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- Adenoviral gene transfer of FGF-5 to hibernating myocardium improves function and stimulates myocytes to hypertrophy and reenter the cell cycle.
- Application of small interfering RNA (siRNA) for modulation of airway epithelial gene expression.
- High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID).
- Nonionic amphiphilic block copolymers promote gene transfer to the lung.
- High doses of siRNAs induce eri-1 and adar-1 gene expression and reduce the efficiency of RNA interference in the mouse.
- The specific delivery of proteins to human liver cells by engineered bio-nanocapsules.
- Serum albumin enhances polyethylenimine-mediated gene delivery to human respiratory epithelial cells.
- PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice.
- A peptide carrier with a built-in vaccine adjuvant: construction of immunogenic conjugates.
- The proteasome metabolizes peptide-mediated nonviral gene delivery systems.
- Exploration of peptide motifs for potent non-viral gene delivery highly selective for dividing cells.
- A novel insulin delivery algorithm in rats with type 1 diabetes: the fading memory proportional-derivative method.
- Peptide nucleic acid antisense oligomer as a therapeutic strategy against bacterial infection: proof of principle using mouse intraperitoneal infection.
- A new direction for gene therapy: intrathymic T cell-specific lentiviral gene transfer.
- Specific pharmacological dimerization of KDR in lentivirally transduced human hematopoietic cells activates anti-apoptotic and proliferative mechanisms.
- A rapid computational filter for cytochrome P450 1A2 inhibition potential of compound libraries.
- Intracellular trafficking of nonviral vectors.
- A high-density screen for linkage in multiple sclerosis.
- Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.
- A collagen IV matrix is required for guinea pig gastric epithelial cell monolayers to provide an optimal model of the stomach surface for biopharmaceutical screening.
- Targeted delivery of therapeutic oligonucleotides to pulmonary circulation.
- Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis.
- Novel detection system for biomolecules using nano-sized bacterial magnetic particles and magnetic force microscopy.
- Cationic liposomes containing mycobacterial lipids: a new powerful Th1 adjuvant system.
- Granulocyte-colony stimulating factor augments neovascularization induced by bone marrow transplantation in rat hindlimb ischemia.
- Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model.
- A network-based analysis of systemic inflammation in humans.
- The transcriptional landscape of the mammalian genome.
- Antisense transcription in the mammalian transcriptome.
- Elucidation of the small RNA component of the transcriptome.
- A strategy for probing the function of noncoding RNAs finds a repressor of NFAT.
- Comparing antigenicity and immunogenicity of engineered gp120.
- Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain.
- Toward high-resolution de novo structure prediction for small proteins.
- Tumor-targeted, systemic delivery of therapeutic viral vectors using hitchhiking on antigen-specific T cells.
- Enhancement of innate and cell-mediated immunity by antimycobacterial antibodies.
- Coronaviruses as vectors: stability of foreign gene expression.
- Novel, single-dose microsphere formulation of azithromycin versus 7-day levofloxacin therapy for treatment of mild to moderate community-acquired Pneumonia in adults.
- Inhibition of coreceptor-independent cell-to-cell human immunodeficiency virus type 1 transmission by a CD4-immunoglobulin G2 fusion protein.
- Oral therapy using nanoparticle-encapsulated antituberculosis drugs in guinea pigs infected with Mycobacterium tuberculosis.
- Towards a proteome-scale map of the human protein-protein interaction network.
- Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence.
- Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia.
- Application of high amplitude alternating magnetic fields for heat induction of nanoparticles localized in cancer.
- Targeted virus replication plus immunotherapy eradicates primary and distant pancreatic tumors in nude mice.
- Prediction of regulatory modules comprising microRNAs and target genes.
- An attempt to define allergen-specific molecular surface features: a bioinformatic approach.
- A novel bispecific protein (ULBP2-BB4) targeting the NKG2D receptor on natural killer (NK) cells and CD138 activates NK cells and has potent antitumor activity against human multiple myeloma in vitro and in vivo.
- Generation and characterization of novel stromal specific antibodies.
- Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells.
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