoids.
- Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.
- Synthesis and biological evaluation of a new class of geldanamycin derivatives as potent inhibitors of Hsp90.
- Prevalence of irritable bowel syndrome: a community survey.
- The A3 adenosine receptor is highly expressed in tumor versus normal cells: potential target for tumor growth inhibition.
- Angiogenesis inhibition by an oncolytic herpes virus expressing interleukin 12.
- Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.
- Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model.
- Antisense protein kinase A RIalpha inhibits 7,12-dimethylbenz(a)anthracene-induction of mammary cancer: blockade at the initial phase of carcinogenesis.
- Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody.
- Single-blind, randomized controlled study of the clinical and urodynamic effects of an alpha-blocker (naftopidil) and phytotherapy (eviprostat) in the treatment of benign prostatic hyperplasia.
- Possible (enzymatic) routes and biological sites for metabolic reduction of BNP7787, a new protector against cisplatin-induced side-effects.
- Is interleukin-13 critical in maintaining airway hyperresponsiveness in allergen-challenged mice?
- Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration.
- Comparison of selective retinoic acid receptor- and retinoic X receptor-mediated efficacy, tolerance, and survival in cutaneous t-cell lymphoma.
- Thalidomide for patients with relapsed multiple myeloma after high-dose chemotherapy and stem cell transplantation: results of an open-label multicenter phase 2 study of efficacy, toxicity, and biological activity.
- Antitumor effect of MCC-465, pegylated liposomal doxorubicin tagged with newly developed monoclonal antibody GAH, in colorectal cancer xenografts.
- Phase II study of trastuzumab plus gemcitabine in chemotherapy-pretreated patients with metastatic breast cancer.
- A QSAR study on inhibitory activities of 1-phenylbenzimidazoles against the platelet-derived growth factor receptor.
- Effect of oral CCK-1 agonist GI181771X on fasting and postprandial gastric functions in healthy volunteers.
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